Climate factors, racial/ethnic disparities, and menstrual cycle health

气候因素、种族/民族差异和月经周期健康

• 批准号: 10633874
• 负责人: Shruthi Mahalingaiah
• 金额: $ 58.2万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633874
• 关键词: 15 year old; Acceleration; Acne; Address; Adult; Affect; Age; Air Pollutants; Air Pollution; Biological; Biological Factors; Birth; Black race; Boston; Censuses; Cessation of life; Characteristics; Childhood; Chronic; Cities; Climate; Clinical; Code; Cohort Studies; Collection; Counseling; DNA Repair; Data; Data Set; Daughter; Diabetes Mellitus; Diagnostic; Disease; Disparity; Dyslipidemias; Electronic Health Record; Embryo; Endocrine disruption; Enrollment; Environment; Environmental Exposure; Environmental Impact; Environmental Risk Factor; Exposure to; Fertilization in Vitro; Goals; Growth; Health; Health Promotion; Heart Diseases; Hirsutism; Hispanic; Home; Hormones; Hospitals; Humidity; Hypertension; Hypothalamic structure; Impairment; Infertility; Inflammation; Irregular Menstruation; Knowledge; Length; Life Cycle Stages; Literature; Longevity; Mammals; Medical center; Menarche; Menstrual cycle; Menstruation; Metabolic syndrome; Minority; Monitor; Nurses; Nurses' Health Study; Obesity; Outcome; Ovarian Diseases; Ovary; Oxidative Stress; Participant; Physiological; Pituitary Gland; Polycystic Ovary Syndrome; Population; Pregnancy; Pregnancy loss; Race; Recording of previous events; Reporting; Reproductive Health; Risk; Risk Reduction; School-Age Population; Seminal fluid; Temperature; Testing; Time; Toxic effect; United States; Variant; Woman; androgen excess; burden of illness; climate-related exposures; cohort; ethnic disparity; ethnic diversity; girls; high school; hormonal signals; male; offspring; ovarian dysfunction; premature; prenatal; prenatal exposure; prospective; racial disparity; reproductive; reproductive function; reproductive outcome; safety net; success; telomere; time-to-pregnancy

PROJECT SUMMARY The menstrual cycle is a marker of physiologic and reproductive health and is tightly controlled by hormone signals between the hypothalamus, pituitary, and ovaries. The menstrual cycle can be disrupted by environmental and biological factors that cause hormone dysregulation and ovarian dysfunction. The most common cause of irregular menses in reproductive-age women is polycystic ovary syndrome (PCOS); hallmark features include ovarian dysfunction and androgen excess. Women with PCOS also have an increased risk of developing diabetes, heart disease, obesity, dyslipidemia across their lifespan. Climate factors, such as temperature, have been shown to affect reproductive function in mammals. Air pollution (AP) exposure has been associated with accelerated time to pregnancy loss, arrested embryonic growth in the culture environment, and reduced success of in vitro fertilization. Life course exposures have differing potential biological mechanisms. Gestational AP exposure has been reported to reduce telomere length at birth. Assessment of AP exposures and MCC are limited by studies of heterogenous populations with limited racial/ethnic diversity, incomplete city-level census tract level monitoring, retrospective collection of cycle history, and lack of MCC and PCOS ascertainment11, 12. We will additionally evaluate life course exposure to climate factors including temperature and humidity to understand their contribution to MCC outcomes and risk for PCOS. We will evaluate cumulative lifetime exposure and life course exposure to AP during the sensitive time windows of (1) gestation, (2) childhood/premenarche, and (3) adulthood to determine whether prenatal or adult exposures confer greatest risk. We will additionally evaluate disparities in AP exposures and MCC outcomes in a SafetyNet hospital population.

项目摘要 月经周期是生理和生殖健康的标志，受激素的严格控制。 下丘脑垂体和卵巢之间的信号。月经周期可能会被以下因素打乱： 环境和生物因素导致激素失调和卵巢功能障碍。最 多囊卵巢综合征（PCOS）是导致育龄妇女月经不调的常见原因。 特征包括卵巢功能障碍和雄激素过多。患有PCOS的女性也有增加的风险， 糖尿病、心脏病、肥胖症、血脂异常。 气候因素，如温度，已被证明会影响哺乳动物的生殖功能。空气 污染（AP）暴露与加速妊娠丢失，胚胎发育停滞， 在培养环境中生长，并降低体外受精的成功率。生命过程中的暴露 不同的潜在生物机制。据报道，Geodiazepam AP暴露会减少端粒 出生时的长度AP暴露和MCC的评估受到异质性人群研究的限制， 有限的种族/民族多样性，不完整的城市一级人口普查区一级的监测， 周期史，以及缺乏MCC和PCOS的确定11，12。我们将额外评估生命历程 暴露于气候因素，包括温度和湿度，以了解其对MCC的贡献 PCOS的风险和后果。 我们将评估在敏感时间内AP的累积终生暴露和生命过程暴露 （1）妊娠期，（2）儿童期/初潮前，和（3）成年期的窗口，以确定是否产前或成年 暴露会带来最大的风险。我们还将评估AP暴露和MCC结局的差异， a SafetyNet医院人口。