Evaluation of an OMV-adjuvanted Chimeritrope Vaccine against Lyme Disease
Evaluation of an OMV-adjuvanted Chimeritrope Vaccine against Lyme Disease
批准号:
10672571
负责人:
LISA MORICI
金额:
$127.5万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-30 至 2023-09-29
关键词:
AdjuvantAntigensAttenuatedBiteBorrelia burgdorferiBurkholderiaContractorDoseEtiologyEvaluationFormulationHumanIxodesLipid ALyme DiseaseLyme Disease VaccinesMembraneMusPreparationResearchSafetyScheduleTestingVaccine AdjuvantVaccinesVesicleefficacy evaluationefficacy studyimmunogenicitynonhuman primatepreventscreeningunvaccinated
中文摘要
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英文摘要
The Contractor is developing Burkholderia-derived outer membrane vesicles (OMVs), containing a naturally-attenuated lipid A, as a vaccine adjuvant. This research will develop the adjuvant within the context of a vaccine to prevent Lyme disease in humans. Borrelia burgdorferi is the etiologic agent of Lyme disease, which is transmitted by the bite of Ixodes ticks. There are no currently approved vaccines that prevent Lyme disease in humans.
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会议论文
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项目类别:
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资助金额:$170.97万
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财政年份:2018
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负责人:LISA MORICI
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依托单位:
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项目类别:
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依托单位:
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批准号:2022J011295
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项目类别:省市级项目
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资助金额:10.0万元
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批准年份:2022
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批准年份:2008
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依托单位: