Optimizing evidence-based HIV prevention targeting people who inject drugs on PrEP

针对 PrEP 注射吸毒者优化基于证据的艾滋病毒预防

基本信息

  • 批准号:
    10548320
  • 负责人:
  • 金额:
    $ 60.56万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-01 至 2027-06-30
  • 项目状态:
    未结题

项目摘要

Framed by the multiphase optimization strategy (MOST), and building on our recent preliminary studies, we are requesting 5 years of support to conduct an optimization trial among people who inject drugs (PWID) and newly enrolled on medication for opioid use disorder (MOUD). The goal is to assess the performance of four intervention components (Attention, Executive Functioning, Memory, and Information Processing) aimed at enhancing the ability of PWID on MOUD to process and utilize evidence-based HIV prevention content, leading to improvements in Pre-Exposure Prophylaxis (PrEP) adherence and HIV risk reduction. Existing evidence-based interventions require participants to have at least moderate levels of cognitive functioning but do not acknowledge or accommodate participants with cognitive dysfunction. This is a crucial weakness as cognitive dysfunction is a common feature among PWID, and one that can directly impede their ability to process and utilize intervention content. In fact, our recent studies comparing objective and self-report cognitive assessments (e.g., NIH toolbox) show that ~67% of PWID experience substantial levels of cognitive dysfunction across tasks involving attention, executive function, memory, and information processing that, in turn, disrupt the expected intervention outcomes (e.g., medication adherence, HIV risk reduction). Our recent work also suggests that PWID newly enrolled on MOUD would benefit from an intervention approach that incorporates ‘compensatory strategies’ to accommodate their cognitive dysfunction. A number of well-established compensatory strategies have been successfully applied to other patient populations (e.g., traumatic brain injury, ADHD, Alzheimer’s/dementia) and have been identified by our team as promising intervention components that could enhance evidence-based PrEP-focused primary HIV prevention approaches targeting PWID on MOUD. To date, however, no studies have examined the potential impact and cost of incorporating such intervention components, either individually or in various combinations, in terms of enhancing PWID’s ability to process and utilize HIV prevention content. This innovative trial will be the first to use the MOST framework to optimize an evidence-based HIV prevention approach by compensating for cognitive features that are characteristic of PWID on MOUD, and maximizing PrEP adherence outcomes within real world budget constraints.
以多阶段优化策略(MOST)为框架,以我们最近的研究成果为基础

项目成果

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MICHAEL COPENHAVER其他文献

MICHAEL COPENHAVER的其他文献

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{{ truncateString('MICHAEL COPENHAVER', 18)}}的其他基金

Optimizing evidence-based HIV prevention targeting people who inject drugs on PrEP
针对 PrEP 注射吸毒者优化基于证据的艾滋病毒预防
  • 批准号:
    10818897
  • 财政年份:
    2022
  • 资助金额:
    $ 60.56万
  • 项目类别:
Optimizing HIV Prevention Among Opioid-Dependent Persons
优化阿片类药物依赖者的艾滋病毒预防
  • 批准号:
    10425302
  • 财政年份:
    2020
  • 资助金额:
    $ 60.56万
  • 项目类别:
Optimizing HIV Prevention Among Opioid-Dependent Persons
优化阿片类药物依赖者的艾滋病毒预防
  • 批准号:
    10652562
  • 财政年份:
    2020
  • 资助金额:
    $ 60.56万
  • 项目类别:
Optimizing HIV Prevention Among Opioid-Dependent Persons
优化阿片类药物依赖者的艾滋病毒预防
  • 批准号:
    10217091
  • 财政年份:
    2020
  • 资助金额:
    $ 60.56万
  • 项目类别:
Optimizing HIV Prevention Among Opioid-Dependent Persons
优化阿片类药物依赖者的艾滋病毒预防
  • 批准号:
    10083001
  • 财政年份:
    2020
  • 资助金额:
    $ 60.56万
  • 项目类别:
Testing an integrated bio-behavioral primary HIV prevention intervention among high-risk people who use drugs
在吸毒高危人群中测试综合生物行为艾滋病毒初级预防干预措施
  • 批准号:
    10197074
  • 财政年份:
    2017
  • 资助金额:
    $ 60.56万
  • 项目类别:
Testing an integrated bio-behavioral primary HIV prevention intervention among high-risk people who use drugs
在吸毒高危人群中测试综合生物行为艾滋病毒初级预防干预措施
  • 批准号:
    9410858
  • 财政年份:
    2017
  • 资助金额:
    $ 60.56万
  • 项目类别:
HIV Prevention and Adherence Among Priority Drug Using Populations
优先吸毒人群的艾滋病毒预防和依从性
  • 批准号:
    8628827
  • 财政年份:
    2013
  • 资助金额:
    $ 60.56万
  • 项目类别:
HIV Prevention and Adherence Among Priority Drug Using Populations
优先吸毒人群的艾滋病毒预防和依从性
  • 批准号:
    8812787
  • 财政年份:
    2013
  • 资助金额:
    $ 60.56万
  • 项目类别:
HIV Prevention and Adherence Among Priority Drug Using Populations
优先吸毒人群的艾滋病毒预防和依从性
  • 批准号:
    8541232
  • 财政年份:
    2013
  • 资助金额:
    $ 60.56万
  • 项目类别:
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