Console Upgrade for 4.7T PET-MRI Preclinical Scanner

4.7T PET-MRI 临床前扫描仪控制台升级

• 批准号: 10630520
• 负责人: CHRISTIAN T FARRAR
• 金额: $ 60万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630520
• 关键词: 3-Dimensional; Address; Age; Boston; Brain; Brain imaging; Chemicals; Communities; Computer software; Contrast Media; Coupling; Data; Development; Diffusion; Diffusion Magnetic Resonance Imaging; Discipline; Disease; Environment; Equipment Failure; Fibrosis; Funding; Future; Gene Expression; Gene Expression Regulation; Hepatic Fibrogenesis; Huntington Disease; Image; Inflammatory; Magnetic Resonance Imaging; Malignant Neoplasms; Metastatic breast cancer; Neural Pathways; Neurotransmitter Receptor; Pancreatic Adenocarcinoma; Performance; Positron-Emission Tomography; Resolution; Services; Structure; System; Tissues; United States National Institutes of Health; base; coronary fibrosis; epigenetic regulation; image reconstruction; image registration; imaging capabilities; improved; instrument; interest; malignant stomach neoplasm; molecular imaging; multimodality; neural; novel; oncolytic virotherapy; pre-clinical; structural imaging; trafficking

Project Summary Funding is requested for an upgrade of an existing 4.7 Tesla Bruker PET-MRI console. The proposed instrument will be a crucial component in facilitating the development of novel PET and MR molecular imaging contrast agents and for diffusion MRI studies of brain structure and neural pathway connectivity. The PET-MRI scanner serves a large NIH-funded user community encompassing a wide variety of biomedical disciplines including fibrosis, cancer, cardialogy, gene expression, and brain structure and function studies. We currently serve users both within the MGH/Harvard/MIT system as well as from around the greater Boston/Cambridge region. The requested MRI console upgrade will replace an old Avance III Bruker console that is nearing the end of its usefull lifetime. Starting in 2024 Bruker Biospin will no longer support or service the Avance III console. Due to the age of the MRI console, we have had numerous equipment failures over the last few years which have caused significant scanner downtime. In the future, such equipment failures will be difficult to address since Bruker will no longer stock spare parts or service such old consoles. The requested console upgrade would therefore allow us to continue to serve the large local NIH-funded user community and offer important molecular imaging and brain structural imaging capabilities to the rapidly expanding user base with molecular and brain imaging interests. In particular, the proposed instrument would allow for integrated PET-MRI workflow with both PET and MRI data acquired in the same software environment with seemless image reconstruction and registration. In addition, the improved 3D dynamic shimming, EPI based diffusion sequences, and gradient coil performance will greatly enhance the brain diffusion MRI studies. Projects requiring MR-PET include the development of Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) contrast agents for molecular imaging of liver fibrogenesis, cardiac fibrosis, pulmnary fibrosis, metastatic breast cancer, gastric cancer, pancreatic adenocarcinoma, inflammatory diseases, Huntington’s Disease, and epigenetic regulation of gene expression. Projects requiring the enhanced MR imaging capabilities include high resolution studies of brain neural tissue microstructure, multimodal studies of brain neurovacular coupling and neurotransmitter receptor trafficking, cardiac fibrosis imaging, and Chemical Exchange Saturation Transfer (CEST) MRI studies of oncolytic virotherapy.

项目摘要 要求资金升级现有的4.7 Tesla Bruker Pet-MRI控制台。提议 仪器将是支持新型PET和MR分子成像的发展的关键组成部分 对比剂以及用于大脑结构和神经途径连通性的扩散MRI研究。宠物-MRI 扫描仪为NIH资助的大型用户社区提供服务，包括各种生物医学学科 包括纤维化，癌症，心脏病，基因表达以及大脑结构和功能研究。我们目前 在MGH/Harvard/MIT系统中以及大波士顿/剑桥市内为用户提供服务 地区。 请求的MRI控制台升级将取代旧的Avance III Bruker控制台，该控制台接近 它有用的一生。从2024年开始，Bruker Biospin将不再支持或为Avance III控制台提供服务。到期的 到MRI控制台的年龄，在过去的几年中，我们有许多设备故障 引起了巨大的扫描仪停机时间。将来，此类设备故障将很难解决，因为 布鲁克将不再存放备件或这样的旧控制台。请求的控制台升级将 因此，允许我们继续为本地NIH资助的大型用户社区提供服务，并提供重要的分子 成像和大脑结构成像功能，可以通过分子和大脑快速扩展的用户群 成像兴趣。 特别是，拟议的仪器将允许使用PET和MRI的PET-MRI工作流程 在同一软件环境中获取的数据，并具有似乎无图像的重建和注册。在 此外，改进的3D动态光滑，基于EPI的扩散序列和梯度线圈性能 将大大增强大脑扩散MRI研究。需要MR-PET的项目包括开发 分子的磁共振成像（MRI）和正电子发射断层扫描（PET）对比剂 肝纤维发生，心脏纤维化，肺纤维化，转移性乳腺癌，胃癌的成像 胰腺腺癌，炎症性疾病，亨廷顿氏病和基因表观遗传调节 表达。需要增强MR成像功能的项目包括大脑的高分辨率研究 神经组织微观结构，脑神经循环偶联和神经递质接收器的多模式研究 贩运，心脏纤维化成像和化学交换饱和转移（CEST）MRI研究 病毒疗法。