Biostatistics and Computational Biology Core - Core B

生物统计学和计算生物学核心 - 核心 B

基本信息

批准号：
10696106
负责人：
WENDY Beth LONDON
金额：
$ 16.01万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-19 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10696106
关键词：
Animals Area Bioinformatics Biological Markers Biometry Clinical Clinical Protocols Clinical Trials Code Collaborations Computational Biology Computing Methodologies Consult Consultations Data Data Analyses Data Collection Data Science Data Set Databases Dedications Development Event Extramural Activities Fostering Funding Futility Genomics Glioma Grant Guidelines Health protection Human Image Investigation Laboratories Laboratory Study Leadership Manuscripts Measurement Medical Methodology Methods Mission Modeling Molecular Monitor Outcome Pathology Patients Pre-Clinical Model Preparation Process Proteomics Reporting Reproducibility Research Research Personnel Resources Role Safety Security Statistical Data Interpretation Statistical Methods Statistical Models Techniques Time Tissues Translating United States National Institutes of Health Variant Work anticancer research clinical translation clinical trial analysis complex data cost data exchange data management data resource design experimental study high standard indexing laboratory experiment metabolomics novel pre-clinical programs research study scientific hub symposium targeted treatment translational study

项目摘要

This Glioma SPORE will require statistical and bioinformatics collaboration on a wide variety of research, ranging from pre-clinical models to human studies. The mission of the Biostatistics and Computational Biology Core of this glioma SPORE is to foster rigor and reproducibility. Towards this end, the core will work with project leaders to insure statistical integrity in the design of their experiments and interpretation of their data. The Biostatistics and Computational Biology Core will function as a scientific hub to facilitate interand intra- SPORE collaborations between all Projects and with the Pathology Core. The core will advise on all issues related to data collection, analysis and interpretation. The core will provide 1) ready and dedicated resources for database and computing requirements, 2) consultation and expertise on the development and implementation of plans for data collection, particularly the coding convention and variable format required for statistical analysis, 3) advice on the data management plan, including form design and database requirements, during development of the SPORE-related clinical trials, 4) expertise and resources for data transfer, merging, sharing and security while maintaining the confidentiality of all patient-related protected health information, 5) statistical expertise for the design, planning and conduct of preclinical experiments, clinical trials and correlative tissue and biomarker studies, 6) analysis of the clinical trials and interim monitoring and analysis, if necessary, including the stopping rules for safety and futility, 7) statistical and bioinformatics expertise for inference and interpretation of research studies, including manuscript preparation.

这种神经胶质瘤孢子将需要各种研究的统计和生物信息学协作，从临床前模型到人类研究。生物统计学和计算的任务该神经胶质瘤孢子的生物学核心是促进严格和可重复性。为此，核心将起作用在项目领导者的设计中确保统计完整性的实验和解释数据。生物统计学和计算生物学核心将充当科学枢纽，以促进间和所有项目与病理核心之间的孢子内合作。核心将为所有人提供建议与数据收集，分析和解释有关的问题。核心将提供1）准备和专用数据库和计算要求的资源，2）关于开发的咨询和专业知识以及实施数据收集计划，尤其是编码约定和所需的可变格式统计分析，3）有关数据管理计划的建议，包括表单设计和数据库要求，在开发与孢子相关的临床试验的开发过程中，4）数据传输，合并，共享和安全性，同时保持所有与患者有关的保护健康信息的机密性，5）临床前实验，临床试验的设计，计划和行为的统计专业知识和相关组织和生物标志物研究，6）分析临床试验和临时监测和分析，如果必要的，包括安全和徒劳的停止规则，7）统计和生物信息学专业知识研究研究的推论和解释，包括手稿准备。