Activin in Testicular Development and Disease

激活素在睾丸发育和疾病中的作用

• 批准号: nhmrc : 545917
• 负责人: A/Pr Mark Hedger
• 金额: $ 34.09万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/activin-testicular-development-disease/76638
• 关键词: Activin; Testicular; Development; Disease

A man's reproductive health and fertility is affected by processes that occur long before adulthood. The testis and sperm precursor cells first form in the fetus and then grow until the time of puberty, when the upper limit for sperm production is set. This project studies how one key signaling molecule, activin, helps establish normal testicular architecture and drives maturation of sperm precursor cells, and how it contributes to aberrent function in men with testicular cancer.

男性的生殖健康和生育能力受到成年前很久发生的过程的影响。睾丸和精子前体细胞首先在胎儿中形成，然后生长到青春期，此时精子产生的上限被设定。该项目研究一种关键的信号分子激活素如何帮助建立正常的睾丸结构并驱动精子前体细胞的成熟，以及它如何有助于睾丸癌患者的异常功能。