权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Mitochondrial Function and In Vivo Imaging Core

线粒体功能和体内成像核心

基本信息

批准号：
10630738
负责人：
Peng Zhang
金额：
$ 22.55万
依托单位：
OCEAN STATE RESEARCH INSTITUTE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-01 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10630738
关键词：
Acute Respiratory Distress Syndrome Animal Model Animals Atherosclerosis Biological Process Biology Biomedical Research Blood Vessels Bronchopulmonary Dysplasia Cardiopulmonary Centers of Research Excellence Collaborations Communities Coronary Arteriosclerosis Data Development Disease Progression Echocardiography Energy Metabolism Equipment Fostering Goals Heart Injuries Imaging technology Incidence Interruption Intervention Lasers Mission Mitochondria Modernization Morbidity - disease rate Myocardial Infarction Pathogenesis Phase Pilot Projects Play Positron-Emission Tomography Prevention Procedures Process Productivity Pulmonary Fibrosis Pulmonary Heart Disease Pulmonary Hypertension Reproducibility Research Research Personnel Resolution Rhode Island Role Scientist Services System Systemic hypertension Technology Time Study Translational Research United States heart function imager in vivo imaging injury and repair innovation instrument inter-institutional interest lung injury microCT mitochondrial dysfunction mortality pre-clinical preclinical study programs pulmonary function repaired respiratory tool vascular injury

项目摘要

The Mitochondrial Function and In Vivo Imaging (MF-II) Core The overall goal of the CardioPulmonary Vascular Biology (CPVB) COBRE program is to facilitate high impact vascular biology research. The CPVB COBRE has successfully supported numerous innovative studies for a better understanding of the pathogenesis and the associated mechanisms of cardiopulmonary diseases. Over these years, there has been increasing interest and requests from the CPVB COBRE investigators and other scientists to perform mitochondrial function assessments and high-resolution in vivo imaging in preclinical studies. The Mitochondrial Function and In Vivo Imaging (MF-II) Core has evolved from the Respiratory Core that was established in 2021 as the 2nd technical core of the CPVB COBRE based on user needs. The mission of the MF-II Core is to develop a centralized system for mitochondrial function assessments and high-resolution in vivo imaging, with the goals to enhance productivity, promote interdisciplinary and inter-institutional collaborations, and increase research impact of the CPVB COBRE investigators and other investigators in the state of Rhode Island. To date, the Respiratory/MF-II Core have served 30 unique users with 4,030 services. There is a ~2.2-fold increase in yearly technical core services from the Phase I to the Phase II. In Phase III, the overall objective of the MF-II Core is to facilitate the scientific objectives and technical repertoire of the CPVB COBRE Pilot Project Investigators and other Rhode Island and IDeA investigators by providing centralized cutting-edge technologies and essential services. The specific aims of the MF-II Core are to: i) offer effective, reproducible, and economical services in high- resolution in vivo imaging and mitochondria function assessments to pilot project investigators and the scientific community; ii) acquire, establish, and disseminate technologies and instrument capabilities to provide state of the art research tools for pilot project investigators and the scientific community; iii) facilitate interdisciplinary and inter-institutional collaborations by providing technical services to enhance research productivity, and to foster scientific networks by closely working with IDeA programs in Rhode Island and other states; iv) establish processes and procedures that lead to sustainability of the MF-II Core. The MF-II Core will continue to provide critical support to investigators in Phase III and beyond to augment and strengthen biomedical research excellence in the state of Rhode Island and the other IDeA states.

线粒体功能和体内成像（MF-II）核心