Mechanistic studies of sickness sleep
病态睡眠的机制研究
基本信息
- 批准号:10630175
- 负责人:
- 金额:$ 40.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-15 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAdultAffectAfferent NeuronsAnimalsAuxinsBehaviorBehavior ControlBehavioralBiologicalBiological ModelsCaenorhabditis elegansCellsCellular StressChemicalsChronicClinical TreatmentDataDefectDiagnosticDrowsinessEpidermal Growth FactorEpidermal Growth Factor ReceptorFishesFunctional disorderFutureGenesGeneticGenetic TranscriptionGoalsHeat-Shock ResponseHumanImpairmentInfectionInflammatoryInvertebratesMammalsMethodsMotivationMovementMusMutagenesisMutagensMutateMutationNematodaNeuronsNeurosecretory SystemsPeptidesPeripheralPositioning AttributeReceptor SignalingRecoveryRegulationSignal TransductionSignaling MoleculeSiteSleepSleep DeprivationSourceStreamStressSymptomsSystemTestingTimeTranslatingUltraviolet RaysUncertaintyVertebratesViralVirus DiseasesWithdrawalarmcandidate identificationcytokinedeprivationenvironmental stressorfeedingflygene functiongene productgenetic manipulationgenome-wideinterestmortalitymutantparacrinepreventprogramssleep behaviorsocialtoolwhole genome
项目摘要
Project Summary
In the nematode C. elegans as in other animals, sickness is associated with reduced movement, reduced
feeding, and increased sleep. Sickness behavior in worms is induced by environmental stressors including
heat shock, ultraviolet light, and infection. This behavioral program during sickness is regulated by worm
central neurons that are activated by the cytokine epidermal growth factor (EGF). EGF causes reduced activity
in worms, flies, fish, and mice, but the mechanisms of EGF activation itself during sickness are not clear. We
will use C. elegans to study the mechanism of EGF regulation during sickness. In Aim 1, we will determine
where (from which cells) and when EGF is released to promote sickness behavior. To identify other regulators
of EGF activation, in Aim 2, we will perform genome-wide discovery screens for genes required for sickness
behavior. In Aim 3, we will test the hypothesis that sickness behavior supports survival during sickness. A long-
term goal of these studies is to identify candidate signaling molecules for developing diagnostics and
treatments of sleepiness during sickness and to understand the importance of sleep in promoting recovery
from illness.
项目摘要
在线虫中,和其他动物一样,疾病与运动减少、减少
进食,增加睡眠。蠕虫的疾病行为是由环境应激源引起的,包括
中暑、紫外线和感染。疾病期间的这种行为程序是由蠕虫调节的
由细胞因子表皮生长因子(EGF)激活的中枢神经元。EGF导致活动减少
在蠕虫、苍蝇、鱼和老鼠中,EGF被激活,但疾病过程中EGF自身激活的机制尚不清楚。我们
将利用线虫研究EGF在疾病过程中的调节机制。在目标1中,我们将确定
在哪里(从哪个细胞)以及何时释放EGF来促进疾病行为。确定其他监管机构
在目标2中,我们将对疾病所需的基因进行全基因组的发现筛选
行为。在目标3中,我们将检验疾病行为支持疾病期间存活的假设。一个很长的-
这些研究的术语目标是确定用于开发诊断和诊断的候选信号分子
疾病期间嗜睡的治疗以及了解睡眠在促进康复中的重要性
因为生病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David Menassah Raizen其他文献
David Menassah Raizen的其他文献
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{{ truncateString('David Menassah Raizen', 18)}}的其他基金
Neuropeptidergic regulation of sleep in C. elegans
线虫睡眠的神经肽调节
- 批准号:
8884123 - 财政年份:2015
- 资助金额:
$ 40.63万 - 项目类别:
Neuropeptidergic regulation of sleep in C. elegans
线虫睡眠的神经肽调节
- 批准号:
9011550 - 财政年份:2015
- 资助金额:
$ 40.63万 - 项目类别:
Neuropeptidergic regulation of sleep in C. elegans
线虫睡眠的神经肽调节
- 批准号:
9312998 - 财政年份:2015
- 资助金额:
$ 40.63万 - 项目类别:
Regulation of sleep-like behavior in C. elegans
秀丽隐杆线虫类睡眠行为的调节
- 批准号:
8013506 - 财政年份:2009
- 资助金额:
$ 40.63万 - 项目类别:
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