Mitochondrial Function and In Vivo Imaging Core

线粒体功能和体内成像核心

• 批准号: 10630738
• 负责人: Peng Zhang
• 金额: $ 22.55万
• 依托单位: OCEAN STATE RESEARCH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630738
• 关键词: Acute Respiratory Distress Syndrome; Animal Model; Animals; Atherosclerosis; Biological Process; Biology; Biomedical Research; Blood Vessels; Bronchopulmonary Dysplasia; Cardiopulmonary; Centers of Research Excellence; Collaborations; Communities; Coronary Arteriosclerosis; Data; Development; Disease Progression; Echocardiography; Energy Metabolism; Equipment; Fostering; Goals; Heart Injuries; Imaging technology; Incidence; Interruption; Intervention; Lasers; Mission; Mitochondria; Modernization; Morbidity - disease rate; Myocardial Infarction; Pathogenesis; Phase; Pilot Projects; Play; Positron-Emission Tomography; Prevention; Procedures; Process; Productivity; Pulmonary Fibrosis; Pulmonary Heart Disease; Pulmonary Hypertension; Reproducibility; Research; Research Personnel; Resolution; Rhode Island; Role; Scientist; Services; System; Systemic hypertension; Technology; Time Study; Translational Research; United States; heart function; imager; in vivo imaging; injury and repair; innovation; instrument; inter-institutional; interest; lung injury; microCT; mitochondrial dysfunction; mortality; pre-clinical; preclinical study; programs; pulmonary function; repaired; respiratory; tool; vascular injury

The Mitochondrial Function and In Vivo Imaging (MF-II) Core The overall goal of the CardioPulmonary Vascular Biology (CPVB) COBRE program is to facilitate high impact vascular biology research. The CPVB COBRE has successfully supported numerous innovative studies for a better understanding of the pathogenesis and the associated mechanisms of cardiopulmonary diseases. Over these years, there has been increasing interest and requests from the CPVB COBRE investigators and other scientists to perform mitochondrial function assessments and high-resolution in vivo imaging in preclinical studies. The Mitochondrial Function and In Vivo Imaging (MF-II) Core has evolved from the Respiratory Core that was established in 2021 as the 2nd technical core of the CPVB COBRE based on user needs. The mission of the MF-II Core is to develop a centralized system for mitochondrial function assessments and high-resolution in vivo imaging, with the goals to enhance productivity, promote interdisciplinary and inter-institutional collaborations, and increase research impact of the CPVB COBRE investigators and other investigators in the state of Rhode Island. To date, the Respiratory/MF-II Core have served 30 unique users with 4,030 services. There is a ~2.2-fold increase in yearly technical core services from the Phase I to the Phase II. In Phase III, the overall objective of the MF-II Core is to facilitate the scientific objectives and technical repertoire of the CPVB COBRE Pilot Project Investigators and other Rhode Island and IDeA investigators by providing centralized cutting-edge technologies and essential services. The specific aims of the MF-II Core are to: i) offer effective, reproducible, and economical services in high- resolution in vivo imaging and mitochondria function assessments to pilot project investigators and the scientific community; ii) acquire, establish, and disseminate technologies and instrument capabilities to provide state of the art research tools for pilot project investigators and the scientific community; iii) facilitate interdisciplinary and inter-institutional collaborations by providing technical services to enhance research productivity, and to foster scientific networks by closely working with IDeA programs in Rhode Island and other states; iv) establish processes and procedures that lead to sustainability of the MF-II Core. The MF-II Core will continue to provide critical support to investigators in Phase III and beyond to augment and strengthen biomedical research excellence in the state of Rhode Island and the other IDeA states.

线粒体功能和体内成像（MF-II）核心 肺血管生物学（CPVB）COBRE计划的总体目标是促进高影响力 血管生物学研究。CPVB COBRE成功支持了许多创新研究， 更好地了解心肺疾病的发病机制和相关机制。超过 这些年来，CPVB COBRE调查人员和其他研究人员的兴趣和要求越来越多， 科学家在临床前进行线粒体功能评估和高分辨率体内成像 问题研究线粒体功能和体内成像（MF-II）核心由呼吸核心演变而来 根据用户需求，于2021年成立CPVB COBRE第二技术核心。使命 MF-II核心的核心是开发一个集中的系统，用于线粒体功能评估和高分辨率 体内成像，目标是提高生产力，促进跨学科和跨机构 合作，并增加CPVB COBRE研究人员和其他研究人员在 美国罗得岛州。到目前为止，呼吸/MF-II核心已经为30个独立用户提供了4，030项服务。 从第一阶段到第二阶段，每年的技术核心服务增加了约2.2倍。在第三阶段， MF-II核心的总体目标是促进CPVB的科学目标和技术储备 COBRE试点项目研究者和其他罗得岛和IDEA研究者通过提供集中的 尖端技术和基本服务。 MF-II核心的具体目标是：i）提供高效，可重复和经济的服务， 分辨率在体内成像和线粒体功能评估试点项目的研究人员和科学家， （二）获取、建立和传播技术和仪器能力， 为试点项目调查人员和科学界提供的艺术研究工具; iii）促进跨学科和 机构间合作，提供技术服务，以提高研究生产力， 通过与罗得岛和其他州的IDEA项目密切合作，建立科学网络; iv）建立 导致MF-II核心可持续性的过程和程序。MF-II核心将继续提供 为III期及以后的研究者提供关键支持，以扩大和加强生物医学研究 在罗得岛州和其他IDEA州的卓越表现。