Temporal Specification of Basal Forebrain Circuitry

基底前脑回路的时间规范

基本信息

项目摘要

Project Summary The septum is a structure in the basal forebrain that has critical roles in regulating emotional states including fear, anxiety and depression. Despite our growing appreciation for the importance of lateral septal circuit function in modulating emotional states, we know very little about the specific functions of the diverse septal neuron cell types and even less about the developmental mechanisms that create this diversity. We have identified the transcriptional regulator Prdm16 (Positive Regulatory Domain- containing 16), as being a critical component for regulating the production of distinct subtypes of neurons in the lateral septum. Our studies of Prdm16 serve as an entry point to understanding the relevant genetic programs and progenitor types regulating the development and specification of diverse septal neuron subtypes. In this proposal we plan to utilize single-cell RNA sequencing to map the developmental trajectories and overall diversity of neuronal cell types in the septum. The results from these studies will provide a foundation for understanding the development and function of temporally specified septum neuron types, and their contribution to behavioral circuits.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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COREY C HARWELL其他文献

COREY C HARWELL的其他文献

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{{ truncateString('COREY C HARWELL', 18)}}的其他基金

The impact of early life opioid exposure on the molecular and functional trajectories of septal cell types
生命早期阿片类药物暴露对隔膜细胞类型分子和功能轨迹的影响
  • 批准号:
    10775154
  • 财政年份:
    2023
  • 资助金额:
    $ 42.54万
  • 项目类别:
Sonic Hedgehog Dependent Neuron-Astrocyte Crosstalk During Cortical Circuit Assembly
皮质电路组装过程中声波刺猬依赖性神经元-星形胶质细胞串扰
  • 批准号:
    10307403
  • 财政年份:
    2023
  • 资助金额:
    $ 42.54万
  • 项目类别:
Epigenetic Regulation of Cortical Neuronal Lineage Progression
皮质神经元谱系进展的表观遗传调控
  • 批准号:
    10570771
  • 财政年份:
    2022
  • 资助金额:
    $ 42.54万
  • 项目类别:
Temporal Specification of Basal Forebrain Circuitry
基底前脑回路的时间规范
  • 批准号:
    10574587
  • 财政年份:
    2022
  • 资助金额:
    $ 42.54万
  • 项目类别:
Epigenetic Regulation of Cortical Neuronal Lineage Progression
皮质神经元谱系进展的表观遗传调控
  • 批准号:
    10204129
  • 财政年份:
    2017
  • 资助金额:
    $ 42.54万
  • 项目类别:
Epigenetic Regulation of Cortical Neuronal Lineage Progression
皮质神经元谱系进展的表观遗传调控
  • 批准号:
    9362098
  • 财政年份:
    2017
  • 资助金额:
    $ 42.54万
  • 项目类别:
Regulation of Cortical Circuit Development by Sonic Hedgehog Signaling
声波刺猬信号对皮层回路发育的调节
  • 批准号:
    8926481
  • 财政年份:
    2014
  • 资助金额:
    $ 42.54万
  • 项目类别:
Regulation of Cortical Circuit Development by Sonic Hedgehog Signaling
声波刺猬信号对皮质回路发育的调节
  • 批准号:
    8804533
  • 财政年份:
    2014
  • 资助金额:
    $ 42.54万
  • 项目类别:

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