Collaborative Pediatric Critical Care Research Network - Clinical Site
儿科重症监护协作研究网络 - 临床网站
基本信息
- 批准号:10667490
- 负责人:
- 金额:$ 12.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-18 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
ABSTRACT – University of Colorado Denver
With our participation in this iteration of the Collaborative Pediatric Critical Care Research Network (CPCCRN),
we contributed to a series of discoveries that enhanced our understanding of disease processes and resulted in
a multitude of potentially effective treatments for critically ill and injured children that require definitive evaluation
in clinical trials. There continues to be tremendous need for a collaborative research network in pediatric critical
care to facilitate the swift and effective translation of scientific and technologic discoveries into clinical advances.
Access to appropriate patients and expertise in the execution of clinical trials must be linked to scientists and
laboratories working within and across disciplines at the cutting edge of scientific advancement. At the University
of Colorado Denver (UCD) and Children’s Hospital Colorado (CHCO), we have a long history of successful
collaborative basic, translational, and clinical science programs focused on pediatric critical illness and injury.
We will provide several unique areas of strength to the CPCCRN, including: 1) a distinctive multidisciplinary team
of collaborative researchers with specific expertise in mechanistic investigations of cardiovascular and
pulmonary diseases, 2) a proven and successful track record as a clinical site in CPCCRN, 3) expertise with
pediatric clinical trials execution, including innovative programs to enhance positive research culture among
clinical staff and participation among patients and families, 4) a 7-state catchment area with high volumes of
critically ill and injured children, 5) an in-house rehabilitation program and extensive outpatient outreach program
capable of providing follow-up care to nearly all our critically ill patients, and 6) a dynamic partnership with the
Children’s Hospital Colorado Research Institute and Colorado Clinical Translational Science Institute to provide
extensive research resources. Our ancillary site, Arkansas Children’s Hospital (ACH) provides 1) experience
with pediatric clinical trials execution, including previous successful membership in CPCCRN 2) provision of care
to nearly all of the critically ill children from the State of Arkansas and a 4-state catchment area, 3) representation
of an Institutional Development Award (IDeA) state (historically received low levels of NIH support) and involving
their unique populations (rural, Marshallese, and medically underserved communities) in the NIH mission, and
4) a rich partnership with the ACH Research Institute and University of Arkansas Clinical Translational Science
Award to provide comprehensive research resources. Utilizing these assets, we will augment the contributions
of CPCCRN to the care of critically ill children through rigorous clinical trial execution, innovative translational
and clinical trial proposals, participation in CPCCRN leadership committees, and training the next generation of
pediatric critical care researchers. The proposed trial of “Personalized Immunomodulation in Sepsis induced
Multiple Organ Dysfunction Syndrome” is an incredibly innovative approach that moves beyond a “one therapy
for all” paradigm to an individualized therapeutic approach that will dramatically improve outcomes for children
with sepsis. We are enthusiastic and committed to participate in this project with the new 24-site CPCCRN.
摘要-科罗拉多大学丹佛分校
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Eva S. Nozik其他文献
Nbeal2 knockout mice are not protected against hypoxia-induced pulmonary vascular remodeling and pulmonary hypertension
Nbeal2基因敲除小鼠对缺氧诱导的肺血管重构和肺动脉高压没有保护作用
- DOI:
10.1182/bloodadvances.2024013880 - 发表时间:
2025-04-08 - 期刊:
- 影响因子:7.100
- 作者:
Janelle N. Posey;Mariah Jordan;Caitlin V. Lewis;Christina Sul;Evgenia Dobrinskikh;Delaney Swindle;Frederik Denorme;David Irwin;Jorge Di Paola;Kurt Stenmark;Eva S. Nozik;Cassidy Delaney - 通讯作者:
Cassidy Delaney
Eva S. Nozik的其他文献
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{{ truncateString('Eva S. Nozik', 18)}}的其他基金
R35 Administrative Supplements to Recognize Excellencein Diversity, Equity, Inclusion, and Accessibility (DEIA)Mentorship
R35 表彰多元化、公平、包容性和可及性 (DEIA) 指导方面卓越表现的行政补充
- 批准号:
10630461 - 财政年份:2022
- 资助金额:
$ 12.6万 - 项目类别:
Collaborative Pediatric Critical Care Research Network - Clinical Site
儿科重症监护协作研究网络 - 临床网站
- 批准号:
10470946 - 财政年份:2021
- 资助金额:
$ 12.6万 - 项目类别:
SOD3 regulation of redox sensitive signaling in pulmonary vascular diseases
SOD3 对肺血管疾病中氧化还原敏感信号的调节
- 批准号:
10847902 - 财政年份:2018
- 资助金额:
$ 12.6万 - 项目类别:
SOD3 regulation of redox sensitive signaling in pulmonary vascular diseases
SOD3 对肺血管疾病中氧化还原敏感信号的调节
- 批准号:
10433989 - 财政年份:2018
- 资助金额:
$ 12.6万 - 项目类别:
SOD3 regulation of redox sensitive signaling in pulmonary vascular diseases
SOD3 对肺血管疾病中氧化还原敏感信号的调节
- 批准号:
10610425 - 财政年份:2018
- 资助金额:
$ 12.6万 - 项目类别:
SOD3 regulation of redox sensitive signaling in pulmonary vascular diseases
SOD3 对肺血管疾病中氧化还原敏感信号的调节
- 批准号:
10237868 - 财政年份:2018
- 资助金额:
$ 12.6万 - 项目类别:
DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
肺动脉高压细胞外超氧化物歧化酶 DNA 甲基化
- 批准号:
8335465 - 财政年份:2011
- 资助金额:
$ 12.6万 - 项目类别:
Regulation of extracellular superoxide dismutase in human pulmonary arterial hype
细胞外超氧化物歧化酶在人肺动脉高压中的调节
- 批准号:
8210797 - 财政年份:2011
- 资助金额:
$ 12.6万 - 项目类别:
Extracellular superoxide induces Egr-1 in the hypoxic pulmonary artery
细胞外超氧化物在缺氧肺动脉中诱导 Egr-1
- 批准号:
7841072 - 财政年份:2009
- 资助金额:
$ 12.6万 - 项目类别:
Extracellular superoxide induces Egr-1 in the hypoxic pulmonary artery
细胞外超氧化物在缺氧肺动脉中诱导 Egr-1
- 批准号:
8197441 - 财政年份:2007
- 资助金额:
$ 12.6万 - 项目类别:
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