Core C Molecular Informatics Core

摘要 分子信息学核心 分子信息学模块将为蛋白质组学和代谢组学/同位素组学研究策略提供帮助 和技术的研究人员参与这一P30科尔眼睛视觉研究核心。开发所需的时间 蛋白质组学和代谢组学技术的专业知识往往会给有能力的研究人员带来研究障碍， 其他专业技能。具体而言，该模块将提供1）实验设计咨询，技术支持， 数据分析，用于正常和患病眼组织和细胞系统中的整体和靶向蛋白定量，包括 蛋白质组学生物信息学; 2）集中的蛋白质组学研究策略资源和视觉科学的技术支持 研究涉及蛋白质鉴定、蛋白质-蛋白质相互作用和翻译后修饰; 3）实验 为正常和患病眼部组织和细胞系统的代谢组学分析提供设计咨询和技术支持; 以及4）代谢组学研究策略的集中资源和视觉科学研究的技术支持，包括 代谢组学生物信息学该核心模块将支持NEI R 01资助的调查员，帮助新招募的 研究人员获得NEI R 01资助提交的数据，促进RO 1资助的研究人员之间的协作互动 和新招募的研究人员，吸引其他部门的研究人员研究视觉系统，并成为一个 在吸引更多的视觉科学家到我们的计划，因为我们扩大我们的研究人员的宝贵部门资源。

Abstract Molecular Informatics Core The Molecular Informatics Module will provide assistance with proteomic and metabolomic/isotopomic research strategies and technologies to the investigators involved in this P30 Cole Eye Vision Research Core. The time required to develop expertise in proteomic and metabolomic technologies often generates research roadblocks to capable investigators with other specialized skills. Specifically, the module will provide 1) experimental design consultation, technical support, and data analysis for global and targeted protein quantitation in normal and diseased ocular tissues and cell systems, including proteomic bioinformatics; 2) a centralized resource for proteomic research strategy and technical support for vision science studies involving protein identification, protein-protein interactions and posttranslational modifications; 3) experimental design consultation and technical support for metabolomic profiling in normal and diseased ocular tissues and cell systems; and 4) a centralized resource for metabolomic research strategy and technical support for vision science studies, including metabolomic bioinformatics. This core module will support NEI R01-funded investigators, help newly recruited investigators obtain data for NEI R01 grant submissions, foster collaborative interactions between RO1-funded investigators and newly recruited investigators, attract investigators from other departments to research on the visual system and be a valuable departmental resource in attracting additional vision scientists to our program as we expand our research faculty.