Development of a Respiratory Sensor for Animal Model Research

用于动物模型研究的呼吸传感器的开发

• 批准号: 10697651
• 负责人: MyPhuong T Le
• 金额: $ 39.56万
• 依托单位: AQUILLIUS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-15 至 2024-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10697651
• 关键词: Air; Air Movements; Algorithms; Anesthesia procedures; Animal Model; Animals; Automobile Driving; Biomedical Research; Breathing; Calibration; California; Caring; Cause of Death; Cessation of life; Chest; Collaborations; Colorado; Computer software; Conscious; Coupling; Data; Detection; Development; Devices; Elements; Event; Exhalation; Feasibility Studies; Film; Future; Goals; Health; Human; Inhalation; Lung; Maps; Measurement; Measures; Mechanical ventilation; Mechanics; Medical; Methods; Mind; Modeling; Monitor; Movement; Mus; Nanotechnology; Noise; Patient Care; Patients; Pattern; Peak Expiratory Flow; Persons; Phase; Pilot Projects; Procedures; Property; Pulmonary function tests; Rattus; Reproducibility; Research; Research Personnel; Respiration; Respiratory Disease; Respiratory Therapy; Rodent; Signal Transduction; System; Technology; Testing; Thinness; Tidal Volume; Time; Transducers; Translations; Universities; Veterinarians; Whole Body Plethysmography; animal data; awake; chemical stability; chronic respiratory disease; cost; cost effective; data acquisition; design; disability; electrical impedance tomography; experimental study; flexibility; graphene; high volume manufacturing; improved; lung volume; manufacturability; manufacture; manufacturing process; microelectronics; nanomaterials; nanosheet; phase 1 study; prototype; pulmonary function; real time monitoring; respiratory; response; restraint; sensor; stress reduction; tool; translational impact; usability; wearable device; wearable sensor technology

Project Summary / Abstract Over half a billion people worldwide currently suffer from a chronic respiratory disease and is the third leading cause of deaths and disability, and thus, responsible for 4 million deaths a year. The ability to accurately monitor and measure pulmonary functions in animal models, especially in rodents, is critical to advancing our understanding of normal lung functions and, importantly, the mechanisms driving the development and progression of respiratory diseases. By improving the translation of animal data, new respiratory therapies can be developed, thus allowing clinicians and veterinarians to better care for their patients. However, performing pulmonary function tests in animals, especially in small animals, such as rats and mice, is extremely challenging. Current methods require anesthesia, restraint, or is invasive, thus negatively impacting their breathing patterns. This results in the introduction of errors into the data, resulting in irreproducibility of experiments and reducing their translational impact on improving human health. Additionally, current technologies are expensive and ineffective due to limited capacity. To overcome the current limitations in performing pulmonary function tests in small animals, Aquillius Corporation is proposing proof-of-concept pilot studies to develop a non-invasive sensor capable of real-time monitoring and measuring of pulmonary function. Easily applied to unrestrained and awake animals, the respiratory sensor will reduce stress to both the animals and researchers, thus enhancing the usability and reproducibility of data. Using graphene nanomaterials, the sensor will be cost-effective, robust, and can be adapted for future use in larger animals and in humans. Thus, the proposed development of a respiratory sensor that continuously monitors pulmonary functions will be an invaluable tool that can advance biomedical research and improve patient care. Upon completion of Phase I feasibility studies, we will have developed and validated the respiratory sensor’s capabilities for measuring pulmonary function in rats. We plan to submit for a Phase II proposal to develop manufacturing process controls and refine end-user interface and software with the goal of finalizing a commercially ready respiratory sensor.

项目概要/摘要 目前全世界有超过 5 亿人患有慢性呼吸道疾病，是第三大疾病 死亡和残疾的主要原因，因此每年导致 400 万人死亡。有能力 准确监测和测量动物模型（尤其是啮齿类动物）的肺功能对于 增进我们对正常肺功能的理解，更重要的是，了解驱动肺功能的机制 呼吸系统疾病的发生和进展。通过改进动物数据的翻译，新 可以开发呼吸疗法，从而使临床医生和兽医能够更好地照顾他们的 患者。然而，对动物进行肺功能测试，尤其是小动物，例如大鼠 和老鼠，极具挑战性。目前的方法需要麻醉、约束或侵入性，因此 对他们的呼吸方式产生负面影响。这会导致数据中引入错误，从而导致 实验的不可重复性并减少其对改善人类健康的转化影响。 此外，由于容量有限，当前的技术昂贵且低效。 为了克服目前在小动物中进行肺功能测试的局限性，Aquillius 公司正在提议进行概念验证试点研究，以开发一种能够实时检测的非侵入式传感器 监测和测量肺功能。很容易应用于不受约束和清醒的动物， 呼吸传感器将减轻动物和研究人员的压力，从而提高可用性和 数据的再现性。使用石墨烯纳米材料，该传感器将具有成本效益、坚固耐用，并且可以 适合未来用于大型动物和人类。因此，建议开发一种呼吸系统 持续监测肺功能的传感器将成为推动生物医学发展的宝贵工具 研究并改善患者护理。 第一阶段可行性研究完成后，我们将开发并验证呼吸系统 传感器测量大鼠肺功能的能力。我们计划提交第二阶段提案 开发制造过程控制并完善最终用户界面和软件，以最终确定 商用呼吸传感器。