A self-capacitance driven wearable electromyometrial imaging system for maternal and fetal monitoring during pregnancy and labor

一种自电容驱动的可穿戴式肌电成像系统，用于妊娠和分娩期间的母婴监测

• 批准号: 10666402
• 负责人: Chuan Wang
• 金额: $ 33.47万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666402
• 关键词: 3-Dimensional; Abdomen; Address; Adoption; Area; Benchmarking; Birth; Body Surface; Body of uterus; Brain; Cerebral Palsy; Child; Clinical; Clinical Treatment; Data; Delivery Rooms; Electric Capacitance; Electrodes; Engineering; Fetal Monitoring; Fetal Mortality Statistics; Geometry; Health; Heart; Heart failure; Home; Human; Image; Imaging technology; Impaired cognition; Joints; Knowledge; Magnetic Resonance Imaging; Maps; Measurement; Measures; Medical center; Mental Retardation; Methods; Monitor; Morphologic artifacts; Motion; Organ; Outcome; Outpatients; Pathologic; Patients; Pattern; Performance; Perinatology; Persons; Pregnancy; Pregnant Women; Premature Birth; Premature Labor; Printing; Research; Research Activity; Resolution; Risk; Schedule; Signal Transduction; Site; Surface; System; Technology; Telemetry; Transducers; Translating; United States; Universities; Uterine Contraction; Uterine Monitoring; Uterus; Validation; Visual impairment; Washington; Wireless Charging; clinical application; clinical translation; cohort; cost; density; design; effectiveness evaluation; electrical property; hearing impairment; human subject; imaging platform; imaging study; imaging system; improved; instrument; instrumentation; mechanical properties; member; new technology; novel; patient mobility; portability; prevent; sensor; temporal measurement; tool; treatment strategy; wireless

PROJECT SUMMARY Approximately 10% of pregnant women give birth preterm In the United States and worldwide, which not only results in a high rate of fetal mortality but also puts the children at a lifelong risk of negative health consequences such as cerebral palsy, mental retardation, and visual and hearing impairments. Despite years of research, the mechanisms of initiation and propagation of uterine contractions resulting in preterm labor and birth remain unknown. In large part, this is because of our limited ability to monitor the human uterine contractions with sufficient spatial and temporal resolutions. This leads to a lack of critical knowledge of the pathologic factors that alter the normal uterine maturation, initiate preterm labor, and result in preterm birth. In order to address this unmet clinical and research need, our team has recently developed a novel high-resolution and noninvasive electromyometrial imaging (EMMI) system, which uses up to 256 unipolar electrodes to measure uterine electrograms from the patient's abdomen surface and then combines the patient-specific body-uterus geometry obtained by magnetic resonance imaging (MRI) to generate accurate and robust three-dimensional maps of uterine electrical activity during contractions. Because such a powerful experimental tool could permit closer and more precise study of birth-related risks and improve maternal and child outcomes, we believe there could be a significant clinical impact for us to develop a low-cost, wireless, and wearable version in order to make this imaging technology more accessible for outpatient or in-home monitoring settings. We propose to develop and validate the functionality of a unique wearable EMMI system with printed disposable electrodes, wireless power delivery, and telemetry for continuously monitoring of the uterine contraction activities in ambulatory patients. The proposed research activity will involve developing of ultrathin soft sensor patches with printed stretchable electrodes for recording high quality electrograms from the patient’s abdomen and generating accurate and robust 3D maps of the uterine surface; investigating and designing a novel self-capacitance based wireless power transfer instrumentation for wirelessly powering all the sensing and telemetry circuits at each recording site in a fully distributed high-density imaging system; validating the wireless and wearable EMMI system in human subjects and benchmarking its performance against “gold standard” wired EMMI system. Upon successful completion of this study, the entirely new wearable, wireless, and batteryless imaging system developed in the project will facilitate EMMI's clinical translations, allow it to be used outside the delivery room for outpatient setting or in-home monitoring applications, and ultimately enable us to leverage the electrical mapping data for evaluating uterine electrical maturation and contraction patterns during pregnancy and labor and use the results to better understand and treat preterm birth.

项目摘要 在美国和全世界，大约10%的孕妇早产，这不仅 导致高胎儿死亡率，但也使儿童终身面临负面健康后果的风险 例如大脑性麻痹、智力迟钝、视力和听力障碍。尽管经过多年的研究， 导致早产和分娩的子宫收缩的启动和传播机制仍然存在 未知在很大程度上，这是因为我们监测人类子宫收缩的能力有限， 空间和时间分辨率。这导致对病理因素缺乏批判性了解， 改变正常的子宫成熟，引发早产，导致早产。为了解决这一 为了满足临床和研究需求，我们的团队最近开发了一种新型的高分辨率且非侵入性的 子宫肌电成像（EMMI）系统，使用多达256个单极电极测量子宫 然后将患者特定的身体-子宫几何形状 通过磁共振成像（MRI）获得，以生成准确和强大的三维图， 子宫收缩时的电活动。因为这样一个强大的实验工具可以允许更接近和 更精确地研究与出生有关的风险，改善孕产妇和儿童的结果，我们相信， 显著的临床影响，我们开发一个低成本，无线，可穿戴版本，以使这一点， 成像技术更容易用于门诊或家庭监测设置。 我们建议开发和验证一个独特的可穿戴EMMI系统的功能， 一次性电极、无线电力输送和遥测，用于连续监测子宫 门诊患者的收缩活动。拟议的研究活动将涉及开发 具有印刷可拉伸电极的软传感器贴片，用于记录来自患者的高质量电描记图， 腹部，并生成准确和强大的子宫表面3D地图;研究和设计一个 新型的基于自电容的无线功率传输仪器，用于无线地为所有感测和 遥测电路在每个记录站点在一个完全分布式的高密度成像系统;验证无线 和可穿戴的EMMI系统，并将其性能与“黄金标准”有线 EMMI系统。在成功完成这项研究后，全新的可穿戴，无线和无电池 该项目中开发的成像系统将促进EMMI的临床翻译，使其能够在 用于门诊设置或家庭监测应用的产房，并最终使我们能够利用 用于评估妊娠期间子宫电成熟和收缩模式的电标测数据 并努力使用结果来更好地理解和治疗早产。

项目成果

A Portable and a Scalable Multi-Channel Wireless Recording System for Wearable Electromyometrial Imaging.

用于可穿戴肌电成像的便携式且可扩展的多通道无线记录系统。

• DOI: 10.1109/tbcas.2023.3278104
• 发表时间: 2023
• 期刊: IEEE transactions on biomedical circuits and systems
• 影响因子: 5.1
• 作者: Li,Weilun;Xiao,Zhili;Zhao,Junyi;Aono,Kenji;Pizzella,Stephanie;Wen,Zichao;Wang,Yong;Wang,Chuan;Chakrabartty,Shantanu
• 通讯作者: Chakrabartty,Shantanu