Integration of social and nonsocial information in the primate brain

灵长类大脑中社交和非社交信息的整合

• 批准号: 10664869
• 负责人: Joseph Simon
• 金额: $ 4.87万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10664869
• 关键词: Advanced Development; Anatomy; Anterior; Area; Behavior; Brain; Brain Mapping; Brain region; Characteristics; Clinical; Code; Cognitive; Complex; Computer Analysis; Computer Models; Cues; Data; Decision Making; Diagnostic and Statistical Manual of Mental Disorders; Disease; Dissociation; Distress; Educational process of instructing; Emotions; Environment; Epilepsy; Equation; Exhibits; Eye; Eye Movements; Face; Fellowship; Foundations; Future; Goals; Human; Impaired cognition; Impairment; Juice; Knowledge; Label; Learning; Location; Macaca mulatta; Medial; Mental Depression; Mental Health; Mental disorders; Methods; Modeling; Monkeys; Motor; Nature; Neuroanatomy; Neurobiology; Neurons; Neurophysiology - biologic function; Neurosciences; Pathologic; Patients; Phase; Postdoctoral Fellow; Primates; Process; Research; Research Personnel; Rewards; Rodent; Saccades; Schizophrenia; Signal Transduction; Site; Social Behavior; Social Environment; Social Functioning; Social Interaction; Social status; Stimulus; Study Subject; Study models; Testing; Therapeutic; Tissues; Training; Visual; Visual Perception; Work; autism spectrum disorder; career; cingulate gyrus; cognitive control; design; frontal eye fields; frontal lobe; gaze; human subject; improved; insight; mental health related disorder; multimodality; neural; neural circuit; neuromechanism; neuronal circuitry; neurophysiology; next generation; nonhuman primate; novel; novel strategies; response; social; social cognition; social engagement; social group; social neuroscience; tool

Project Summary Primate species frequently use social information to inform their decisions, for instance, to help make inferences about potential threats or rewards in the environment. The Diagnostics and Statistical Manual for Mental Disorders (DSM) has labeled social impairments, including social cognition, as a primary characteristic of many mental health-related disorders, including Autism Spectrum Disorder and Schizophrenia. Therefore, understanding the neurobiology surrounding social cognition and decision-making is of critical importance. Work in this field has primarily centered around human and rodent studies, mapping brain regions related to social cognition and innate social functions. To understand the neural mechanisms governing complex social reasoning, however, we must investigate neural circuit function in primate brains. Neurophysiology recording in monkeys, particularly rhesus macaque, provide us with an ideal model to investigate these questions. Rhesus monkeys are a social species with similar neuroanatomy to humans and engage in complex social behaviors. Thus, they can provide valuable insight to the mechanisms of social cognition in the brain. The long-term goal of this project is to determine whether the brain encodes social information in multimodal circuits, or if social information is encoded in a fundamentally unique way. In the following proposal, I detail how monkeys are an ideal model to study social cognition using a neurophysiological approach. In Aim 1, I have taught monkeys to use social and nonsocial visual guides to select correct target locations for a juice-reward. In the F99-phase, I will record and analysis neurons from the anterior cingulate gyrus (ACCg) and the frontal eye field (FEF), interconnected regions implicated in social cognition and motor planning, to determine how this circuit encodes goal-directed information derived from social and nonsocial cues. In Aim 2, under the K00 phase, I discuss my proposal for a multi-subject study incorporating neurophysiological recording and computational modeling and analysis to understand how neural activity facilitates social interactive behavior. Overall, my goal for this fellowship is to provide myself with the tools, knowledge, and ability to successfully make a lasting impact on the neuroscience field and improve our knowledge of how social cognition impacts our mental health.

项目摘要 灵长类物种经常使用社会信息来为它们的决定提供信息，例如，帮助进行推理 关于环境中的潜在威胁或回报。心理诊断与统计手册 障碍(DSM)将包括社会认知在内的社会障碍列为许多疾病的主要特征 与精神健康相关的障碍，包括自闭症谱系障碍和精神分裂症。因此， 了解围绕社会认知和决策的神经生物学是至关重要的。工作 这一领域的研究主要集中在人类和啮齿动物的研究上，绘制出与社会相关的大脑区域 认知和先天的社会功能。了解支配复杂社会的神经机制 然而，推理时，我们必须研究灵长类动物大脑中的神经回路功能。神经生理学记录 猴子，尤其是恒河猴，为我们提供了一个研究这些问题的理想模型。恒河猴 猴子是一种社会性物种，具有与人类相似的神经解剖结构，并从事复杂的社会行为。 因此，它们可以为大脑中的社会认知机制提供有价值的见解。长期目标 这个项目的目的是确定大脑是否在多模式回路中编码社交信息，或者是否 信息以一种从根本上独特的方式编码。在下面的提案中，我详细介绍了猴子是如何 使用神经生理学方法研究社会认知的理想模型。在《目标1》中，我教猴子 使用社交和非社交视觉指南来选择正确的目标位置，以获得果汁奖励。在F99阶段，我 将记录和分析来自前扣带回(ACCG)和额叶眼场(FEF)的神经元， 与社会认知和运动规划有关的相互关联的区域，以确定该回路如何编码 从社会和非社会线索中获得的目标导向的信息。在目标2中，在K00阶段，我讨论了我的 建议进行一项结合神经生理学记录和计算建模的多学科研究 分析以了解神经活动如何促进社会互动行为。总体而言，我的目标是 团契是为自己提供工具、知识和能力，以成功地对 并提高我们对社会认知如何影响我们的心理健康的认识。