CRCNS: Deconstructing dynamics of motor cortex in freely moving behavior
CRCNS:解构自由运动行为中运动皮层的动力学
基本信息
- 批准号:10666693
- 负责人:
- 金额:$ 40万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-15 至 2027-04-30
- 项目状态:未结题
- 来源:
- 关键词:BehaviorBehavioralBrainCentral Nervous SystemDataDevelopmentDimensionsElectrodesImageIndividualInstructionInvestigationLabelModelingMotorMotor CortexMovementNeurosciencesOrganPersonsRecoveryRunningStrokeSystemTechniquesTechnologyWalkingWorkbrain machine interfacecomputational neurosciencecomputerized toolsdisabilityfree behaviorinnovationinsightinterestmind controlmotor behaviormotor disorderneuralneural modelneuromechanismnoveloperationskills
项目摘要
PROJECT SUMMARY (See instructions):
What operations are performed by the mammalian central nervous systems to coordinate and conduct
voluntary movement? Motor systems neuroscience seeks to understand these neural mechanisms. The
last two decades have witnessed a transformation in this field with the use of multielectrode recordings
and statistical estimation and modeling techniques. These technological advances have yielded rich,
low-dimensional neural dynamics that are suggestive of the mechanisms underlying behavior. To
minimize confounds, the overwhelming majority of these studies utilize behavioral constraint to isolate just
the behaviors of interest for study. While effective for generating many behaviorally similar trials, this may
have the unintentional consequence of artificially constraining neural dynamics to a subset of its full
range.
This project seeks to better understand the full repertoire of behavior in a freely-moving setting and model
this neural activity using novel computational tools. This project combines the expertise of two
neuroscientists with complemenary skillsets spanning systems and computational neuroscience. This
project will involve acquiring novel, freely-moving data using the recent advances in depth imaging
cameras and modeling the dynamics of the labelled neural data with innovative switching dynamical
models.
TThis combined expertise will be applied to the investigation of the initiation vs sustaining of movement,
the decomposition of walking periods into distinct dynamical regimes, and an analysis of foraging
behavior.
Taken together, these studies will further our understanding of how neural dynamics drive unconstrained
motor behavior. This insight has implications for the development of ambulatory brain-machine interfaces
and may inform the treatment of individuals with motor disorders such as stroke.
项目概述(见说明):
项目成果
期刊论文数量(0)
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Scott Warren Linderman其他文献
Scott Warren Linderman的其他文献
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{{ truncateString('Scott Warren Linderman', 18)}}的其他基金
Unified, Scalable, and Reproducible Neurostatistical Software
统一、可扩展且可重复的神经统计软件
- 批准号:
10725500 - 财政年份:2023
- 资助金额:
$ 40万 - 项目类别:
CRCNS: Deconstructing dynamics of motor cortex in freely moving behavior
CRCNS:解构自由运动行为中运动皮层的动力学
- 批准号:
10610495 - 财政年份:2022
- 资助金额:
$ 40万 - 项目类别:
Neural representation of mating partners by male C. elegans
雄性线虫对交配伙伴的神经表征
- 批准号:
10457866 - 财政年份:2019
- 资助金额:
$ 40万 - 项目类别:
Neural representation of mating partners by male C. elegans
雄性线虫对交配伙伴的神经表征
- 批准号:
10685522 - 财政年份:2019
- 资助金额:
$ 40万 - 项目类别:
Neural representation of mating partners by male C. elegans
雄性线虫对交配伙伴的神经表征
- 批准号:
10224721 - 财政年份:2019
- 资助金额:
$ 40万 - 项目类别:
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