Pre-clinical Bruker Albira Si PET/SPECT/CT imaging system

临床前 Bruker Albira Si PET/SPECT/CT 成像系统

基本信息

  • 批准号:
    10633022
  • 负责人:
  • 金额:
    $ 108.43万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-26 至 2024-09-25
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT The Department of Radiology at the Stanford School of Medicine is a preeminent institution renown for developing next generation imaging technology, molecular imaging, in vitro diagnostics, image-guided therapeutics, and informatics for precision health. Our Molecular Imaging Program at Stanford (MIPS), a highly regarded interdisciplinary research division established in 2003, brings together scientists and physicians who share a common interest in developing and using state-of-the-art imaging technology and developing molecular imaging assays for studying intact biological systems. There is now a pressing unmet programmatic need for a multimodal small animal imaging system that offers state-of-the-art imaging available in the Bruker Albira Si PET/SPECT/CT. It will be an enabling technology at Stanford, creating new research opportunities for multi- tracer imaging, significantly broadening our repertoire of radionuclides beyond positron-emitters and accelerating novel radiopharmaceutical development and clinical translation in our theragnostics program. It will allow sunsetting of our once-state-of-the-art, but now end-of-life workhorse Inveon PET/CT, which has experienced increasing downtime due to failures. It will be placed in our comprehensive small animal imaging facility as a Stanford shared resource and supported by a team of PhD-level senior scientists. An integrated trimodal imaging system will immediately contribute to our well-established and growing radionuclide-based biomarker discovery program in diagnostics and radioligand therapy. The Major and Minor users we have assembled reflect junior through senior faculty with NIH-funded research projects and includes highly accomplished experts in their fields. They are particularly interested in multi-tracer applications and, therefore, an integrated system combining SPECT, PET and CT is especially needed. The nuclear imaging modalities would support our researchers who study image-guided drug delivery, cancer biology, neurological diseases, cancer cell and gene therapies, and immunity and immunotherapy, in addition to developing novel diagnostic and theragnostic radiopharmaceuticals and imaging strategies. SPECT is essential for researchers who need access to biomarkers outside of those for PET and for imaging more than one target concurrently. Both modalities, when combined with anatomical CT, are essential to advance novel radiopharmaceuticals from discovery to first-in-human clinical translation, and will be central to our expanding theragnostics activities. The addition of this instrument will converge with programmatic activities at Stanford: new state-of-the-art cyclotron and radiochemistry facility, first designated comprehensive Radiopharmaceutical Therapy Center of Excellence, growing interest in theragnostics and biomarker discovery, and new educational opportunities in biomedical physics, imaging and radionuclide-based therapy. The Albira system will create novel opportunities in small animal research and synergize with Stanford’s long-range vision to lead in biomedical innovation and advanced precision medicine.
项目总结/摘要 斯坦福大学医学院的放射科是一个杰出的机构, 开发下一代成像技术,分子成像,体外诊断,图像引导 治疗学和精准健康信息学。我们在斯坦福大学(MIPS)的分子成像项目, 被视为跨学科研究部门成立于2003年,汇集了科学家和医生谁 在开发和使用最先进的成像技术和开发分子生物学方面有着共同的兴趣, 用于研究完整生物系统的成像分析。目前迫切需要一个未得到满足的方案, 多模式小动物成像系统,提供Bruker Albira Si中最先进的成像 PET/SPECT/CT。这将是斯坦福大学的一项使能技术,为多学科创造新的研究机会。 示踪剂成像,大大拓宽了我们的放射性核素的库,超越了正电子发射体, 新的放射性药物开发和临床翻译在我们的治疗不确定性计划。它将允许 我们曾经的最先进的,但现在结束了生命的主力Inveon PET/CT的日落,它经历了 由于故障而增加停机时间。它将被放置在我们的综合小动物成像设施, 斯坦福大学共享资源,并由博士级资深科学家团队提供支持。集成的三峰成像 该系统将立即有助于我们完善和不断增长的基于放射性核素的生物标志物的发现 诊断学和放射性配体疗法的研究计划。我们收集的主要和次要用户反映了初级用户 通过高级教师与NIH资助的研究项目,包括在各自领域的高度成就的专家。 他们特别感兴趣的是多示踪剂的应用,因此,一个综合系统结合 尤其需要SPECT、PET和CT。核成像模式将支持我们的研究人员, 研究图像引导药物输送,癌症生物学,神经系统疾病,癌细胞和基因治疗,以及 免疫和免疫治疗,除了开发新的诊断和治疗不可知放射性药物 和成像策略。SPECT对于那些需要获得生物标志物以外的生物标志物的研究人员来说是必不可少的。 PET和用于同时成像多于一个目标。这两种模式,当与解剖CT结合时, 对于推进新型放射性药物从发现到首次人体临床转化至关重要, 对我们不断扩大的治疗不可知论活动至关重要增加这一工具将与 斯坦福大学的方案活动:新的最先进的回旋加速器和放射化学设施,首次指定 全面的放射性药物治疗卓越中心,对治疗不确定性的兴趣日益增长, 生物标志物的发现,以及生物医学物理学,成像和放射性核素为基础的新的教育机会 疗法Albira系统将为小动物研究创造新的机会,并与斯坦福大学的 长远的愿景是引领生物医学创新和先进的精准医疗。

项目成果

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Jason Thanh Lee其他文献

Jason Thanh Lee的其他文献

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{{ truncateString('Jason Thanh Lee', 18)}}的其他基金

Cancer Imaging
癌症影像
  • 批准号:
    10411094
  • 财政年份:
    2007
  • 资助金额:
    $ 108.43万
  • 项目类别:
Cancer Imaging
癌症影像
  • 批准号:
    10626977
  • 财政年份:
    2007
  • 资助金额:
    $ 108.43万
  • 项目类别:

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