From RRID to Resource Watch: A Knowledgebase of Biomedical Research Resources

从 RRID 到资源观察：生物医学研究资源知识库

• 批准号: 10664832
• 负责人: Anita ELZBIETA Bandrowski
• 金额: $ 55.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10664832
• 关键词: Antibodies; Biomedical Research; Cell Line; Collaborations; Communication; Communities; Computer software; Core Facility; Data; Databases; Decision Making; Ensure; Funding; Goals; Growth; Harvest; Individual; Information Networks; Infrastructure; Journals; Literature; Measurable; National Institute of Diabetes and Digestive and Kidney Diseases; Neurosciences; Nonprofit Organizations; Organism; Paper; Plasmids; Process; Reagent; Registries; Reproducibility; Research; Research Personnel; Research Project Summaries; Research Support; Resources; Role; Science; Scientist; Source; Specific qualifier value; Specificity; Structure; Time; United States National Institutes of Health; Universities; Validation; Writing; biomedical scientist; central database; digital; improved; indexing; information framework; information gathering; knowledge base; knowledge curation; knowledge integration; knowledgebase; model organisms databases; outreach; text searching; tool; web portal

Project Summary Research Resource Identifiers, RRIDs, are persistent identifiers for key research resources such as antibodies, cell lines, organisms and digital assets. They are in use in over 1300 biomedical journals and are supplied by authors to uniquely identify which resources are used within a study. The RRID project was launched as a grass- roots effort in 2014 to improve the identifiability of research resources in the biomedical literature. RRIDs depend on the collaboration of journals with comprehensive registries and stock centers, which provide an authoritative identifier for each resource type. The introduction of RRIDs has had a significant impact on our ability to identify and track the use of research resources in the biomedical literature. Papers that use RRIDs have improved identifiability of resources from <50% to >90%. RRIDs make it easier to track usage, assign credit, and aggregate information about how resources perform in the literature. Towards that end, we have assembled a curated knowledge base that provides information on RRID use in the literature. Because RRIDs are served from a central database which is used broadly by scientists as they write their papers, the portal can also serve as a central hub for disseminating critical information about how such reagents perform. For example, the RRID portal provides warnings on contaminated cell lines provided by Cellosaurus. However, such information on other types of resources is much more dispersed. Therefore, we built a related knowledge base, Resource Watch, that enhances the information about RRIDs. The RRID project has been bootstrapped on top of existing NIH-funded projects, but given its growth and importance to biomedicine, we seek to unify the current RRID project into a self-supporting entity.

项目摘要 研究资源标识符，RRID，是关键研究资源的永久标识符，例如抗体， 细胞系、生物体和数字资产。它们在1300多种生物医学期刊上使用，并由 作者唯一地确定研究中使用了哪些资源。RRID项目是作为草本植物启动的- Roots在2014年努力提高生物医学文献中研究资源的可识别性。RRID取决于 关于期刊与综合注册处和库存中心的合作，它们提供了一个权威的 每种资源类型的标识符。RRID的引入对我们识别 并跟踪生物医学文献中研究资源的使用情况。使用RRID的论文有所改进 资源的可识别率从&lt；50%到&gt；90%。RRID使跟踪使用情况、分配信用和聚合变得更容易 有关文献中资源执行情况的信息。为此，我们召集了一个策划人 提供有关文献中RRID使用的信息的知识库。因为RRID是从 中央数据库，被科学家在撰写论文时广泛使用，该门户还可以用作 传播有关这些试剂如何发挥作用的关键信息的中央中心。例如，RRID门户 提供关于由天龙提供的受污染细胞系的警告。然而，关于其他类型的此类信息 资源要分散得多。因此，我们建立了一个相关的知识库，资源观察， 增强有关RRID的信息。RRID项目是在现有的NIH资助的基础上启动的 项目，但鉴于其增长和对生物医学的重要性，我们寻求将目前的RRID项目统一为一个 自给自足实体。