Collaborative Pediatric Critical Care Research Network - Clinical Site

儿科重症监护协作研究网络 - 临床网站

基本信息

  • 批准号:
    10667490
  • 负责人:
  • 金额:
    $ 12.6万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-08-18 至 2026-07-31
  • 项目状态:
    未结题

项目摘要

ABSTRACT – University of Colorado Denver With our participation in this iteration of the Collaborative Pediatric Critical Care Research Network (CPCCRN), we contributed to a series of discoveries that enhanced our understanding of disease processes and resulted in a multitude of potentially effective treatments for critically ill and injured children that require definitive evaluation in clinical trials. There continues to be tremendous need for a collaborative research network in pediatric critical care to facilitate the swift and effective translation of scientific and technologic discoveries into clinical advances. Access to appropriate patients and expertise in the execution of clinical trials must be linked to scientists and laboratories working within and across disciplines at the cutting edge of scientific advancement. At the University of Colorado Denver (UCD) and Children’s Hospital Colorado (CHCO), we have a long history of successful collaborative basic, translational, and clinical science programs focused on pediatric critical illness and injury. We will provide several unique areas of strength to the CPCCRN, including: 1) a distinctive multidisciplinary team of collaborative researchers with specific expertise in mechanistic investigations of cardiovascular and pulmonary diseases, 2) a proven and successful track record as a clinical site in CPCCRN, 3) expertise with pediatric clinical trials execution, including innovative programs to enhance positive research culture among clinical staff and participation among patients and families, 4) a 7-state catchment area with high volumes of critically ill and injured children, 5) an in-house rehabilitation program and extensive outpatient outreach program capable of providing follow-up care to nearly all our critically ill patients, and 6) a dynamic partnership with the Children’s Hospital Colorado Research Institute and Colorado Clinical Translational Science Institute to provide extensive research resources. Our ancillary site, Arkansas Children’s Hospital (ACH) provides 1) experience with pediatric clinical trials execution, including previous successful membership in CPCCRN 2) provision of care to nearly all of the critically ill children from the State of Arkansas and a 4-state catchment area, 3) representation of an Institutional Development Award (IDeA) state (historically received low levels of NIH support) and involving their unique populations (rural, Marshallese, and medically underserved communities) in the NIH mission, and 4) a rich partnership with the ACH Research Institute and University of Arkansas Clinical Translational Science Award to provide comprehensive research resources. Utilizing these assets, we will augment the contributions of CPCCRN to the care of critically ill children through rigorous clinical trial execution, innovative translational and clinical trial proposals, participation in CPCCRN leadership committees, and training the next generation of pediatric critical care researchers. The proposed trial of “Personalized Immunomodulation in Sepsis induced Multiple Organ Dysfunction Syndrome” is an incredibly innovative approach that moves beyond a “one therapy for all” paradigm to an individualized therapeutic approach that will dramatically improve outcomes for children with sepsis. We are enthusiastic and committed to participate in this project with the new 24-site CPCCRN.
摘要-科罗拉多大学丹佛分校 随着我们参与这次儿科重症监护协作研究网络(CPCCRN)的迭代, 我们对一系列发现做出了贡献,这些发现增强了我们对疾病过程的理解,并导致了 对危重和受伤儿童的多种可能有效的治疗方法需要明确的评估 在临床试验中。儿科危重病的协作研究网络仍有巨大的需求 关心促进科学和技术发现迅速有效地转化为临床进步。 在执行临床试验时接触到适当的患者和专业知识必须与科学家和 在科学进步的前沿学科内部和跨学科开展工作的实验室。在大学里 在科罗拉多州丹佛(UCD)和科罗拉多州儿童医院(CHCO),我们有很长的成功历史 协作性基础、翻译和临床科学项目,重点关注儿科危重疾病和损伤。 我们将为CPCCRN提供几个独特的优势领域,包括:1)一个独特的多学科团队 在心血管和心脏疾病的机械研究方面具有特殊专长的合作研究人员组成的 肺部疾病,2)作为CPCCRN临床站点的经过验证和成功的记录,3)专业知识 儿科临床试验执行,包括促进积极研究文化的创新方案 临床工作人员和患者和家属的参与,4)7个州的集水区,有大量 危重和受伤儿童,5)内部康复计划和广泛的门诊外展计划 能够为我们几乎所有的危重病人提供后续护理,以及6)与 科罗拉多州儿童医院研究所和科罗拉多州临床翻译科学研究所提供 丰富的研究资源。我们的附属网站阿肯色州儿童医院(ACH)提供1)体验 执行儿科临床试验,包括以前成功加入CPCCRN 2)提供护理 几乎所有来自阿肯色州和四个州集水区的危重儿童,3)代表 机构发展奖(IDEA)州(历史上NIH获得的支持水平较低),并参与 他们在NIH任务中的独特人口(农村、马绍尔人和医疗服务不足的社区),以及 4)与ACH研究所和阿肯色州临床翻译科学大学建立了丰富的合作伙伴关系 奖项提供全面的研究资源。利用这些资产,我们将增加捐款 CPCCRN通过严格的临床试验执行、创新的翻译和 和临床试验提案,参与CPCCRN领导委员会,并培训下一代 儿科重症监护研究人员。“个体化免疫调节在脓毒症治疗中的建议试验” “多器官功能障碍综合症”是一种令人难以置信的创新方法,它超越了“一种疗法” 对于所有人都是一种个性化的治疗方法,这将显著改善儿童的结局 患有败血症。我们热心并致力于与新的24个站点的CPCCRN一起参与这一项目。

