Neural representation of mating partners by male C. elegans

雄性线虫对交配伙伴的神经表征

基本信息

项目摘要

Project Summary Understanding how neural circuits create animal behavior requires knowing the system-wide activity patterns that connect sensory experience to motor activities, all within the full set of feedback loops by which actuated motor decisions modulate the animal's perceptions of itself and the outside world during naturally executed and unrestrained behaviors. Mechanistic understanding further requires interpretation of system-wide activity patterns in terms of the connectivity, synaptic, and cellular properties of all relevant neurons. Modeling requires comprehensive mapping of the salient dimensions of sensory input and motor output, as well as how high- dimensional neural activity patterns are properly projected, by decision-making and the internal constraints of the nervous system and motor system, into the fewer dimensions that characterize any animal's observed behavior. Such models are facilitated by using animals where entire brain and motor circuits can be mapped and interrogated with full molecular and cellular resolution. Here, we will use the mating behavior of the male C. elegans as such a paradigm. The mating behavior of C. elegans is a critically important and goal-directed task that occurs in natural environments and is robustly executed in the laboratory. Males use a specialized circuit of ~100 neurons – sensory neurons, interneurons, neuromodulatory, and motor neurons – all contained within the male tail ganglia to locate hermaphrodites, locate the vulva along the hermaphrodite's body, and initiate and complete insemination. A diverse set of mechanosensory, chemosensory, and pheromone sensing neurons are used to recognize the shape, texture, and chemical signature of the hermaphrodite body. Several neurons are specialized to detect fiducial points along the hermaphrodite body. The male implicitly uses an internal representation of the size, shape, and predictable behaviors of the hermaphrodite to positively recognize the hermaphrodite, infer its own position along the hermaphrodite, and execute an optimal movement strategy to maintain contact with the hermaphrodite and find and penetrate the vulva. It is now possible to record neural activity from the entire set of neurons in the male tail with high temporal resolution and complete cellular resolution. We will couple experiments, modern data analysis and modeling methods, and cellular and molecular genetic perturbations to elucidate the full set of sensorimotor events that organize the mating behavior. We will develop a realistic model of the circuit that integrates the observable behavioral algorithms with the connectivity and activity patterns of the male tail ganglion. We will apply genetic tools to identify and elucidate each sensory neuron type, and how it affects each aspect of decision-making by downstream interneurons and motor neurons. We will characterize key synaptic properties by molecular dissection of neurotransmitter and receptor types. We will store this comprehensive neurophysiological and neurogenetic data in online project databases connected to our computational models that will allow the wider community to view and probe our data-driven modeling eff ort.
项目摘要 了解神经回路如何创造动物行为需要了解整个系统的活动模式 连接感官体验和运动活动,所有这些都在一整套反馈回路中, 运动决策调节动物在自然执行过程中对自身和外部世界的感知, 不受约束的行为要理解机制,还需要解释全系统的活动 所有相关神经元的连接性、突触和细胞特性的模式。建模需要 全面绘制感觉输入和运动输出的突出维度,以及 三维神经活动模式被适当地投射,通过决策和内部约束, 神经系统和运动系统,到较少的维度,表征任何动物的观察 行为这种模型是通过使用动物来促进的,在动物中,整个大脑和运动回路可以被映射, 用完整的分子和细胞分辨率进行询问。在这里,我们将使用雄性C的交配行为。 elegans作为这样一个范例。对C. elegans是一项非常重要的目标导向任务 在自然环境中发生,并在实验室中稳健地执行。雄性使用一种特殊的 ~100个神经元-感觉神经元、中间神经元、神经调节神经元和运动神经元-全部包含在 雄性尾神经节定位雌雄同体,沿着雌雄同体的身体沿着定位外阴,并启动和 完全人工授精一组不同的机械感觉、化学感觉和信息素感觉神经元是 用来识别雌雄同体身体的形状、质地和化学特征。一些神经元 专门用来检测沿着雌雄同体身体的基准点。男性含蓄地使用内部 代表的大小,形状,和可预测的行为的雌雄同体积极认识到, 它可以确定自己的位置,沿着雌雄同体,并执行最佳运动策略, 保持与雌雄同体的接触,找到并插入外阴。现在可以记录神经 来自雄性尾部整组神经元的活动具有高时间分辨率和完整的细胞 分辨率我们将结合实验,现代数据分析和建模方法,以及细胞和分子 遗传扰动,以阐明组织交配行为的全套感觉运动事件。我们将 开发一个现实的电路模型,将可观察的行为算法与连接性相结合 以及雄性尾神经节的活动模式我们将应用遗传工具来识别和阐明每一种感觉 神经元类型,以及它如何影响下游中间神经元和运动神经元决策的各个方面。 我们将通过神经递质和受体类型的分子解剖来表征关键的突触特性。我们 将把这些全面的神经生理学和神经遗传学数据存储在在线项目数据库中, 我们的计算模型,这将允许更广泛的社区查看和探索我们的数据驱动的建模 结果。

