Core D: Neurocircuitry and Behavior Core

项目摘要：神经回路和行为核心(NBC) 神经回路和行为核心(NBC)的主要目标是提供最先进的服务， 促进对智力和发育障碍(IDD)的终身研究--从受孕到 成人期，为农村人口量身定做。核心将支持与鹰相关的研究项目- IDDRC同时利用动物和人类，以及那些交叉受精的翻译方法 从寿命角度研究碘缺乏病。核心由两个单位组成：1)神经影像部门(NID) 2)神经电路与行为分部(NCBD)。NID将协助开发， 在动物模型和人类中实施和完成神经成像研究。 神经成像设备将侧重于评估大脑结构、功能和新陈代谢的成像技术。 所提供的资源将包括大脑成像的以下方面的专门知识：a)开发 新的成像工具、脉冲序列和设备；b)实施图像采集协议；c) 实施和部署标准图像分析管道；d)开发新的图像分析 战略；以及e)数据管理、生物信息学和成像数据的统计支持。NCBD将 提供神经回路功能、行为(如社交、睡眠)和认知(如学习)方面的专业知识 和记忆)在动物模型和人类中使用个人通常无法获得的工具 实验室。对于使用动物模型的研究，NCBD将提供设施和服务来帮助调查人员 进行行为分析。在人类研究方面，NCBD在研究人类方面拥有重要的专业知识 并将设计和实施认知范式来研究神经 电路，这可以应用于智力和发育障碍的个人以及控制。 最后，NID和NCBD能够根据调查人员的要求进行实验，或将提供 必要的培训，使实验室人员能够在设施中进行实验。 全国广播公司将整合和利用加州大学现有的强大资源。 爱荷华州包括爱荷华州生物医学成像研究所(IIBI)和爱荷华州神经科学研究所(INI)。工具 作为NBC的一部分开发的数据将与全国各地的IDD调查人员共享。全国广播公司将会 支持27个联邦资助的项目(每年1130万美元)，并将建立在现有强大合作的基础上 使用动物模型的基础科学家和从事人脑研究的临床科学家之间的联系。在……里面 此外，NBC将帮助加强科学家与IDD社区和他们之间的关系 家庭，其中许多住在农村地区，帮助促进合作，使更好地理解 从寿命的角度来看，缺乏症的风险。

PROJECT SUMMARY: NEUROCIRCUITRY AND BEHAVIOR CORE (NBC) The primary objective of the Neurocircuitry and Behavior Core (NBC) is to provide state-of-the-art services that foster studies of intellectual and developmental disability (IDD) across the lifespan—from conception to adulthood, tailored to a rural population. The Core will support research projects affiliated with the Hawk- IDDRC that utilize both animals and humans as well as those that cross-fertilize a translational approach to the study of IDD from a lifespan perspective. The Core is made up of two units: 1) Neuroimaging Division (NID) and 2) Neural Circuits and Behavior Division (NCBD). The NID will assist in the development, implementation, and completion of neuroimaging research studies in animal models as well as humans. Neuroimaging modalities will focus on imaging techniques to assess brain structure, function, and metabolism. The resources provided will include expertise in the following aspects of brain imaging: a) development of novel imaging tools, pulse sequences, and equipment; b) implementation of protocols for image acquisition; c) implementation and deployment of standard image analysis pipelines; d) development of novel image analysis strategies; and e) data management, bioinformatics, and statistical support for imaging data. The NCBD will provide expertise in neural circuit function, behavior (e.g. social interaction, sleep), and cognition (e.g. learning and memory) in animal models and humans using tools that are often not available within individual laboratories. For studies using animal models, the NCBD will provide facilities and services to aid investigators performing behavioral assays. For human studies, the NCBD has significant expertise in studying human behavior and cognition across the lifespan and will design and implement cognitive paradigms to study neural circuits, which can be applied to individuals with intellectual and developmental disabilities as well as controls. Finally, the NID and NCBD are able to conduct experiments as requested by investigators, or will provide the necessary training to enable laboratory personnel to perform experiments in the facility. The NBC will integrate and capitalize upon strong existing resources currently available at the University of Iowa including the Iowa Institute for Biomedical Imaging (IIBI) and the Iowa Neuroscience Institute (INI). Tools that are developed as part of the NBC will be shared with IDD investigators across the country. The NBC will support 27 federally funded projects ($11.3 million per year) and will build upon strong existing collaborations between basic scientists who use animal models and clinical scientists engaged in human brain studies. In addition, the NBC will help strengthen the relationship between scientists and the IDD community and their families, many of whom live in rural areas, helping foster collaborations that will enable a better understanding of IDD from a lifespan perspective.