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Novel Biofilm Paradigm Explaining Clinical Implant-Associated Illness.

解释临床植入相关疾病的新型生物膜范式。

基本信息

批准号：
10629428
负责人：
Mithun Sinha
金额：
$ 19.81万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-26 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10629428
关键词：
Address Adherence Adhesions Adipose tissue American Animal Model Autoimmune Autoimmune Responses Autoimmunity Bacteria Biological Biological Specimen Banks Breast CD4 Positive T Lymphocytes Chronic Clinical Collagen Connective Tissue Diseases Cosmetics Data Dental Implants Dioxygen Elective Surgical Procedures Exhibits Failure Fatigue Fatty Acids Foreign Bodies Future Growth Hip region structure Home Immune Immune response Immunologist Implant Infection Inflammation Inflammatory Response Internal Breast Prosthesis Investigation Knee Laboratories Life Expectancy Link Lipids Mammaplasty Mastectomy Mediating Medical Device Metals Microbial Biofilms Mus Myalgia National Institute of Allergy and Infectious Disease Octadecenoic Acids Operative Surgical Procedures Orthopedics Patients Persons Plastic Surgeon Prevalence Quality of life Reaction Replacement Arthroplasty Reporter Reporting Research Personnel Role Sampling Second Look Surgery Silicones Site Sterility Surface Surgeon Symptoms Syndrome Testing Texture Th1 Cells Tissues United States United States Food and Drug Administration United States National Institutes of Health Woman Work aging population animal data capsule enzyme activity experience gender affirmation hip replacement arthroplasty host microbiota immune activation immunogenic immunoreaction implant material implantable device improved mobility knee replacement arthroplasty malignant breast neoplasm medical implant novel oxidation oxidized lipid pathogenic bacteria prophylactic mastectomy prospective reconstruction response transcription factor

项目摘要

PROJECT SUMMARY This is a proposal from an investigator to address the mechanistic underpinnings of host-biofilm interaction in the context of surgical implant-associated complications. It is estimated 10 million women worldwide, including 3 million Americans have breast implants. Over 7 million Americans are living with hip/knee implants. Nearly 300,000 women annually have breast implant surgery in the United States, for reasons including post- mastectomy breast reconstruction (breast cancer and prophylactic mastectomy), revision of prior augmentation/ reconstruction, cosmetic augmentation, and gender affirmation. Over 1 million total hip and total knee replacement surgeries are performed each year in the US. With an aging population, there is a demand for improved mobility and quality of life. The number of joint replacement surgeries are projected to increase considerably in the future. Total joint replacement surgery is expected to continue to be one of the most common elective surgical procedures in the coming decades. There has been increased identification of patients experiencing a constellation of symptoms related to their implants. The symptoms described include myalgias, chronic fatigue, connective-tissue disorders, and a host of other manifestations often associated with autoimmune illnesses. Metal/plastic implants for arthroplasty and silicone implants for breasts are made of different materials. Thus, the underlying cause of these conditions may be associated with factors other than the implant material. Bacterial biofilms are one of the leading causes of surgical implant failures, infection and revision surgeries. Despite efforts to maintain sterility during surgery, implantable medical devices can become contaminated with the opportunistic bacteria from the host microflora many of which can form biofilm. This proposal aims to investigate the role of bacterial biofilms in the implant-associated illness. Host-biofilm interactions are guided by the local micro-environmental niche of host in which the biofilm reside. Breast and hip joint replacements have a host-microenvironment rich in adipose tissue comprising lipids. The proposal aims to study lipid metabolites (oxylipins) formed during biofilm-host interaction. Oxylipins are oxidized lipids formed from fatty acids by reactions involving dioxygen-dependent oxidation. Oxylipins have been reported to contribute to inflammatory response. We hypothesize that oxylipins formed due to biofilm can stimulate CD4+ T cell leading to autoimmune-like syndromes.

项目总结