Research training in respiratory biology

呼吸生物学研究培训

• 批准号: 10696963
• 负责人: Yun Fang
• 金额: $ 88.92万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-08-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10696963
• 关键词: Biology; Research Training; respiratory

PROJECT SUMMARY The objective of our competing renewal application for the Univ of Chicago Research Training Program in Respiratory Biology is to prepare young scientists to pursue research careers addressing mechanisms and treatment of human disease, with a focus on respiratory pathobiology. The cohesiveness of this interdiscipli- nary Program stems from the highly collaborative nature of our 38 well-funded faculty in 7 departments and the Institute for Molecular Engineering at the Univ of Chicago in multiple areas of concentration. Studies in Asthma and Airway Physiology/Immunology continue to focus on airway inflammation, airway smooth muscle and epithelial structure and function, B-cell and T-cell activation, asthma genetics, and clinical investigation. These complement programs of Studies in Lung Immunology and Transplantation that focus on cellular and molecular mechanisms underlying transplantation immunology and their translational applications to patients, and translational Studies in Interstitial Lung Diseases that draw on one of the largest dedicated clinics in the Midwest. A Concentration in Airway and Mucosal Microbiome adds this critically important emerging research direction to the asthma and ILD programs. Studies in Critical Illness and Acute Lung Injury continue to address subcellular determinants of oxygen sensing and consumption, cellular responses to hypoxia, membrane biology, endothelial and epithelial barrier function, and bedside translations to patients with sepsis, cardiopulmonary arrest, and sleep disturbance. Complementing these are cross-cutting Studies in Genetics and Epigenetics and Concentration in Health Studies and Ethics. The Program Directors are Anne I. Sperling, PhD and Julian Solway, MD, with Associate Director Steven White, MD (Mentorship and Career Development). Christopher Olopade, MD, MPH chairs a Diversity Committee. Internal and External Advisors provide oversight and continuity of review, and an Admissions/Steering Committee reviews trainee progress. We request funding for 10 post-doctoral trainees. PhD, MD, and MD/PhD trainees are enrolled and trained together. Collaboration of basic and clinical scientists on research further enhances the integrative and translational nature of our program. All fellows perform full-time research for at least 2 years, and MD fellows will devote not more than 10% time to clinical training while supported by this Program. Training consists of 5 major components: a Research Project performed under the direct supervision of faculty co-mentors; a Core Curriculum of robust seminar series and courses with additional, tailored formal coursework; Core Competencies that includes scientific communication, grant writing, and mentoring; Multidisciplinary Research; and Individualized Career Development Planning. Prior trainees from this Program have developed successful independent research careers in large proportion. Refinements presented here should further enhance the likelihood for success of future trainees.

项目摘要 我们的目标是竞争更新申请的芝加哥大学研究培训计划， 呼吸生物学是准备年轻的科学家追求研究事业解决机制， 治疗人类疾病，重点是呼吸道病理学。这种跨学科的凝聚力- nary计划源于我们的38个资金充足的教师在7个部门和高度协作的性质， 芝加哥大学分子工程研究所在多个集中领域。哮喘研究 和气道生理学/免疫学继续关注气道炎症、气道平滑肌和 上皮结构和功能，B细胞和T细胞活化，哮喘遗传学和临床研究。这些 肺免疫学和移植研究的补充计划，重点是细胞和分子 移植免疫学的潜在机制及其对患者的转化应用，以及 间质性肺疾病的转化研究，利用美国最大的专门诊所之一， 中西部。气道和粘液微生物组的浓度增加了这一至关重要的新兴研究 哮喘和ILD项目的方向。危重病和急性肺损伤研究继续探讨 氧感受和消耗的亚细胞决定因素，细胞对缺氧的反应，膜 生物学，内皮和上皮屏障功能，以及败血症患者的床边翻译， 心肺骤停和睡眠障碍补充这些是遗传学的交叉研究 和表观遗传学和集中在健康研究和伦理学。项目负责人是安妮。斯珀林， 博士和朱利安索尔韦，医学博士，与副主任史蒂芬白色，医学博士（导师和职业发展）。 克里斯托弗Olopade，医学博士，公共卫生硕士主持多样性委员会。内部和外部顾问提供监督 和审查的连续性，招生/指导委员会审查学员的进展。我们要求资金 10名博士后研究生。博士、医学博士和医学博士/博士学员一起注册和培训。协作 基础和临床科学家的研究进一步加强了我们的综合和转化性质， 程序.所有研究员进行全职研究至少2年，和MD研究员将投入不超过 在本计划的支持下，10%的时间用于临床培训。培训由5个主要部分组成： 在教师共同导师的直接监督下进行的研究项目;强大的核心课程 研讨会系列和课程，以及额外的定制正式课程;核心竞争力，包括 科学交流，资助写作和指导;多学科研究;和个性化的职业生涯 发展规划。该计划的受训人员已经成功地开展了独立研究 职业生涯占很大比例。这里提出的改进应进一步提高成功的可能性， 未来的实习生

项目成果

IL-6 Inhibition in Critically Ill COVID-19 Patients Is Associated With Increased Secondary Infections.

重症患者的IL-6抑制作用与继发感染增加有关。

• DOI: 10.3389/fmed.2020.583897
• 发表时间: 2020
• 期刊: Frontiers in medicine
• 影响因子: 3.9
• 作者: Kimmig LM;Wu D;Gold M;Pettit NN;Pitrak D;Mueller J;Husain AN;Mutlu EA;Mutlu GM
• 通讯作者: Mutlu GM

External Validation of an Acute Respiratory Distress Syndrome Prediction Model Using Radiology Reports.

• DOI: 10.1097/ccm.0000000000004468
• 发表时间: 2020-09
• 期刊: Critical care medicine
• 影响因子: 8.8
• 作者: Mayampurath A;Churpek MM;Su X;Shah S;Munroe E;Patel B;Dligach D;Afshar M
• 通讯作者: Afshar M

Corticosteroid therapy and airflow obstruction influence the bronchial microbiome, which is distinct from that of bronchoalveolar lavage in asthmatic airways.

• DOI: 10.1016/j.jaci.2015.10.017
• 发表时间: 2016-05
• 期刊: The Journal of allergy and clinical immunology
• 作者: Denner DR;Sangwan N;Becker JB;Hogarth DK;Oldham J;Castillo J;Sperling AI;Solway J;Naureckas ET;Gilbert JA;White SR
• 通讯作者: White SR

Non-canonical functions of RGS proteins.

• DOI: 10.1016/j.cellsig.2010.03.016
• 发表时间: 2010-09
• 期刊: Cellular signalling
• 影响因子: 4.8
• 作者: Sethakorn N;Yau DM;Dulin NO
• 通讯作者: Dulin NO

HIF-1α induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury.

• DOI: 10.7554/elife.77457
• 发表时间: 2022-07-13
• 期刊: ELIFE
• 影响因子: 7.7
• 作者: Woods, Parker S.;Kimmig, Lucas M.;Sun, Kaitlyn A.;Meliton, Angelo Y.;Shamaa, Obada R.;Tian, Yufeng;Cetin-Atalay, Renguel;Sharp, Willard W.;Hamanaka, Robert B.;Mutlu, Goekhan M.
• 通讯作者: Mutlu, Goekhan M.