项目成果

期刊论文数量(0)
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会议论文数量(0)
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Eva S. Nozik其他文献

Nbeal2 knockout mice are not protected against hypoxia-induced pulmonary vascular remodeling and pulmonary hypertension
Nbeal2基因敲除小鼠对缺氧诱导的肺血管重构和肺动脉高压没有保护作用
  • DOI:
    10.1182/bloodadvances.2024013880
  • 发表时间:
    2025-04-08
  • 期刊:
  • 影响因子:
    7.100
  • 作者:
    Janelle N. Posey;Mariah Jordan;Caitlin V. Lewis;Christina Sul;Evgenia Dobrinskikh;Delaney Swindle;Frederik Denorme;David Irwin;Jorge Di Paola;Kurt Stenmark;Eva S. Nozik;Cassidy Delaney
  • 通讯作者:
    Cassidy Delaney

Eva S. Nozik的其他文献

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{{ truncateString('Eva S. Nozik', 18)}}的其他基金

R35 Administrative Supplements to Recognize Excellencein Diversity, Equity, Inclusion, and Accessibility (DEIA)Mentorship
R35 表彰多元化、公平、包容性和可及性 (DEIA) 指导方面卓越表现的行政补充
  • 批准号:
    10630461
  • 财政年份:
    2022
  • 资助金额:
    $ 12.6万
  • 项目类别:
Collaborative Pediatric Critical Care Research Network - Clinical Site
儿科重症监护协作研究网络 - 临床网站
  • 批准号:
    10470946
  • 财政年份:
    2021
  • 资助金额:
    $ 12.6万
  • 项目类别:
SOD3 regulation of redox sensitive signaling in pulmonary vascular diseases
SOD3 对肺血管疾病中氧化还原敏感信号的调节
  • 批准号:
    10847902
  • 财政年份:
    2018
  • 资助金额:
    $ 12.6万
  • 项目类别:
SOD3 regulation of redox sensitive signaling in pulmonary vascular diseases
SOD3 对肺血管疾病中氧化还原敏感信号的调节
  • 批准号:
    10433989
  • 财政年份:
    2018
  • 资助金额:
    $ 12.6万
  • 项目类别:
SOD3 regulation of redox sensitive signaling in pulmonary vascular diseases
SOD3 对肺血管疾病中氧化还原敏感信号的调节
  • 批准号:
    10610425
  • 财政年份:
    2018
  • 资助金额:
    $ 12.6万
  • 项目类别:
SOD3 regulation of redox sensitive signaling in pulmonary vascular diseases
SOD3 对肺血管疾病中氧化还原敏感信号的调节
  • 批准号:
    10237868
  • 财政年份:
    2018
  • 资助金额:
    $ 12.6万
  • 项目类别:
DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
肺动脉高压细胞外超氧化物歧化酶 DNA 甲基化
  • 批准号:
    8335465
  • 财政年份:
    2011
  • 资助金额:
    $ 12.6万
  • 项目类别:
Regulation of extracellular superoxide dismutase in human pulmonary arterial hype
细胞外超氧化物歧化酶在人肺动脉高压中的调节
  • 批准号:
    8210797
  • 财政年份:
    2011
  • 资助金额:
    $ 12.6万
  • 项目类别:
Extracellular superoxide induces Egr-1 in the hypoxic pulmonary artery
细胞外超氧化物在缺氧肺动脉中诱导 Egr-1
  • 批准号:
    7841072
  • 财政年份:
    2009
  • 资助金额:
    $ 12.6万
  • 项目类别:
Extracellular superoxide induces Egr-1 in the hypoxic pulmonary artery
细胞外超氧化物在缺氧肺动脉中诱导 Egr-1
  • 批准号:
    8197441
  • 财政年份:
    2007
  • 资助金额:
    $ 12.6万
  • 项目类别:

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儿科重症监护协作研究网络
  • 批准号:
    10468842
  • 财政年份:
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  • 资助金额:
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  • 批准号:
    10670224
  • 财政年份:
    2021
  • 资助金额:
    $ 12.6万
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儿科重症监护协作研究网络 - 临床网站
  • 批准号:
    10670235
  • 财政年份:
    2021
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儿科重症监护协作研究网络 - 临床网站
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    10670281
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    2021
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  • 财政年份:
    2021
  • 资助金额:
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儿科重症监护协作研究网络 - 临床网站
  • 批准号:
    10470937
  • 财政年份:
    2021
  • 资助金额:
    $ 12.6万
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儿科重症监护协作研究网络 - 临床网站
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    10470944
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    $ 12.6万
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儿科重症监护协作研究网络 - 临床网站
  • 批准号:
    10393865
  • 财政年份:
    2021
  • 资助金额:
    $ 12.6万
  • 项目类别:
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