Integration of social and nonsocial information in the primate brain

灵长类大脑中社交和非社交信息的整合

• 批准号: 10664869
• 负责人: Joseph Simon
• 金额: $ 4.87万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10664869
• 关键词: Advanced Development; Anatomy; Anterior; Area; Behavior; Brain; Brain Mapping; Brain region; Characteristics; Clinical; Code; Cognitive; Complex; Computer Analysis; Computer Models; Cues; Data; Decision Making; Diagnostic and Statistical Manual of Mental Disorders; Disease; Dissociation; Distress; Educational process of instructing; Emotions; Environment; Epilepsy; Equation; Exhibits; Eye; Eye Movements; Face; Fellowship; Foundations; Future; Goals; Human; Impaired cognition; Impairment; Juice; Knowledge; Label; Learning; Location; Macaca mulatta; Medial; Mental Depression; Mental Health; Mental disorders; Methods; Modeling; Monkeys; Motor; Nature; Neuroanatomy; Neurobiology; Neurons; Neurophysiology - biologic function; Neurosciences; Pathologic; Patients; Phase; Postdoctoral Fellow; Primates; Process; Research; Research Personnel; Rewards; Rodent; Saccades; Schizophrenia; Signal Transduction; Site; Social Behavior; Social Environment; Social Functioning; Social Interaction; Social status; Stimulus; Study Subject; Study models; Testing; Therapeutic; Tissues; Training; Visual; Visual Perception; Work; autism spectrum disorder; career; cingulate gyrus; cognitive control; design; frontal eye fields; frontal lobe; gaze; human subject; improved; insight; mental health related disorder; multimodality; neural; neural circuit; neuromechanism; neuronal circuitry; neurophysiology; next generation; nonhuman primate; novel; novel strategies; response; social; social cognition; social engagement; social group; social neuroscience; tool

Project Summary Primate species frequently use social information to inform their decisions, for instance, to help make inferences about potential threats or rewards in the environment. The Diagnostics and Statistical Manual for Mental Disorders (DSM) has labeled social impairments, including social cognition, as a primary characteristic of many mental health-related disorders, including Autism Spectrum Disorder and Schizophrenia. Therefore, understanding the neurobiology surrounding social cognition and decision-making is of critical importance. Work in this field has primarily centered around human and rodent studies, mapping brain regions related to social cognition and innate social functions. To understand the neural mechanisms governing complex social reasoning, however, we must investigate neural circuit function in primate brains. Neurophysiology recording in monkeys, particularly rhesus macaque, provide us with an ideal model to investigate these questions. Rhesus monkeys are a social species with similar neuroanatomy to humans and engage in complex social behaviors. Thus, they can provide valuable insight to the mechanisms of social cognition in the brain. The long-term goal of this project is to determine whether the brain encodes social information in multimodal circuits, or if social information is encoded in a fundamentally unique way. In the following proposal, I detail how monkeys are an ideal model to study social cognition using a neurophysiological approach. In Aim 1, I have taught monkeys to use social and nonsocial visual guides to select correct target locations for a juice-reward. In the F99-phase, I will record and analysis neurons from the anterior cingulate gyrus (ACCg) and the frontal eye field (FEF), interconnected regions implicated in social cognition and motor planning, to determine how this circuit encodes goal-directed information derived from social and nonsocial cues. In Aim 2, under the K00 phase, I discuss my proposal for a multi-subject study incorporating neurophysiological recording and computational modeling and analysis to understand how neural activity facilitates social interactive behavior. Overall, my goal for this fellowship is to provide myself with the tools, knowledge, and ability to successfully make a lasting impact on the neuroscience field and improve our knowledge of how social cognition impacts our mental health.

项目摘要 灵长类动物经常使用社会信息来告知他们的决定，例如，帮助做出推断 环境中潜在的威胁或回报。精神疾病诊断与统计手册 DSM将包括社会认知在内的社会障碍标记为许多疾病的主要特征， 精神健康相关疾病，包括自闭症谱系障碍和精神分裂症。因此，我们认为， 理解围绕社会认知和决策的神经生物学至关重要。工作 在这一领域主要集中在人类和啮齿动物的研究，映射与社会相关的大脑区域， 认知和天生的社会功能。为了了解控制复杂社会行为的神经机制， 然而，我们必须研究灵长类动物大脑中的神经回路功能。神经生理学记录 猴子，特别是恒河猴，为我们研究这些问题提供了理想的模型。恒河 猴子是一种社会性物种，具有与人类相似的神经解剖学，并参与复杂的社会行为。 因此，它们可以为大脑中的社会认知机制提供有价值的见解。远景目标 这个项目的目的是确定大脑是否在多模态电路中编码社会信息，或者是否社会信息是由大脑编码的。 信息是以一种基本上独特的方式编码的。在下面的建议中，我详细介绍了猴子是如何成为一个 这是一个用神经生理学方法研究社会认知的理想模型。在目标1中，我教猴子 使用社交和非社交视觉指南来选择正确的目标位置，以获得果汁奖励。在F99阶段，我 将记录和分析前扣带回（ACCg）和额叶眼区（FEF）的神经元， 涉及社会认知和运动规划的相互连接的区域，以确定该回路如何编码 来自社会和非社会线索的目标导向信息。在目标2中，在K00阶段，我讨论了我的 建议进行多学科研究，包括神经生理学记录和计算建模， 分析以了解神经活动如何促进社交互动行为。总的来说，我的目标是 奖学金是为自己提供工具、知识和能力，以成功地对社会产生持久的影响 神经科学领域，并提高我们对社会认知如何影响我们的心理健康的知识。