Reduced EtO emissions to safeguard biomedical supply chains

减少环氧乙烷排放以保护生物医学供应链

• 批准号: 10547016
• 负责人: Melissa A Petruska
• 金额: $ 20万
• 依托单位: SONATA SCIENTIFIC, LLC
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10547016
• 关键词: Reduced; EtO; emissions; safeguard; biomedical

Summary/Abstract The overarching goal of this project is to protect the nation’s supply chain of critical medical devices that are sterilized using ethylene oxide (EtO). Despite the search for alternative approaches, numerous types of single-use devices are sterilized with EtO. These devices, including catheters, heart valves, and tracheostomy tubes, are critical to routine and life-saving procedures and therapies. As regulation of EtO emissions and community and worker exposure levels continues to become more stringent, there is a threat that supply chains for critical devices will be disrupted, in turn threatening the health and well-being of the nation. The specific objectives of this project include the development of a novel photocatalytic method to mitigate EtO at levels that are hazardous but difficult to address with existing adsorptive and thermal catalytic approaches. Specifically, the technology addresses concentrations in the range of 10 ppm and below. The technology can be used to mitigate EtO from existing sterilization plants as an adjunct to stack scrubbers, as well as deployed to address ambient levels of EtO in plants and warehouses. Objectives include determining operating conditions at which low concentrations of EtO (<10 ppm) are oxidized at 99% destruction and removal efficiency (DRE), identifying optimum photocatalyst and parameter space for achieving high DRE, developing a prototype photoreactor operating at 20 cfm capable of 99% EtO DRE that is scalable to commercial requirements, and evaluating the performance of the prototype for a target 99% EtO DRE at 20 cfm. The specific aims are determining operating parameters at lab-scale, building a scalable prototype reactor capable of 20 cfm operation, and evaluating the performance of the prototype at 20 cfm for a target of 99% EtO DRE. Study designs are centered around systematic catalyst modifications and exploration of gas flow / illumination geometries. Standard and cutting-edge detection approaches that are capable of measuring EtO into the low ppb and ppt ranges will be used in the experimental program.

总结/摘要 该项目的总体目标是保护国家的关键医疗供应链， 使用环氧乙烷（EtO）灭菌的器械。尽管寻找替代品 在这些方法中，许多类型的一次性使用器械均采用环氧乙烷灭菌。这些设备， 包括导管、心脏瓣膜和气管切开插管，对日常生活和挽救生命至关重要。 程序和治疗。作为EtO排放以及社区和工人暴露的法规 水平继续变得更加严格，关键设备的供应链面临威胁， 将受到干扰，进而威胁到国家的健康和福祉。具体 该项目的目标包括开发一种新的光催化方法， EtO处于危险水平，但难以通过现有的吸附和热处理解决 催化方法。具体而言，该技术解决了10 ppm范围内的浓度 及以下该技术可用于减少现有灭菌工厂的EtO， 辅助堆叠洗涤器，并部署用于解决工厂中环氧乙烷的环境水平， 仓库目标包括确定低浓度的 环氧乙烷（<10 ppm）在99%的破坏和去除效率（DRE）下被氧化， 最佳的光催化剂和参数空间，以实现高DRE，开发原型 在20 cfm下运行的光反应器，能够实现99%的EtO DRE，可扩展至商业 要求，并评价原型在20 ℃下达到99% EtO DRE目标的性能 cfm。具体目标是在实验室规模上确定操作参数， 能够20 cfm运行的原型反应堆，并评估原型的性能 在20 cfm下，目标EtO DRE为99%。研究设计围绕系统催化剂 气体流动/照明几何形状的修改和探索。标准和尖端 能够将EtO测量到低ppb和ppt范围的检测方法将 用于实验项目。