Reversibility of brain glucose kinetics in type 2 diabetic subjects
2 型糖尿病受试者脑葡萄糖动力学的可逆性
基本信息
- 批准号:10664102
- 负责人:
- 金额:$ 19.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-15 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAcuteAgeAnimalsAreaBlood - brain barrier anatomyBrainBrain regionCentral Nervous SystemCerebrumChronicCitric Acid CycleClosure by clampConsumptionDataDeuteriumDiabetes MellitusDown-RegulationEnergy MetabolismEnergy-Generating ResourcesExposure toFeasibility StudiesFundingFutureGlucoseGlucose ClampGlucose TransporterGlutamatesGlutamineGlycosylated hemoglobin AGoalsHumanHyperglycemiaImageImpaired cognitionIndividualInterventionIntravenous infusion proceduresKineticsLabelLightMagnetic Resonance SpectroscopyMapsMeasurementMeasuresMentorsMetabolicMethodological StudiesMethodologyMethodsMorbidity - disease rateNMR SpectroscopyNerve DegenerationNeuronsNon-Insulin-Dependent Diabetes MellitusOccipital lobeParticipantPatientsPeripheralPhysiologicalPilot ProjectsPlasmaPlayPrefrontal CortexPrevalenceProtonsReportingSLC2A1 geneSample SizeTechniquesTestingTrainingType 2 diabeticblood glucose regulationbrain dysfunctioncell injurycognitive changedesigndiabetes mellitus therapyexperienceglucose metabolismglucose transportglycemic controlgray matterhealthy weightimprovedmagnetic resonance spectroscopic imagingmetabolic abnormality assessmentmetabolic imagingmortalitynon-diabeticnovelpost interventionpreventresponse
项目摘要
Project summary/abstract
The prevalence of type 2 diabetes mellitus continues to rise worldwide and despite different treatment
options, many patients fail to achieve glycemic target, which leads to increased morbidity and mortality.
Chronic exposure to hyperglycemia has been shown in both animal and human studies to decrease glucose
transport into the brain, presumably through down-regulation of GLUT1 at the blood brain barrier, which has
been postulated to be a protective adaptation of the central nervous system against the harmful consequences
of hyperglycemia. However, GLUT1 down regulation may lead to reduced brain glucose metabolism leading to
neuronal damage, neurodegeneration and cognitive decline. Whether these changes in cerebral glucose
transport seen in patients with poorly controlled diabetes can be reversed is unknown. The main goal of this
study is to determine whether improvement of glucose control in poorly controlled T2DM patient will restore
brain glucose transport kinetics and rigorously assess which factors (i.e. duration DM and glycemic control)
contribute to the observed improvements by using classic metabolic studies as well as state-of-the-art brain
nuclear magnetic resonance spectroscopy (MRS) techniques. The findings obtained from this study will help
elucidate if intensive diabetes therapy may be associated with reduced brain dysfunction from hyperglycemia.
项目总结/文摘
项目成果
期刊论文数量(0)
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