Pilot Projects Program

试点项目计划

• 批准号: 10630392
• 负责人: Patrycja Marta Dubielecka-Szczerba
• 金额: $ 19.68万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630392
• 关键词: Acceleration; Aging; Award; Basic Science; Biological Sciences; Biology of Aging; Cancer Center; Caring; Centers of Research Excellence; Clinic; Clinical; Clinical Data; Clinical Trials; Collaborations; Communities; Core Facility; Data Analyses; Development; Disease; Early identification; Education; Ensure; Evaluation; Event; Extramural Activities; Feasibility Studies; Flow Cytometry; Fostering; Funding; Funding Mechanisms; Goals; Grant; Healthcare; Hospitals; Infrastructure; Institution; Longevity; Measures; Mentors; Mentorship; Methodology; New England; Outcome; Outcome Measure; Phase; Pilot Projects; Play; Population; Prevention strategy; Program Reviews; Regenerative Medicine; Reproducibility; Request for Proposals; Research; Research Personnel; Resources; Rhode Island; Role; Science; Scientist; Secure; Services; Strategic Planning; Structure; Technology; Time; Tissues; Training; Translating; Translations; Underrepresented Populations; Underrepresented Students; United States National Institutes of Health; Universities; Vision; Wages; Work; age related; biobank; clinical practice; design; extracellular vesicles; graduate student; instrumentation; inter-institutional; medical schools; member; multidisciplinary; primary outcome; professor; programs; recruit; service programs; stem cells; success; synergism; translational approach; translational impact; translational potential; translational scientist; undergraduate student; voucher

PROGRAM SUMMARY/ABSTRACT - STEM CELL AND AGING COBRE PILOT GRANT PROGRAM Building on the success of our Phase 1 and 2 COBRE program, we propose the Stem Cells and Aging (SCA) COBRE Pilot Grants Program with an objective to recruit promising teams of early-stage investigators by providing a funding mechanism for pilot projects and provide intellectual, technical and instrumental infrastructure. In Specific Aim 1, we will select teams of translational researchers (consisting of basic and clinical scientists, with at least one early-stage investigator) for 3 pilot project awards ($50,000 per year for 2 years and minimum of 6 awards for the duration of the program), with additional summer stipends for students from under- represented groups to enhance diversity. The request for proposals will focus on projects with high potential of translating basic research into clinical practice. In Specific Aim 2, we will provide structured, formal mentorship (provided by senior, extramurally-funded investigators) for participating early-stage basic- and clinician-scientist investigators focused on stem cell and aging research, regenerative medicine and age-related diseases to facilitate their transition to research independence with extramural funding. In Specific Aim 3, we will promote the utilization and sustainability of the SCA COBRE Core Facilities (developed in Phases 1 and 2, and including Flow Cytometry, Extracellular Vesicles, Lentiviral Construct Core Facilities) through their utilization in the pilot projects as well as through vouchers to affiliated scientists participating in the program. In the Specific Aim 4, we will provide post-award mentorship, advisory and grantsmanship services for program awardees, and synergize efforts to transform funded projects into competitive applications at the R01 or equivalent level. Emphasis will be placed on rigorous, reproducible science with analysis supported by expert biostatisticians guiding the participating researchers. The core of the program will rely on the work of the SCA Pilot Grants Program Steering Committee who will provide mentoring and oversight and engage (for identification of early-stage investigators, for review of the pilot awards, and expert mentorship) the community of researchers across the multi-institutional consortium encompassing Brow University (Center of the Biology of Aging, Brown and Lifespan Cancer Centers), the Warren Alpert Medical School, the clinical experts from the Lifespan healthcare/Rhode Island Hospital and from Care new England. By establishing a multidisciplinary scientific infrastructure providing access to state-of- the-art instrumentation and technologies, as well as rigorous mentorship, advising, review and outcome guidance, the Phase 3 SCA COBRE Pilot Grant Program will contribute to expansion and transformation the biomedical and educational landscape within Rhode Island, creating a premier national center for research on stem cell, aging, and regenerative medicine. We will evaluate the program using outcome measures that include number and quality of submissions (measured by review scores), mentor and investigator evaluations and diversity of applicants and success in securing extramural awards.

干细胞和老化眼镜蛇试点资助计划 在我们的第一阶段和第二阶段COBRE计划成功的基础上，我们提出了干细胞和衰老（SCA） COBRE试点赠款计划，目标是通过以下方式招募有前途的早期研究人员团队： 为试点项目提供资金机制，并提供知识、技术和工具 基础设施演进在具体目标1中，我们将选择翻译研究人员团队（包括基础和临床研究人员）， 科学家，至少有一名早期研究员），获得3个试点项目奖（两年，每年50 000美元， 最低的6个奖项的程序的持续时间），与额外的夏季津贴的学生从下- 代表群体以增强多样性。招标书将侧重于具有高潜力的项目， 将基础研究转化为临床实践。在具体目标2中，我们将提供结构化的正式指导 （由资深的、校外资助的研究者提供），供参与的早期基础科学家和临床科学家使用 研究人员专注于干细胞和衰老研究，再生医学和与年龄有关的疾病， 促进他们过渡到研究独立与校外资助。在具体目标3中，我们将促进 SCA COBRE核心设施（在第1和第2阶段开发，包括 流式细胞术、细胞外囊泡、慢病毒构建核心设施）通过其在中试中的应用 项目以及通过凭证参加该计划的附属科学家。在第四个目标中，我们 将为项目获奖者提供奖后指导、咨询和资助服务， 努力将受资助的项目转化为R 01或同等水平的竞争性应用。重点将 严格的，可重复的科学与分析支持的专家生物统计学家指导， 参与的研究人员。该计划的核心将依赖于SCA试点赠款计划指导的工作 委员会将提供指导和监督，并参与（确定早期调查人员， 审查试点奖励和专家指导）跨多机构的研究人员社区 包括布朗大学（衰老生物学中心，布朗和终身癌症中心）， 沃伦·阿尔珀特医学院，来自Lifespan医疗保健/罗得岛医院的临床专家， 来自关怀新英格兰。通过建立多学科科学基础设施， 最先进的仪器和技术，以及严格的指导，建议，审查和成果 在指导下，第三阶段SCA COBRE试点赠款计划将有助于扩大和改造 生物医学和教育景观内罗得岛，创建一个首屈一指的国家研究中心， 干细胞、衰老和再生医学。我们将使用以下结果指标评估该计划，包括 提交材料的数量和质量（以评审分数衡量）、导师和研究者评价， 申请人的多样性和获得校外奖项的成功。