Mitochondrial Function and In Vivo Imaging Core

线粒体功能与活体成像(MF-II)核 心肺血管生物学(CPVB)COBRE计划的总体目标是促进高影响力 血管生物学研究。CPVB Cobre成功地支持了许多创新研究 更好地了解心肺疾病的发病机制和相关机制。完毕 近年来，CPVB Cobre调查人员和其他人的兴趣和要求越来越多 科学家将在临床前进行线粒体功能评估和高分辨率体内成像 学习。线粒体功能和活体成像(MF-II)核心是从呼吸核心进化而来的 它成立于2021年，是CPVB Cobre基于用户需求的第二个技术核心。这项使命 MF-II的核心是开发一个用于线粒体功能评估和高分辨率的集中式系统 活体成像，目标是提高生产率，促进跨学科和跨机构 合作，并增加CPVB Cobre调查员和其他调查员在 罗德岛州。到目前为止，呼吸/MF-II核心已经为30个独立用户提供了4030项服务。 从第一阶段到第二阶段，年度技术核心服务增加了约2.2倍。在第三阶段， MF-II核心的总体目标是促进CPVB的科学目标和技术剧目 科布雷试点项目调查员和其他罗德岛和IDEA调查员通过提供集中的 尖端技术和基本服务。 MF-II核心的具体目标是：i)提供高效、可重现和经济的服务 为试点项目调查人员和科学工作者提供体内成像分辨率和线粒体功能评估 社区；二)获取、建立和传播技术和工具能力，以提供 为试点项目调查人员和科学界提供艺术研究工具；三)促进跨学科和 通过提供技术服务进行机构间合作，以提高研究生产率，并促进 通过与罗德岛和其他州的IDEA项目密切合作，建立科学网络； 导致MF-II核心可持续性的过程和程序。MF-II核心将继续提供 在第三阶段及以后为研究人员提供关键支持，以增强和加强生物医学研究 罗德岛州和其他理想州的卓越之处。

The Mitochondrial Function and In Vivo Imaging (MF-II) Core The overall goal of the CardioPulmonary Vascular Biology (CPVB) COBRE program is to facilitate high impact vascular biology research. The CPVB COBRE has successfully supported numerous innovative studies for a better understanding of the pathogenesis and the associated mechanisms of cardiopulmonary diseases. Over these years, there has been increasing interest and requests from the CPVB COBRE investigators and other scientists to perform mitochondrial function assessments and high-resolution in vivo imaging in preclinical studies. The Mitochondrial Function and In Vivo Imaging (MF-II) Core has evolved from the Respiratory Core that was established in 2021 as the 2nd technical core of the CPVB COBRE based on user needs. The mission of the MF-II Core is to develop a centralized system for mitochondrial function assessments and high-resolution in vivo imaging, with the goals to enhance productivity, promote interdisciplinary and inter-institutional collaborations, and increase research impact of the CPVB COBRE investigators and other investigators in the state of Rhode Island. To date, the Respiratory/MF-II Core have served 30 unique users with 4,030 services. There is a ~2.2-fold increase in yearly technical core services from the Phase I to the Phase II. In Phase III, the overall objective of the MF-II Core is to facilitate the scientific objectives and technical repertoire of the CPVB COBRE Pilot Project Investigators and other Rhode Island and IDeA investigators by providing centralized cutting-edge technologies and essential services. The specific aims of the MF-II Core are to: i) offer effective, reproducible, and economical services in high- resolution in vivo imaging and mitochondria function assessments to pilot project investigators and the scientific community; ii) acquire, establish, and disseminate technologies and instrument capabilities to provide state of the art research tools for pilot project investigators and the scientific community; iii) facilitate interdisciplinary and inter-institutional collaborations by providing technical services to enhance research productivity, and to foster scientific networks by closely working with IDeA programs in Rhode Island and other states; iv) establish processes and procedures that lead to sustainability of the MF-II Core. The MF-II Core will continue to provide critical support to investigators in Phase III and beyond to augment and strengthen biomedical research excellence in the state of Rhode Island and the other IDeA states.