TR&D 1 - Generating Differential and Dynamic Networks
TR
基本信息
- 批准号:10629204
- 负责人:
- 金额:$ 34.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-13 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AdoptionAutomobile DrivingBiologicalBiologyCell modelCellsCellular biologyClinicalComplexDataDatabasesDevelopmentDiseaseDrug CombinationsEcosystemEngineeringFractionationGenesGenetic TranscriptionGenomicsGoalsHumanIndividualMachine LearningMapsMass Spectrum AnalysisMeasurementMeasuresMethodsModelingMolecularNetwork-basedNormal tissue morphologyOntologyOrganismPathway AnalysisPathway interactionsPharmaceutical PreparationsPhosphorylationPositioning AttributeProtein Interaction MappingProteinsProteomicsRegenerative MedicineResolutionResourcesSamplingSpeedTechniquesTechnologyTimeTissuesVisualizationWorkbiological systemscancer therapycell typecombinatorialcostdata portaldesigngene functionnetwork modelsnew technologynovelpredictive modelingprogramsprotein expressionresponsesingle-cell RNA sequencingtechnology research and developmenttissue repairtool
项目摘要
TR&D 1: GENERATING DIFFERENTIAL AND DYNAMIC NETWORKS – PROJECT SUMMARY
Biological systems are incredibly diverse and dynamic, with hundreds of known cell types and states in a
complex multicellular organism such as human. In contrast, molecular network and pathway maps typically
show a single static view of all interactions for an organism, largely because of cost and technical limitations of
gene and protein interaction mapping technologies. Recently, a range of breakthrough experimental advances
is enabling networks to be mapped at much higher coverage and finer resolution in space and time than
previously possible. New mass spectrometry technology can capture comprehensive changes in protein
expression and phosphorylation at lower cost and higher speed, enabling measurement of differential network
expression information in clinical samples and other contexts. Single-cell genomics, including single-cell
RNA-seq (scRNA-seq), now achieves high resolution measurements of transcriptional state on a per cell basis
over multiple time points. Finally, new high-resolution mass spectrometry workflows enable comprehensive
interactome mapping in a sample at multiple time points and with spatial resolution across a tissue or within
different cellular compartments.
In this TR&D, we develop new computational technologies that take advantage of these qualitatively new data
types to better understand and quantitatively model how networks function in differential biological conditions
and to infer whole-cell dynamic network models. The goals of these technologies are to [Aim 1] capture the
molecular information flow from targeted perturbations to downstream cellular responses in fully data-driven
predictive dynamic network models; [Aim 2] functionally characterize mechanisms defining individual cell types
and model the dynamics of developmental lineages; and [Aim 3] visualize, analyze and predictively model
differential changes in protein interactions across biological contexts, such as disease versus normal. Our
technology research and development aims are motivated by a range of Driving Biomedical Projects (DBPs),
including global mapping of protein interactions (DBPs 1-2,5) and single cell biology focused on understanding
tissue development with engineering applications in regenerative medicine (DBPs 6,7). These aims will be
supported by Technology Partnerships that will help us use gene function information from biological
ontologies and databases (TPs 1,3) and scRNA-seq data portals (TP 5) to characterize differential and
dynamic networks of cells, tissues and disease states.
研究与开发1:生成微分和动态网络-项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CHRIS SANDER其他文献
CHRIS SANDER的其他文献
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{{ truncateString('CHRIS SANDER', 18)}}的其他基金
Accelerated Determination of 3D Structures of Proteins and Complexes
加速测定蛋白质和复合物的 3D 结构
- 批准号:
9059732 - 财政年份:2013
- 资助金额:
$ 34.01万 - 项目类别:
Accelerated Determination of 3D Structures of Proteins and Complexes
加速测定蛋白质和复合物的 3D 结构
- 批准号:
8483934 - 财政年份:2013
- 资助金额:
$ 34.01万 - 项目类别:
Accelerated Determination of 3D Structures of Proteins and Complexes
加速测定蛋白质和复合物的 3D 结构
- 批准号:
8840975 - 财政年份:2013
- 资助金额:
$ 34.01万 - 项目类别:
Pathway Commons: A Public Library of Biological Pathways
Pathway Commons:生物途径公共图书馆
- 批准号:
8549293 - 财政年份:2012
- 资助金额:
$ 34.01万 - 项目类别:
Pathway Commons: A Public Library of Biological Pathways
Pathway Commons:生物途径公共图书馆
- 批准号:
8243036 - 财政年份:2012
- 资助金额:
$ 34.01万 - 项目类别:
Pathway Commons: Research Resource for Biological Pathways
Pathway Commons:生物途径研究资源
- 批准号:
8935277 - 财政年份:2012
- 资助金额:
$ 34.01万 - 项目类别:
Pathway Commons: A Public Library of Biological Pathways
Pathway Commons:生物途径公共图书馆
- 批准号:
8698796 - 财政年份:2012
- 资助金额:
$ 34.01万 - 项目类别:
Pathway Commons: Research Resource for Biological Pathways
Pathway Commons:生物途径研究资源
- 批准号:
9357629 - 财政年份:2012
- 资助金额:
$ 34.01万 - 项目类别:
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