R35 Administrative Supplements to Recognize Excellencein Diversity, Equity, Inclusion, and Accessibility (DEIA)Mentorship

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Abstract This is a request for an administrative supplement to R35 HL139726 SOD3 regulation of redox sensitive signaling in pulmonary vascular diseases to increase diversity, equity and inclusion in biomedical research by supporting pre-doctoral student, Thi-Tina Nguyen. Thi-Tina Nguyen is a predoctoral student in the Integrative Physiology Graduate Program at the University of Colorado Anschutz Medical Campus and will be joining the Nozik lab in July 2022 for her PhD thesis work. She meets criteria for this program based on being from a disadvantaged background according to the NIH criteria. Ms Nguyen has identified an interest in studying how maternal factors that impair EC-SOD expression lead to dysregulated redox signaling in the lung and pulmonary vasculature of the offspring. Specifically, she plans to build upon the lab's published observations that 1) insufficient EC-SOD (SOD3) worsens neonatal lung and vascular development in neonatal mouse models, as well as chronic hypoxic pulmonary hypertension in adult mice; 2) prenatal hypoxic exposure of pregnant rats reduced pup lung EC-SOD content; 3) exercise increases placental derived EC-SOD in the maternal circulation and protects the fetal liver; and 3) low EC-SOD content modulates macrophage reprogramming in pulmonary vascular diseases. Based on these observations, Ms Nguyen has developed a research plan to investigate how hypoxia in late gestation impacts lung EC-SOD, lung and pulmonary vascular development and macrophage phenotype in the offspring after birth and into young adulthood. This work will provide a foundation for an individual F31 application to expand upon this work. The proposal outlines both the scientific proposal and a summary of the career development plan for Ms. Nguyen.