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Epidemiological and Statistical Methods Core (ESC)

流行病学和统计方法核心（ESC）

基本信息

批准号：
10264957
负责人：
KUNJAL PATEL
金额：
$ 55.42万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-18 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10264957
关键词：
Address Adolescent Adult Advanced Development Bioinformatics Birth Brain region Child Childhood Clinic Clinical Cognitive Collaborations Complex Continuing Education Data Data Analyses Databases Development Disease remission E-learning Education Effectiveness Environment Epidemiologic Methods Epidemiologist Epidemiology Epigenetic Process Evaluation Evaluation Studies Faculty Formulation Fostering Genes Genetic Genomics Goals Graph Gynecologist HIV Health Hearing Image Immunologist Individual Informatics Intervention Language Longevity Measurement Mediation Mediator of activation protein Mental Health Mentorship Methodology Methods Mind Modification Monitor Mothers Nature Neurologist Observational Study Oral health Outcome Outcome Study Pediatric HIV/AIDS Cohort Study Pediatric epidemiology Perinatal Epidemiology Persons Population Study Pregnancy Pregnancy Interval Probability Program Research Project Grants Protocols documentation Research Research Design Research Personnel Research Project Grants Resources Risk Safety Sampling Scheme Series Site Social outcome Source Specialist Specific qualifier value Statistical Methods Time Toxic effect Training Weight Youth analytical method analytical tool behavioral outcome career case control cohort data resource deep learning algorithm design emotion regulation emotional behavior high dimensionality in utero informatics tool innovation interest longitudinal design microbiome multidisciplinary multilevel analysis neuroimaging novel pediatric human immunodeficiency virus pediatrician perinatal HIV population based prevent programs prospective social social genomics statistical service tool transmission process young adult

项目摘要

PROJECT SUMMARY The Pediatric HIV/AIDS Cohort Study (PHACS) is a large-scale multi-site network with multiple observational studies aimed to evaluate the long-term effectiveness and safety of population-based interventions to prevent perinatal HIV transmission and HIV progression and inform HIV remission/cure strategies. The PHACS Research Projects have generated and will continue to gather data on health determinants from various sources and via diverse methods including clinical, social, genomic, microbiome, and imaging data. A multitude of concept sheets and sub-studies will therefore be proposed requiring specialized epidemiological and statistical expertise, ranging from efficient study design, causal inference methodology, deep learning algorithms, bioinformatics, and integrative microbiome informatics, to inform data analyses that will be conducted by the PHACS Data Resources Core (DRC). As we continue to add to our extensive PHACS database, new and challenging problems are likely to arise that may necessitate the development of innovative study designs and analytic methods, particularly in the fields of pediatric and perinatal epidemiology. Ongoing training will be required on these and other methodological innovations for PHACS epidemiologists and statisticians. Continuing education on fundamental epidemiological and statistical principles will also be required for all PHACS investigators in order to conduct effective collaborative research. To address these needs and promote valid and efficient pediatric and perinatal HIV research within the Research Projects and any focused Emerging Research Pilots, the PHACS Epidemiological and Statistical Methods Core (ESC) has been established to: (1) provide specialized epidemiological and statistical services, support, and resources; (2) promote the development and application of novel epidemiological and statistical methods; and (3) support continuing education in epidemiological and statistical methods through in-person or web-based training and mentorship of early career investigators.

项目总结