CAMKV 假激酶的生化特征-猫眼课题宝

CAMKV 假激酶的生化特征

批准号：

10666873

负责人：

Stefan W. Vetter

金额：

$14.5万

依托单位：

NORTH DAKOTA STATE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2023

资助国家：

美国

项目状态：

未结题

起止时间：

2023-06-01 至 2025-05-31

来源：

https://reporter.nih.gov/project-details/10666873

关键词：

Affinity Amino Acids Antibodies Binding Binding Proteins Binding Sites Biochemical Biological Biological Assay Brain C-terminal Calmodulin Calorimetry Catalytic Domain Central Nervous System Data Development Disease Enzymes Foundations Gene Expression Genes Homologous Gene Human Immobilization Ions Knowledge Learning Length Libraries Ligand Binding Ligands Link Mass Spectrum Analysis Measures Memory Mental disorders Methods Molecular Molecular Conformation Mutation Neurons Nucleotides Pathologic Phosphotransferases Physiological Pilot Projects Play Post-Traumatic Stress Disorders Property Proteins Proteomics Psyche structure Publications Rattus Recombinants Regulation Research Role Signal Transduction Source Tail Thermodynamics Tissues Titrations Transition Temperature United States National Institutes of Health Vesicle brain tissue cell growth regulation cognitive function drug-like compound experimental study genome wide association study human disease inhibitor innovation insight interest kinase inhibitor preservation protein complex protein protein interaction scaffold

中文摘要

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英文摘要

CAMKV is a brain specific pseudokinase and closely related to calmodulin regulated kinase 1 (CAMK1). Gene expression studies and genome wide association studies suggest a possible role of CAMKV in mental disorders, including post-traumatic stress disorder. CAMKV has been identified by the NIH – IDG initiative as a protein in need for additional research. The proposed research will contribute to the biochemical characterization of CAMKV by investigating its mechanism of regulation on the molecular level. In specific aim 1, ligands targeting the degenerated ATP binding pocket of CAMKV will be identified. Expected results, will provide insights in the cellular regulation of CAMKV by endogenous ligands and also identify small-drug like molecules as potential CAMKV inhibitors or activators. In specific aim 2, CAMKV interacting proteins will be isolated from brain tissue. Knowledge of CAMKV targets will be critically important to understand its role in normal neuronal tissue, as well as to provide a foundation for the role of CAMKV in mental diseases.

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海外基金

Biochemical Characterization of the CAMKV Pseudokinase

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