Activin A and follistatin are potential key regulators of organ transplant dysfunction and graft survival.

激活素 A 和卵泡抑素是器官移植功能障碍和移植物存活的潜在关键调节剂。

• 批准号: nhmrc : 1048094
• 负责人: A/Pr Mark Hedger
• 金额: $ 35.71万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/activin-follistatin-potential-graft-survival/111999
• 关键词: Activin; follistatin; potential; key; regulators

The grant examines novel key regulators in organ transplantation. It examines molecules that are released during transplant surgery and on the return of blood flow to the organ which can cause inflammation and scarring. The release is increased by heparin, an anticoagulant used in organ preparation. Alternative anticoagulants and blockers of the regulators released will be tested to prevent the damage to the transplant, potentially improving both the short and long term graft survival and function.

该补助金审查了器官移植中的新的关键监管机构。它检查在移植手术中释放的分子，以及血液回流到器官时释放的分子，这些分子可能导致炎症和疤痕。肝素是一种用于器官准备的抗凝剂，可以增加释放。将测试释放的调节剂的替代抗凝剂和阻断剂，以防止对移植物的损害，可能改善短期和长期移植物存活和功能。