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
PEZO-1 and TRP-4 mechanosensors are involved in mating behavior in Caenorhabditis elegans.
  • DOI:
    10.1093/pnasnexus/pgac213
  • 发表时间:
    2022-11
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Brugman, Katherine I.;Susoy, Vladislav;Whittaker, Allyson J.;Palma, Wilber;Nava, Stephanie;Samuel, Aravinthan D. T.;Sternberg, Paul W.
  • 通讯作者:
    Sternberg, Paul W.
Weighing the evidence in sharp-wave ripples.
在锐波涟漪中权衡证据。
  • DOI:
    10.1016/j.neuron.2022.01.036
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    16.2
  • 作者:
    Linderman,ScottW
  • 通讯作者:
    Linderman,ScottW
Generalized Shape Metrics on Neural Representations.
神经表示的广义形状度量。
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Scott Warren Linderman其他文献

Scott Warren Linderman的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Scott Warren Linderman', 18)}}的其他基金

Unified, Scalable, and Reproducible Neurostatistical Software
统一、可扩展且可重复的神经统计软件
  • 批准号:
    10725500
  • 财政年份:
    2023
  • 资助金额:
    $ 65.68万
  • 项目类别:
CRCNS: Deconstructing dynamics of motor cortex in freely moving behavior
CRCNS:解构自由运动行为中运动皮层的动力学
  • 批准号:
    10666693
  • 财政年份:
    2022
  • 资助金额:
    $ 65.68万
  • 项目类别:
CRCNS: Deconstructing dynamics of motor cortex in freely moving behavior
CRCNS:解构自由运动行为中运动皮层的动力学
  • 批准号:
    10610495
  • 财政年份:
    2022
  • 资助金额:
    $ 65.68万
  • 项目类别:
Neural representation of mating partners by male C. elegans
雄性线虫对交配伙伴的神经表征
  • 批准号:
    10457866
  • 财政年份:
    2019
  • 资助金额:
    $ 65.68万
  • 项目类别:
Neural representation of mating partners by male C. elegans
雄性线虫对交配伙伴的神经表征
  • 批准号:
    10224721
  • 财政年份:
    2019
  • 资助金额:
    $ 65.68万
  • 项目类别:

相似海外基金

EXCESS: The role of excess topography and peak ground acceleration on earthquake-preconditioning of landslides
过量:过量地形和峰值地面加速度对滑坡地震预处理的作用
  • 批准号:
    NE/Y000080/1
  • 财政年份:
    2024
  • 资助金额:
    $ 65.68万
  • 项目类别:
    Research Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
  • 批准号:
    2328975
  • 财政年份:
    2024
  • 资助金额:
    $ 65.68万
  • 项目类别:
    Continuing Grant
SHINE: Origin and Evolution of Compressible Fluctuations in the Solar Wind and Their Role in Solar Wind Heating and Acceleration
SHINE:太阳风可压缩脉动的起源和演化及其在太阳风加热和加速中的作用
  • 批准号:
    2400967
  • 财政年份:
    2024
  • 资助金额:
    $ 65.68万
  • 项目类别:
    Standard Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
  • 批准号:
    2328973
  • 财政年份:
    2024
  • 资助金额:
    $ 65.68万
  • 项目类别:
    Continuing Grant
Market Entry Acceleration of the Murb Wind Turbine into Remote Telecoms Power
默布风力涡轮机加速进入远程电信电力市场
  • 批准号:
    10112700
  • 财政年份:
    2024
  • 资助金额:
    $ 65.68万
  • 项目类别:
    Collaborative R&D
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
  • 批准号:
    2328972
  • 财政年份:
    2024
  • 资助金额:
    $ 65.68万
  • 项目类别:
    Continuing Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
  • 批准号:
    2328974
  • 财政年份:
    2024
  • 资助金额:
    $ 65.68万
  • 项目类别:
    Continuing Grant
Collaborative Research: A new understanding of droplet breakup: hydrodynamic instability under complex acceleration
合作研究:对液滴破碎的新认识:复杂加速下的流体动力学不稳定性
  • 批准号:
    2332916
  • 财政年份:
    2024
  • 资助金额:
    $ 65.68万
  • 项目类别:
    Standard Grant
Collaborative Research: A new understanding of droplet breakup: hydrodynamic instability under complex acceleration
合作研究:对液滴破碎的新认识:复杂加速下的流体动力学不稳定性
  • 批准号:
    2332917
  • 财政年份:
    2024
  • 资助金额:
    $ 65.68万
  • 项目类别:
    Standard Grant
Study of the Particle Acceleration and Transport in PWN through X-ray Spectro-polarimetry and GeV Gamma-ray Observtions
通过 X 射线光谱偏振法和 GeV 伽马射线观测研究 PWN 中的粒子加速和输运
  • 批准号:
    23H01186
  • 财政年份:
    2023
  • 资助金额:
    $ 65.68万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了