Console Upgrade for 4.7T PET-MRI Preclinical Scanner

项目摘要 需要资金用于升级现有的4.7特斯拉·布鲁克PET-MRI控制台。建议数 仪器将是促进新型PET和MR分子成像发展的关键部件 造影剂和弥散磁共振研究脑结构和神经通路连接。PET-MRI 扫描仪服务于由美国国立卫生研究院资助的包含多种生物医学学科的大型用户社区 包括纤维化、癌症、心脏病学、基因表达以及脑结构和功能研究。我们目前 为麻省理工学院/哈佛/麻省理工学院系统内以及大波士顿/剑桥地区的用户提供服务 区域。 请求的MRI控制台升级将替换即将结束的旧Avance III Bruker控制台 它的整个使用寿命。从2024年开始，Bruker Biospin将不再支持或服务Avance III游戏机。到期 在MRI控制台的时代，在过去的几年里，我们经历了许多设备故障，这些故障 导致扫描仪长时间停机。今后，此类设备故障将很难解决，因为 布鲁克将不再储备备件或维修这样的旧游戏机。请求的控制台升级将 因此，允许我们继续为当地由NIH资助的大型用户社区提供服务，并提供重要的分子 通过分子和大脑为快速扩大的用户群提供成像和脑结构成像能力 想象中的兴趣。 特别是，拟议的仪器将允许将PET-MRI工作流程与PET和MRI相结合 通过完美的图像重建和配准，在相同的软件环境中获取数据。在……里面 此外，改进的3D动态垫片、基于EPI的扩散序列和梯度线圈性能 将大大加强对脑弥散成像的研究。需要MR-PET的项目包括开发 磁共振成像(MRI)和正电子发射断层扫描(PET)分子造影剂 肝纤维化、心脏纤维化、肺纤维化、转移性乳腺癌、胃癌、 胰腺癌、炎症性疾病、亨廷顿病与基因的表观遗传调控 表情。需要增强磁共振成像能力的项目包括对大脑的高分辨率研究 神经组织微结构、脑神经血管偶联和神经递质受体的多模式研究 溶瘤的转运、心肌纤维化成像和化学交换饱和转移(CEST)MRI研究 病毒疗法。

Project Summary Funding is requested for an upgrade of an existing 4.7 Tesla Bruker PET-MRI console. The proposed instrument will be a crucial component in facilitating the development of novel PET and MR molecular imaging contrast agents and for diffusion MRI studies of brain structure and neural pathway connectivity. The PET-MRI scanner serves a large NIH-funded user community encompassing a wide variety of biomedical disciplines including fibrosis, cancer, cardialogy, gene expression, and brain structure and function studies. We currently serve users both within the MGH/Harvard/MIT system as well as from around the greater Boston/Cambridge region. The requested MRI console upgrade will replace an old Avance III Bruker console that is nearing the end of its usefull lifetime. Starting in 2024 Bruker Biospin will no longer support or service the Avance III console. Due to the age of the MRI console, we have had numerous equipment failures over the last few years which have caused significant scanner downtime. In the future, such equipment failures will be difficult to address since Bruker will no longer stock spare parts or service such old consoles. The requested console upgrade would therefore allow us to continue to serve the large local NIH-funded user community and offer important molecular imaging and brain structural imaging capabilities to the rapidly expanding user base with molecular and brain imaging interests. In particular, the proposed instrument would allow for integrated PET-MRI workflow with both PET and MRI data acquired in the same software environment with seemless image reconstruction and registration. In addition, the improved 3D dynamic shimming, EPI based diffusion sequences, and gradient coil performance will greatly enhance the brain diffusion MRI studies. Projects requiring MR-PET include the development of Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) contrast agents for molecular imaging of liver fibrogenesis, cardiac fibrosis, pulmnary fibrosis, metastatic breast cancer, gastric cancer, pancreatic adenocarcinoma, inflammatory diseases, Huntington’s Disease, and epigenetic regulation of gene expression. Projects requiring the enhanced MR imaging capabilities include high resolution studies of brain neural tissue microstructure, multimodal studies of brain neurovacular coupling and neurotransmitter receptor trafficking, cardiac fibrosis imaging, and Chemical Exchange Saturation Transfer (CEST) MRI studies of oncolytic virotherapy.