Development of a Respiratory Sensor for Animal Model Research

用于动物模型研究的呼吸传感器的开发

• 批准号: 10697651
• 负责人: MyPhuong T Le
• 金额: $ 39.56万
• 依托单位: AQUILLIUS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-15 至 2024-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10697651
• 关键词: Air; Air Movements; Algorithms; Anesthesia procedures; Animal Model; Animals; Automobile Driving; Biomedical Research; Breathing; Calibration; California; Caring; Cause of Death; Cessation of life; Chest; Collaborations; Colorado; Computer software; Conscious; Coupling; Data; Detection; Development; Devices; Elements; Event; Exhalation; Feasibility Studies; Film; Future; Goals; Health; Human; Inhalation; Lung; Maps; Measurement; Measures; Mechanical ventilation; Mechanics; Medical; Methods; Mind; Modeling; Monitor; Movement; Mus; Nanotechnology; Noise; Patient Care; Patients; Pattern; Peak Expiratory Flow; Persons; Phase; Pilot Projects; Procedures; Property; Pulmonary function tests; Rattus; Reproducibility; Research; Research Personnel; Respiration; Respiratory Disease; Respiratory Therapy; Rodent; Signal Transduction; System; Technology; Testing; Thinness; Tidal Volume; Time; Transducers; Translations; Universities; Veterinarians; Whole Body Plethysmography; animal data; awake; chemical stability; chronic respiratory disease; cost; cost effective; data acquisition; design; disability; electrical impedance tomography; experimental study; flexibility; graphene; high volume manufacturing; improved; lung volume; manufacturability; manufacture; manufacturing process; microelectronics; nanomaterials; nanosheet; phase 1 study; prototype; pulmonary function; real time monitoring; respiratory; response; restraint; sensor; stress reduction; tool; translational impact; usability; wearable device; wearable sensor technology

Project Summary / Abstract Over half a billion people worldwide currently suffer from a chronic respiratory disease and is the third leading cause of deaths and disability, and thus, responsible for 4 million deaths a year. The ability to accurately monitor and measure pulmonary functions in animal models, especially in rodents, is critical to advancing our understanding of normal lung functions and, importantly, the mechanisms driving the development and progression of respiratory diseases. By improving the translation of animal data, new respiratory therapies can be developed, thus allowing clinicians and veterinarians to better care for their patients. However, performing pulmonary function tests in animals, especially in small animals, such as rats and mice, is extremely challenging. Current methods require anesthesia, restraint, or is invasive, thus negatively impacting their breathing patterns. This results in the introduction of errors into the data, resulting in irreproducibility of experiments and reducing their translational impact on improving human health. Additionally, current technologies are expensive and ineffective due to limited capacity. To overcome the current limitations in performing pulmonary function tests in small animals, Aquillius Corporation is proposing proof-of-concept pilot studies to develop a non-invasive sensor capable of real-time monitoring and measuring of pulmonary function. Easily applied to unrestrained and awake animals, the respiratory sensor will reduce stress to both the animals and researchers, thus enhancing the usability and reproducibility of data. Using graphene nanomaterials, the sensor will be cost-effective, robust, and can be adapted for future use in larger animals and in humans. Thus, the proposed development of a respiratory sensor that continuously monitors pulmonary functions will be an invaluable tool that can advance biomedical research and improve patient care. Upon completion of Phase I feasibility studies, we will have developed and validated the respiratory sensor’s capabilities for measuring pulmonary function in rats. We plan to submit for a Phase II proposal to develop manufacturing process controls and refine end-user interface and software with the goal of finalizing a commercially ready respiratory sensor.

项目总结/摘要 目前，全世界有超过5亿人患有慢性呼吸道疾病， 是导致死亡和残疾的主要原因，因此每年造成400万人死亡。的能力 准确监测和测量动物模型，特别是啮齿动物的肺功能， 推进我们对正常肺功能的理解，重要的是， 呼吸道疾病的发展和进展。通过改进动物数据的翻译， 可以开发呼吸疗法，从而使临床医生和兽医能够更好地照顾他们的 患者然而，在动物中进行肺功能测试，特别是在小动物中，例如大鼠， 和老鼠，是非常具有挑战性的。目前的方法需要麻醉，约束，或者是侵入性的，因此 对他们的呼吸模式产生负面影响。这导致在数据中引入错误， 实验的不可重复性和减少其对改善人类健康的转化影响。 此外，由于能力有限，目前的技术是昂贵和无效的。 为了克服目前在小动物中进行肺功能测试的局限性， 该公司正在提出概念验证试点研究，以开发一种能够实时 肺功能的监测和测量。很容易应用于无拘无束和清醒的动物， 呼吸传感器将减少对动物和研究人员的压力，从而提高可用性， 数据的再现性。使用石墨烯纳米材料，传感器将具有成本效益，坚固耐用，并且可以 适应于未来在更大的动物和人类中使用。因此，建议开发呼吸道 持续监测肺功能的传感器将是一个宝贵的工具，可以促进生物医学 研究和改善病人护理。 在第一阶段可行性研究完成后，我们将开发和验证呼吸系统 传感器测量大鼠肺功能的能力。我们计划提交第二阶段提案， 开发制造过程控制，完善最终用户界面和软件， 商用呼吸传感器。