Career Enhancement Program

项目摘要（职业提升计划） 职业提升计划（CEP）的目标是为学术医师提供培训和指导 希望奉献自己的职业和研究的科学家、临床研究人员和实验室科学家 致力于转化癌症表观遗传学研究。为实现这一目标，CEP将采取以下措施 具体目标： 1. 招募、培养和指导优秀的医生、科学家和高级博士后 研究人员专注于癌症表观遗传学转化研究。 2. 对获奖者进行癌症表观遗传学生物学所有基本原理的教育，包括分子、细胞 和系统生物学、药物开发、药代动力学和药效学研究以及基础 生物统计学和生物信息学原理。 3. 为癌症表观遗传学转化和早期特定领域的获奖者提供坚实的基础 临床研究。 这些目标将通过强有力的指导来实现，获奖者将接受指导原则 临床、基础和转化癌症表观遗传学研究。教育的具体领域可能包括科学 和临床方法、生物医学伦理学、统计设计和分析、生物信息学、生物学、生物化学、 遗传学、流行病学以及与个别项目相关的其他领域。指导将包括基于实验室的 研究人员、临床转化研究人员、生物统计学家、生物信息学家和流行病学家。导师 来自 Van Andel 研究所表观遗传治疗 SPORE——勇敢地面对癌症表观遗传学梦想 团队、Coriell 研究所、Van Andel 研究所以及 PI 机构以及 IAB 和 EAB 成员将 提供发展强大、富有成效的转化研究技能所需的专业知识。

PROJECT SUMMARY (Career Enhancement Program) The goal of the Career Enhancement Program (CEP) is to provide training and guidance for academic physician- scientists, clinician-investigators, and laboratory-based scientists who wish to dedicate their career and research efforts to translational cancer epigenetics research. To achieve this goal, the CEP will pursue the following specific aims: 1. Recruit, train, and mentor physicians, scientists, and senior postdoctoral fellows to become excellent investigators focused on cancer epigenetics translational research. 2. Educate awardees in all the basic principles of cancer epigenetics biology, including molecular, cellular and systems biology, drug development, pharmacokinetic and pharmacodynamics studies, and basic principles of biostatistics and bioinformatics. 3. Provide a firm foundation for awardees in the specific area of cancer epigenetics translational and early clinical research. These objectives will be achieved through strong mentorship in which awardees will be instructed in the principles of clinical, basic, and translational cancer epigenetics research. Specific areas of education may include scientific and clinical methods, biomedical ethics, statistical design and analysis, bioinformatics, biology, biochemistry, genetics, epidemiology, and other areas relevant to individual projects. Mentorship will include laboratory-based investigators, clinical-translational investigators, biostatisticians, bioinformaticians and epidemiologists. Mentors from within the Epigenetic Therapy SPORE, the Van Andel Institute-Stand Up To Cancer Epigenetics Dream Team, Coriell Institute, the Van Andel Institute, and institutions of PIs and members of the IAB and EAB will provide the expertise required for the development of strong, productive translational research skills.