The Role of 17β-Estradiol in Delirium

17β-雌二醇在谵妄中的作用

基本信息

  • 批准号:
    10667233
  • 负责人:
  • 金额:
    $ 20.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-04-01 至 2025-03-31
  • 项目状态:
    未结题

项目摘要

ABSTRACT Delirium is frequently precipitated by urinary tract infection (UTI), a condition that disproportionately affects older women and contributes to increased mortality, prolonged length of stay, and accelerated long-term cognitive decline. Existing treatments for delirium center largely on treatment of the precipitating cause, modification of environmental contributors, and avoidance of deliriogenic medications; however, do not address the underlying pathobiology of the condition. We have developed a novel mouse model of UTI-induced delirium and generated compelling preliminary data that demonstrate a potential role for exogenously administered 17β-estradiol in mitigating UTI-induced delirium. These findings may explain, at least in part, why older women, who after menopause have reduced levels of 17β-estradiol, are particularly susceptible to developing delirium. In this R21 application, we propose to use our novel mouse model of urinary tract infection- induced delirium, oophorectomized mice, state-of-the-art behavioral testing, and genetically modified mice to determine whether 17β-estradiol ameliorates the structural and functional phenotypes of delirium via the G protein-coupled estrogen receptor 1. Given the lack of evidence-based pharmacological treatments for delirium, the findings from this research could have widespread clinical implications, including providing novel pre-clinical justification for clinical trials using a short-term application of an existing drug, 17β-estradiol, to ameliorate UTI- induced delirium and quality of life for millions of older women around the world.
摘要

项目成果

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Shouri Lahiri其他文献

Shouri Lahiri的其他文献

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{{ truncateString('Shouri Lahiri', 18)}}的其他基金

Neuropathology of Cognitive Impairment in Critical Illness
危重疾病认知障碍的神经病理学
  • 批准号:
    9810539
  • 财政年份:
    2019
  • 资助金额:
    $ 20.88万
  • 项目类别:

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