Epidemiological and Statistical Methods Core (ESC)

流行病学和统计方法核心（ESC）

• 批准号: 10663941
• 负责人: KUNJAL PATEL
• 金额: $ 60.55万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-18 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663941
• 关键词: Acceleration; Address; Adolescent; Adult; Advanced Development; Bioinformatics; Birth; Brain region; Child; Childhood; Clinic; Clinical; Cognitive; Collaborations; Complex; Conceptions; Continuing Education; Correlation Studies; Data; Data Analyses; Databases; Development; Disease remission; E-learning; Education; Effectiveness; Environment; Epidemiologic Methods; Epidemiologist; Epidemiology; Epigenetic Process; Evaluation; Evaluation Studies; Faculty; Formulation; Fostering; Genes; Genetic; Genomics; Goals; Graph; Gynecologist; HIV; Health; Hearing; Image; Immunologist; Individual; Informatics; Language; Longevity; Measurement; Mediation; Mediator; Mental Health; Mentorship; Methodology; Methods; Modification; Monitor; Mothers; Nature; Neurologist; Observational Study; Oral health; Outcome; Outcome Study; Parameter Estimation; Pediatric HIV/AIDS Cohort Study; Pediatric epidemiology; Perinatal; Perinatal Epidemiology; Persons; Population Intervention; Population Study; Pregnancy; Probability; Program Research Project Grants; Protocols documentation; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Safety; Sampling; Scheme; Series; Site; Social outcome; Source; Specialist; Specific qualifier value; Statistical Methods; Time; Toxic effect; Training; Weight; Youth; analytical method; analytical tool; behavioral outcome; career; case control; cohort; data resource; deep learning algorithm; design; emotion regulation; emotional behavior; health determinants; high dimensionality; in utero; informatics tool; innovation; interest; longitudinal design; microbiome; multidisciplinary; multilevel analysis; neuroimaging; novel; pediatric human immunodeficiency virus; pediatrician; perinatal HIV; prevent; programs; prospective; social; statistical service; tool; transmission process; young adult

PROJECT SUMMARY The Pediatric HIV/AIDS Cohort Study (PHACS) is a large-scale multi-site network with multiple observational studies aimed to evaluate the long-term effectiveness and safety of population-based interventions to prevent perinatal HIV transmission and HIV progression and inform HIV remission/cure strategies. The PHACS Research Projects have generated and will continue to gather data on health determinants from various sources and via diverse methods including clinical, social, genomic, microbiome, and imaging data. A multitude of concept sheets and sub-studies will therefore be proposed requiring specialized epidemiological and statistical expertise, ranging from efficient study design, causal inference methodology, deep learning algorithms, bioinformatics, and integrative microbiome informatics, to inform data analyses that will be conducted by the PHACS Data Resources Core (DRC). As we continue to add to our extensive PHACS database, new and challenging problems are likely to arise that may necessitate the development of innovative study designs and analytic methods, particularly in the fields of pediatric and perinatal epidemiology. Ongoing training will be required on these and other methodological innovations for PHACS epidemiologists and statisticians. Continuing education on fundamental epidemiological and statistical principles will also be required for all PHACS investigators in order to conduct effective collaborative research. To address these needs and promote valid and efficient pediatric and perinatal HIV research within the Research Projects and any focused Emerging Research Pilots, the PHACS Epidemiological and Statistical Methods Core (ESC) has been established to: (1) provide specialized epidemiological and statistical services, support, and resources; (2) promote the development and application of novel epidemiological and statistical methods; and (3) support continuing education in epidemiological and statistical methods through in-person or web-based training and mentorship of early career investigators.

项目摘要 儿科HIV/AIDS队列研究（PHACS）是一个大规模的多中心网络， 研究旨在评估以人群为基础的干预措施的长期有效性和安全性， 围产期艾滋病毒传播和艾滋病毒进展，并告知艾滋病毒缓解/治愈战略。PHACS 研究项目已经产生并将继续收集来自各种健康决定因素的数据， 来源和通过不同的方法，包括临床，社会，基因组，微生物组和成像数据。众多 因此，将提出一系列概念说明书和子研究，需要专门的流行病学和 统计专业知识，包括有效的研究设计，因果推理方法，深度学习 算法，生物信息学和综合微生物组信息学，为数据分析提供信息， 由PHACS数据资源核心（DRC）进行。随着我们继续增加我们广泛的PHACS 数据库，新的和具有挑战性的问题可能会出现，可能需要开发创新的 研究设计和分析方法，特别是在儿科和围产期流行病学领域。正在进行 需要对PHACS流行病学家进行关于这些和其他方法创新的培训， 统计学家。还将继续进行关于流行病学和统计学基本原则的教育， 所有PHACS研究者都需要进行有效的合作研究。 为了满足这些需求，并促进有效和高效的儿科和围产期艾滋病毒研究， 研究项目和任何重点新兴研究试点，PHACS流行病学和统计 方法建立流行病学中心（ESC）：（1）提供专业的流行病学和统计学服务， 支持和资源;（2）促进新的流行病学和统计学的发展和应用 方法;（3）通过面对面或面对面的方式支持流行病学和统计方法方面的继续教育， 对早期职业调查员进行网上培训和辅导。