权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Phase II: Fluorescence guided surgery standardization tools

第二阶段：荧光引导手术标准化工具

基本信息

批准号：
10664034
负责人：
Ethan Phillip Marshall LaRochelle
金额：
$ 97.4万
依托单位：
QUEL IMAGING LLC
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-30 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10664034
关键词：
3D Print Accounting Adopted Adoption Advocate Affect Blood Vessels Calibration Clinical Clinical Trials Collaborations Development Disease Ensure FDA approved Feedback Fluorescence Future Generations Genotype Geometry Growth Image Image Analysis Indocyanine Green Industry Ink Investigation Isosulfan Blue Letters Light Medical Medicine Methods Methylene blue Modeling Monitor Online Systems Operative Surgical Procedures Optics Paper Pathway interactions Performance Perfusion Phase Photobleaching Plant Resins Positioning Attribute Printing Procedures Production Property Protocols documentation Publishing Recommendation Reporting Resolution Running Services Signal Transduction Sodium Fluorescein Standardization Surface Surgeon Surgical Specialties System Techniques Technology Testing Time Tissues Tracer Translating Vendor Work absorption career networking contrast enhanced cost cost effective design experience fluorescence imaging fluorescence-guided surgery fluorophore imaging facilities imaging modality imaging system improved manufacture manufacturing capabilities manufacturing run manufacturing systems molecular phenotype novel optical imaging perfusion imaging phase III trial prevent quality assurance success targeted imaging tissue phantom tool web portal

项目摘要

Abstract Fluorescence-guided surgery is increasingly being adopted by surgeons for the potential to obtain real-time feedback, improving their ability to identify normal and diseased tissues through enhanced contrast. Yet, even with this growing adoption, there is a stark lack of standardized system characterization or routine performance monitoring, largely because the optical technologies vary considerably in their geometry, configuration, components and ultimately their uses. The lack of performance targets across vendors leads to a high inefficiency and irreproducibility between systems, and prevents the ability to exchange systems for the same use. One of the more complicated but critical factors with optical imaging in tissue is accounting for how tissue optical properties, spectral range and tissue layers/depths affect the image quality in non-linear and non- intuitive ways. QUEL Imaging has developed methods for printing optical reference targets with controlled optical properties and fluorescence inclusions of varying concentrations. In this application, we plan to expand these product offerings by incorporating new fluorophores and target designs. Our centralized web-portal will provide image analysis services to report metrics used for system characterization. Performance monitoring targets will be developed for the purpose of implementing QA protocols specific to imaging form-factors: endoscopic, close-box and open widefield systems. Our quality management system will be enhanced to align with ISO13485 and ensure NIST traceability of our products. New printing techniques will be explored to determine methods for further reducing production costs and improving scalability. This work will be supported and guided by a panel of industry, academic and medical experts who will meet bi-annually to discuss current and future needs to help better standardize this field.

摘要手术引导手术越来越多地被外科医生采用，以获得实时的反馈，提高他们的能力，以确定正常和病变组织通过增强对比度。但即使随着这一应用的不断增加，标准化的系统特性或常规性能的缺乏是显而易见的监测，主要是因为光学技术在它们的几何形状，配置，组件及其最终用途。供应商之间缺乏性能目标，系统之间的低效率和不可再现性，并且阻止了将系统交换为相同系统的能力使用.组织中光学成像的更复杂但关键的因素之一是考虑组织如何光学特性、光谱范围和组织层/深度以非线性和非线性方式影响图像质量。直觉的方式。QUEL Imaging开发了用于打印光学参考目标的方法，光学性质和不同浓度的荧光内含物。在这个应用程序中，我们计划扩展这些产品通过结合新的荧光团和目标设计。我们的中央门户网站将提供图像分析服务，以报告用于系统表征的指标。性能监控将开发目标，用于实施特定于成像形状因子的QA协议：内窥镜、闭箱和开放式宽视野系统。我们的质量管理体系将得到加强，符合ISO 13485标准，并确保我们产品的NIST可追溯性。将探索新的印刷技术，确定进一步降低生产成本和提高可扩展性的方法。这项工作将得到支持并由一个由工业界、学术界和医学专家组成的小组指导，他们将每两年举行一次会议，讨论当前的和未来的需要，以帮助更好地标准化这一领域。