Console Upgrade for 4.7T PET-MRI Preclinical Scanner

4.7T PET-MRI 临床前扫描仪控制台升级

• 批准号: 10630520
• 负责人: CHRISTIAN T FARRAR
• 金额: $ 60万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630520
• 关键词: 3-Dimensional; Address; Age; Boston; Brain; Brain imaging; Chemicals; Communities; Computer software; Contrast Media; Coupling; Data; Development; Diffusion; Diffusion Magnetic Resonance Imaging; Discipline; Disease; Environment; Equipment Failure; Fibrosis; Funding; Future; Gene Expression; Gene Expression Regulation; Hepatic Fibrogenesis; Huntington Disease; Image; Inflammatory; Magnetic Resonance Imaging; Malignant Neoplasms; Metastatic breast cancer; Neural Pathways; Neurotransmitter Receptor; Pancreatic Adenocarcinoma; Performance; Positron-Emission Tomography; Resolution; Services; Structure; System; Tissues; United States National Institutes of Health; base; coronary fibrosis; epigenetic regulation; image reconstruction; image registration; imaging capabilities; improved; instrument; interest; malignant stomach neoplasm; molecular imaging; multimodality; neural; novel; oncolytic virotherapy; pre-clinical; structural imaging; trafficking

Project Summary Funding is requested for an upgrade of an existing 4.7 Tesla Bruker PET-MRI console. The proposed instrument will be a crucial component in facilitating the development of novel PET and MR molecular imaging contrast agents and for diffusion MRI studies of brain structure and neural pathway connectivity. The PET-MRI scanner serves a large NIH-funded user community encompassing a wide variety of biomedical disciplines including fibrosis, cancer, cardialogy, gene expression, and brain structure and function studies. We currently serve users both within the MGH/Harvard/MIT system as well as from around the greater Boston/Cambridge region. The requested MRI console upgrade will replace an old Avance III Bruker console that is nearing the end of its usefull lifetime. Starting in 2024 Bruker Biospin will no longer support or service the Avance III console. Due to the age of the MRI console, we have had numerous equipment failures over the last few years which have caused significant scanner downtime. In the future, such equipment failures will be difficult to address since Bruker will no longer stock spare parts or service such old consoles. The requested console upgrade would therefore allow us to continue to serve the large local NIH-funded user community and offer important molecular imaging and brain structural imaging capabilities to the rapidly expanding user base with molecular and brain imaging interests. In particular, the proposed instrument would allow for integrated PET-MRI workflow with both PET and MRI data acquired in the same software environment with seemless image reconstruction and registration. In addition, the improved 3D dynamic shimming, EPI based diffusion sequences, and gradient coil performance will greatly enhance the brain diffusion MRI studies. Projects requiring MR-PET include the development of Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) contrast agents for molecular imaging of liver fibrogenesis, cardiac fibrosis, pulmnary fibrosis, metastatic breast cancer, gastric cancer, pancreatic adenocarcinoma, inflammatory diseases, Huntington’s Disease, and epigenetic regulation of gene expression. Projects requiring the enhanced MR imaging capabilities include high resolution studies of brain neural tissue microstructure, multimodal studies of brain neurovacular coupling and neurotransmitter receptor trafficking, cardiac fibrosis imaging, and Chemical Exchange Saturation Transfer (CEST) MRI studies of oncolytic virotherapy.

项目概要 需要资金来升级现有的 4.7 Tesla Bruker PET-MRI 控制台。拟议的 仪器将成为促进新型 PET 和 MR 分子成像发展的关键组成部分 造影剂以及用于大脑结构和神经通路连接的扩散 MRI 研究。 PET-MRI 扫描仪服务于 NIH 资助的大型用户社区，涵盖各种生物医学学科 包括纤维化、癌症、心脏病学、基因表达以及大脑结构和功能研究。我们目前 为麻省总医院/哈佛大学/麻省理工学院系统以及大波士顿/剑桥地区的用户提供服务 地区。 所请求的 MRI 控制台升级将取代即将结束的旧 Avance III Bruker 控制台。 它的使用寿命。从 2024 年开始，Bruker Biospin 将不再支持或维修 Avance III 控制台。到期的 到 MRI 控制台时代，过去几年我们发生了许多设备故障， 导致扫描仪显着停机。未来此类设备故障将很难解决，因为 布鲁克将不再库存备件或维修此类旧控制台。请求的控制台升级将 因此，让我们能够继续为 NIH 资助的当地大型用户社区提供服务，并提供重要的分子 成像和脑结构成像功能，为快速扩大的分子和大脑用户群提供服务 成像兴趣。 特别是，所提议的仪器将允许将 PET-MRI 工作流程与 PET 和 MRI 集成 在同一软件环境中获取数据，并进行无缝图像重建和配准。在 此外，改进的 3D 动态匀场、基于 EPI 的扩散序列以及梯度线圈性能 将极大地促进脑扩散MRI研究。需要 MR-PET 的项目包括开发 磁共振成像 (MRI) 和正电子发射断层扫描 (PET) 分子造影剂 肝纤维化、心脏纤维化、肺纤维化、转移性乳腺癌、胃癌、 胰腺癌、炎症性疾病、亨廷顿病和基因表观遗传调控 表达。需要增强 MR 成像能力的项目包括大脑的高分辨率研究 神经组织微观结构、脑神经血管耦合和神经递质受体的多模态研究 溶瘤的运输、心脏纤维化成像和化学交换饱和转移 (CEST) MRI 研究 病毒疗法。