Development of a Respiratory Sensor for Animal Model Research
用于动物模型研究的呼吸传感器的开发
基本信息
- 批准号:10697651
- 负责人:
- 金额:$ 39.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-15 至 2024-06-14
- 项目状态:已结题
- 来源:
- 关键词:AirAir MovementsAlgorithmsAnesthesia proceduresAnimal ModelAnimalsAutomobile DrivingBiomedical ResearchBreathingCalibrationCaliforniaCaringCause of DeathCessation of lifeChestCollaborationsColoradoComputer softwareConsciousCouplingDataDetectionDevelopmentDevicesElementsEventExhalationFeasibility StudiesFilmFutureGoalsHealthHumanInhalationLungMapsMeasurementMeasuresMechanical ventilationMechanicsMedicalMethodsMindModelingMonitorMovementMusNanotechnologyNoisePatient CarePatientsPatternPeak Expiratory FlowPersonsPhasePilot ProjectsProceduresPropertyPulmonary function testsRattusReproducibilityResearchResearch PersonnelRespirationRespiratory DiseaseRespiratory TherapyRodentSignal TransductionSystemTechnologyTestingThinnessTidal VolumeTimeTransducersTranslationsUniversitiesVeterinariansWhole Body Plethysmographyanimal dataawakechemical stabilitychronic respiratory diseasecostcost effectivedata acquisitiondesigndisabilityelectrical impedance tomographyexperimental studyflexibilitygraphenehigh volume manufacturingimprovedlung volumemanufacturabilitymanufacturemanufacturing processmicroelectronicsnanomaterialsnanosheetphase 1 studyprototypepulmonary functionreal time monitoringrespiratoryresponserestraintsensorstress reductiontooltranslational impactusabilitywearable devicewearable sensor technology
项目摘要
Project Summary / Abstract
Over half a billion people worldwide currently suffer from a chronic respiratory disease and is the third
leading cause of deaths and disability, and thus, responsible for 4 million deaths a year. The ability to
accurately monitor and measure pulmonary functions in animal models, especially in rodents, is critical to
advancing our understanding of normal lung functions and, importantly, the mechanisms driving the
development and progression of respiratory diseases. By improving the translation of animal data, new
respiratory therapies can be developed, thus allowing clinicians and veterinarians to better care for their
patients. However, performing pulmonary function tests in animals, especially in small animals, such as rats
and mice, is extremely challenging. Current methods require anesthesia, restraint, or is invasive, thus
negatively impacting their breathing patterns. This results in the introduction of errors into the data, resulting in
irreproducibility of experiments and reducing their translational impact on improving human health.
Additionally, current technologies are expensive and ineffective due to limited capacity.
To overcome the current limitations in performing pulmonary function tests in small animals, Aquillius
Corporation is proposing proof-of-concept pilot studies to develop a non-invasive sensor capable of real-time
monitoring and measuring of pulmonary function. Easily applied to unrestrained and awake animals, the
respiratory sensor will reduce stress to both the animals and researchers, thus enhancing the usability and
reproducibility of data. Using graphene nanomaterials, the sensor will be cost-effective, robust, and can be
adapted for future use in larger animals and in humans. Thus, the proposed development of a respiratory
sensor that continuously monitors pulmonary functions will be an invaluable tool that can advance biomedical
research and improve patient care.
Upon completion of Phase I feasibility studies, we will have developed and validated the respiratory
sensor’s capabilities for measuring pulmonary function in rats. We plan to submit for a Phase II proposal to
develop manufacturing process controls and refine end-user interface and software with the goal of finalizing a
commercially ready respiratory sensor.
项目摘要/摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('MyPhuong T Le', 18)}}的其他基金
Utilization of Phytochemicals to Ameliorate Fructose-Induced Fatty Liver through
利用植物化学物质改善果糖诱导的脂肪肝
- 批准号:
8900968 - 财政年份:2014
- 资助金额:
$ 39.56万 - 项目类别:
Utilization of Phytochemicals to Ameliorate Fructose-Induced Fatty Liver through
利用植物化学物质改善果糖诱导的脂肪肝
- 批准号:
8768130 - 财政年份:2014
- 资助金额:
$ 39.56万 - 项目类别: