Expansion and Characterization of Relevant Simian Immunodeficiency Virus (SIV) Stocks for Use in Drug Assays or Repeat, Low-Dose Challenge Studies in Rhesus Macaques

用于恒河猴药物测定或重复、低剂量攻击研究的相关猿猴免疫缺陷病毒 (SIV) 库存的扩展和表征

• 批准号: 10551010
• 负责人: PETER SILVERA
• 金额: $ 8.36万
• 依托单位: ADVANCED BIOSCIENCE LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-16 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10551010
• 关键词: Animal Model; Biological Assay; Collaborations; Contractor; Contracts; Dose; HIV; In Vitro; Investigator-Initiated Research; Macaca mulatta; National Institute of Allergy and Infectious Disease; Nucleosides; Pharmaceutical Preparations; Prevention; RNA-Directed DNA Polymerase; Resources; SIV; Services; Titrations; Vagina; Virus; Virus Diseases; in vivo; inhibitor; microbicide; pre-clinical; product development; research study

The purpose of the Comprehensive Resources for Microbicides and Biomedical Prevention contract is to provide the NIAID with a comprehensive suite of preclinical product development services for candidate products that emerge from investigator-initiated research studies or from collaborations with outside companies or organizations. The Contractor shall provide: 1) Preclinical gap-filling services; 2) HIV animal models supporting product development; 3) Bioanalytical support services; 4) Product manufacturing; and 5) Scientific and quality/regulatory support services.

杀微生物剂和生物医学预防综合资源合同的目的是为 NIAID 提供一整套临床前产品开发服务，用于针对研究者发起的研究或与外部公司或组织合作产生的候选产品。承包商应提供： 1) 临床前填补服务； 2）支持产品开发的HIV动物模型； 3）生物分析支持服务； 4）产品制造； 5) 科学和质量/监管支持服务。