Data and Analytics Core

数据和分析核心

• 批准号: 10633143
• 负责人: AMBER L. MOSLEY
• 金额: $ 24.61万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-06 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633143
• 关键词: Animal Model; Atherogenic Diet; Biotechnology; Body Composition; Breeding; Calories; Catheters; Chemicals; Cholesterol; Clinical Medicine; Collaborations; Complex; Control Groups; Corvus; Data; Diabetes Mellitus; Diet; Dyslipidemias; Endocrine; Family suidae; Fasting; Funding; Glucose; Glucose Clamp; Health; High Density Lipoproteins; Human; Implant; Indiana; Informatics; Insulin Resistance; Intervention; Intravenous; Kidney Calculi; Licensing; Lipids; Lithotripsy; Liver; Low-Density Lipoproteins; Medicine; Metabolic; Metabolic syndrome; Metabolism; Methods; Microscopy; Miniature Swine; Modeling; Molecular; Monitor; National Heart, Lung, and Blood Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Oral; Pathogenesis; Phenotype; Physiology; Positron-Emission Tomography; Production; Research; Research Personnel; Resource Sharing; Resources; Rodent; Services; Severities; Skeletal Muscle; Stents; System; Testing; Therapeutic; Thinness; Tissue Banks; Tissues; Transgenic Mice; Translational Research; Translations; Triglycerides; Ultrasonography; Universities; X-Ray Computed Tomography; bariatric surgery; comorbidity; comparative; cost effectiveness; cost efficient; data repository; diabetic; human disease; human model; imaging study; impaired glucose tolerance; improved; in vivo; indexing; islet; medical schools; metabolic abnormality assessment; mouse model; operation; translation to humans

ABSTRACT (SWINE CORE) The Swine Core of the Indiana Diabetes Research Center is a Regional/National Shared Resource Core that has been operating and servicing researchers since 2004. The central function of the Swine Core is to reduce barriers to the use of Ossabaw swine, a unique animal model that closely approximates human metabolic syndrome (MetS) and progression to type 2 diabetes, with attendant long-term complications. Understanding and therapeutic treatment of MetS and diabetes with numerous long-term health complications in humans has been stifled by the lack of translational animal models. Experimental methods and translation to human clinical medicine is not possible from widely used rodent and transgenic mouse models. The Swine Core will characterize MetS and progression to type 2 diabetes and/or chemically-induced diabetes (MetS/D) and the resulting comorbidities in Ossabaw swine. We have provided Ossabaw tissue and/or live pigs to ~160 investigators during the 15 years of the Swine Core operation. A bank of ~50 different tissues available from each pig has enabled widespread dissemination to other investigators, providing outstanding resource sharing and cost-effectiveness. Providing this swine resource enables testing of numerous hypotheses about the integrated, in vivo pathogenesis and long-term complications and provides tissues for studies of cellular and molecular mechanisms. The Swine Core is a critical interface in the translation of research from simpler animal models (Islet & Physiology Core) to humans (Translation Core). The Swine Core is Directed by Dr. M. Sturek, a leader in modeling human diseases in swine, and Dr. M. Alloosh serves as the Associate Director. The Specific Aims of the Swine Core are to: (1). Make lean and diet-induced MetS and diabetic (MetS/D) pigs readily available, i.e. “on the shelf”. (2). Determine the endocrine, metabolic, and dyslipidemia indices of MetS/D to screen for optimal phenotypes. (3). Provide a tissue and data bank for distribution. These aims of the Swine Core will reduce barriers to study of this highly relevant animal model, and will facilitate the progressive translation of research from simpler, less complex models to humans.

摘要（猪芯） 印第安纳州糖尿病研究中心的猪核心是一个区域/国家共享资源核心， 自2004年以来一直为研究人员提供服务。猪芯的核心功能是减少 Ossabaw猪是一种非常接近人类代谢的独特动物模型， 综合征（MetS）和进展为2型糖尿病，伴随长期并发症。理解 和治疗性治疗代谢综合征和糖尿病与许多长期的健康并发症的人， 由于缺乏可转化的动物模型而被扼杀。实验方法和人类临床翻译 从广泛使用的啮齿动物和转基因小鼠模型中不可能获得药物。猪的核心将 表征MetS和向2型糖尿病和/或化学诱导的糖尿病（MetS/D）的进展， 导致Ossabaw猪的合并症。我们已向约160头Ossabaw组织和/或生猪提供 在猪芯操作的15年期间，约50种不同组织的库，可从 每只猪都能广泛传播给其他研究人员，提供出色的资源共享 和成本效益。提供这种猪资源使得能够测试关于猪的许多假设。 整合，在体内发病机制和长期并发症，并提供组织的研究细胞和 分子机制猪的核心是一个关键的接口，在翻译的研究，从简单的动物 模型（胰岛和生理学核心）到人类（翻译核心）。猪的核心是由博士M。斯图雷克， 在猪身上模拟人类疾病的领导者，M。Alloosh担任副主任。的 猪核心的具体目标是： （一）.使瘦猪和饮食诱导的MetS和糖尿病（MetS/D）猪容易获得，即“货架上”。 （二）、确定MetS/D的内分泌、代谢和血脂异常指标，以筛选最佳代谢指标。 表型 （三）、提供组织和数据库以供分发。 猪核心的这些目标将减少研究这种高度相关的动物模型的障碍， 促进研究从简单、不太复杂的模型到人类的逐步转化。