Biased Mu-Opioid Receptor Analgesics to Prevent Overdose and Opioid Use Disorders

美国约有1亿人患有疼痛，其中约900万至1200万人患有 1由于阿片类药物仍处于治疗的最前沿，很明显，阿片类药物滥用 和阿片类药物过量已经成为重大和复杂的公共卫生挑战。阿片类药物过量是 这是美国意外死亡的主要原因，估计每天有100人死于阿片类药物过量， 2虽然多种因素无疑是使用和滥用 阿片类药物，迫切需要一种有效的阿片类镇痛药，也解决了周围的重大问题， 阿片类药物滥用和过量死亡。我们对相关药理学机制的理解进展 与G蛋白偶联受体的信号传导的关系已经导致了μ阿片受体的激活 (MOR)介导治疗和副作用，并通过不同的信号传导 途径。与吗啡和其它莫尔激动剂相关的副作用已通过以下途径追溯到作用： β-抑制蛋白途径，而镇痛与G-蛋白途径有关。G蛋白特异性激动剂，避免激活 β-arrestin信号及其相关的负性后果为通路的发展提供了新的策略 特定的或“偏向”的药物，旨在选择性地产生镇痛作用，同时消除不必要的副作用，包括 呼吸抑制滥用倾向和便秘 Mebias Discovery，Inc.已经开发了一种新的平台，并确定了有效的高度“偏倚”的莫尔激动剂， 镇痛剂，但没有阿片样物质诱导的副作用。Mebias对其IND候选药物MEB-1170的临床前研究 在3种疼痛模型中显示出有效性，而没有已知的阿片样物质副作用（呼吸抑制，镇痛耐受， 镇静、便秘）。此外，MEB-1170在滥用责任模型中显示出希望 （自我管理，药物歧视，条件位置偏好，退出）表明它可能是一个游戏规则改变者， 一种非成瘾性镇痛药，用于替代II类阿片类药物治疗疼痛。 补充资金申请将用于帮助支付IND使能研究的成本超支，详见我们的 预算理由。 1 Califf，Robert M.，珍妮特·伍德考克和斯蒂芬·奥斯特罗夫“对处方阿片类药物滥用的积极反应。“新 England Journal of Medicine 374，no.15（2016）：1480-1485. 2“鸦片过量。“疾病控制和预防中心。2017年8月30日。2018年1月12日访问。 https://www.cdc.gov/drugoverdose/epidemic/index.html

Approximately 100 million people in the United States suffer from pain with some 9 to 12 million individuals suffering from chronic or persistent pain.1 With opioids remaining at the forefront of treatment, it has become clear that opioid abuse and opioid overdose have emerged as significant and complicated public health challenges. Drug overdose from opioids is the leading cause of accidental death in the U.S. with an estimated 100 individuals a day dying from opioid overdose due to respiratory depression.2 Although multiple factors are unquestionably responsible for the increase in the use and abuse of opioids, there is a pressing need for an effective opioid analgesic that also addresses the significant issues surrounding opioid abuse liability and overdose fatalities. Advances in our understanding of the pharmacological mechanisms associated with signaling of G-protein coupled receptors have resulted in the knowledge that activation of the mu-opioid receptor (MOR) mediates both the therapeutic and adverse effects and does so through pharmacologically distinct signaling pathways. The adverse effects associated with morphine and other MOR agonists have been traced to action through the β-arrestin pathway, while analgesia is tied to the G-protein pathway. G-protein specific agonists that avoid activation of β-arrestin signaling and its associated negative consequences provide novel strategies for the development of pathway specific or ‘biased’ drugs designed to selectively produce analgesia while eliminating unwanted adverse effects that include respiratory depression, abuse liability, and constipation. Mebias Discovery, Inc. has developed a novel platform and has identified highly ‘biased’ MOR agonists that are effective analgesics but are devoid of opioid induced adverse effects. Mebias’ preclinical studies of its IND candidate MEB-1170 has shown efficacy in 3 pain models without the known opioid adverse effects (respiratory depression, tolerance to analgesia, sedation, constipation) shown by marketed MOR drugs. In addition, MEB-1170 shows promise in abuse liability models (self-administration, drug discrimination, condition place preference, withdrawal) suggesting it could be a game changer as a non-addictive analgesic to replace Scheduled II opioids in pain management. The Supplemental Funding request will be utilized to help cover cost overruns of IND enabling studies as detailed in our Budget Justification. 1 Califf, Robert M., Janet Woodcock, and Stephen Ostroff." A proactive response to prescription opioid abuse." New England Journal of Medicine 374, no.15 (2016): 1480-1485. 2 "Opioid overdose." Centers for Disease Control and Prevention. August 30, 2017. Accessed January 12, 2018. https://www.cdc.gov/drugoverdose/epidemic/index.html