Temporal Specification of Basal Forebrain Circuitry
基底前脑回路的时间规范
基本信息
- 批准号:10550094
- 负责人:
- 金额:$ 42.54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-01 至 2024-02-29
- 项目状态:已结题
- 来源:
- 关键词:AddressAggressive behaviorAllium cepaAnxietyBehaviorBehavioralBipolar DepressionBipolar DisorderBirth OrderBrain regionCellsCompetenceDevelopmentDevelopmental GeneElectrophysiology (science)EmbryoEmotionalFoundationsFrightFunctional disorderGene ExpressionGenesGeneticGenetic TranscriptionGoalsHippocampus (Brain)HistologyKnockout MiceLateralLeadLogicMapsMedialMediatingMental DepressionMental disordersMolecularMolecular GeneticsMolecular ProfilingMoodsMotivationNeuronsPathway interactionsPatternPlayProcessProductionRabies virusResearch ProposalsRoleSchizophreniaSeptal NucleiSkinSourceSpecific qualifier valueStructureSubgroupTechniquesTestingTimebasal forebraincell typecholinergiccohortconditional knockoutinsightinterdisciplinary approachneurogenesisneuropsychiatric disordernew therapeutic targetprogenitorprogramssequencing platformsingle-cell RNA sequencingtreatment strategy
项目摘要
Project Summary
The septum is a structure in the basal forebrain that has critical roles in regulating
emotional states including fear, anxiety and depression. Despite our growing appreciation
for the importance of lateral septal circuit function in modulating emotional states, we know
very little about the specific functions of the diverse septal neuron cell types and even less
about the developmental mechanisms that create this diversity. We have identified the
transcriptional regulator Prdm16 (Positive Regulatory Domain- containing 16), as being a
critical component for regulating the production of distinct subtypes of neurons in the lateral
septum. Our studies of Prdm16 serve as an entry point to understanding the relevant
genetic programs and progenitor types regulating the development and specification of
diverse septal neuron subtypes. In this proposal we plan to utilize single-cell RNA
sequencing to map the developmental trajectories and overall diversity of neuronal cell
types in the septum. The results from these studies will provide a foundation for
understanding the development and function of temporally specified septum neuron types,
and their contribution to behavioral circuits.
项目摘要
隔膜是基底前脑中的一个结构,在调节
情绪状态包括恐惧焦虑和抑郁尽管我们越来越欣赏
对于侧隔回路功能在调节情绪状态中的重要性,我们知道,
关于不同隔神经元细胞类型的具体功能,
创造这种多样性的发展机制。我们已经确定了
转录调节因子Prdm 16(含有正调节结构域的16),作为一种转录调节因子,
调节外侧神经元不同亚型产生的关键成分
隔膜我们对Prdm16的研究是了解相关
遗传程序和祖细胞类型调节的发展和规范
不同的隔神经元亚型。在这项提案中,我们计划利用单细胞RNA
测序以绘制神经元细胞的发育轨迹和总体多样性
隔膜中的类型。这些研究的结果将为
了解时间上特定的隔神经元类型的发育和功能,
以及它们对行为回路的贡献
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('COREY C HARWELL', 18)}}的其他基金
The impact of early life opioid exposure on the molecular and functional trajectories of septal cell types
生命早期阿片类药物暴露对隔膜细胞类型分子和功能轨迹的影响
- 批准号:
10775154 - 财政年份:2023
- 资助金额:
$ 42.54万 - 项目类别:
Sonic Hedgehog Dependent Neuron-Astrocyte Crosstalk During Cortical Circuit Assembly
皮质电路组装过程中声波刺猬依赖性神经元-星形胶质细胞串扰
- 批准号:
10307403 - 财政年份:2023
- 资助金额:
$ 42.54万 - 项目类别:
Epigenetic Regulation of Cortical Neuronal Lineage Progression
皮质神经元谱系进展的表观遗传调控
- 批准号:
10570771 - 财政年份:2022
- 资助金额:
$ 42.54万 - 项目类别:
Temporal Specification of Basal Forebrain Circuitry
基底前脑回路的时间规范
- 批准号:
10574587 - 财政年份:2022
- 资助金额:
$ 42.54万 - 项目类别:
Epigenetic Regulation of Cortical Neuronal Lineage Progression
皮质神经元谱系进展的表观遗传调控
- 批准号:
10204129 - 财政年份:2017
- 资助金额:
$ 42.54万 - 项目类别:
Epigenetic Regulation of Cortical Neuronal Lineage Progression
皮质神经元谱系进展的表观遗传调控
- 批准号:
9362098 - 财政年份:2017
- 资助金额:
$ 42.54万 - 项目类别:
Regulation of Cortical Circuit Development by Sonic Hedgehog Signaling
声波刺猬信号对皮层回路发育的调节
- 批准号:
8926481 - 财政年份:2014
- 资助金额:
$ 42.54万 - 项目类别:
Regulation of Cortical Circuit Development by Sonic Hedgehog Signaling
声波刺猬信号对皮质回路发育的调节
- 批准号:
8804533 - 财政年份:2014
- 资助金额:
$ 42.54万 - 项目类别:
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