Research training in respiratory biology

呼吸生物学研究培训

基本信息

  • 批准号:
    10696963
  • 负责人:
  • 金额:
    $ 88.92万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1985
  • 资助国家:
    美国
  • 起止时间:
    1985-08-01 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY The objective of our competing renewal application for the Univ of Chicago Research Training Program in Respiratory Biology is to prepare young scientists to pursue research careers addressing mechanisms and treatment of human disease, with a focus on respiratory pathobiology. The cohesiveness of this interdiscipli- nary Program stems from the highly collaborative nature of our 38 well-funded faculty in 7 departments and the Institute for Molecular Engineering at the Univ of Chicago in multiple areas of concentration. Studies in Asthma and Airway Physiology/Immunology continue to focus on airway inflammation, airway smooth muscle and epithelial structure and function, B-cell and T-cell activation, asthma genetics, and clinical investigation. These complement programs of Studies in Lung Immunology and Transplantation that focus on cellular and molecular mechanisms underlying transplantation immunology and their translational applications to patients, and translational Studies in Interstitial Lung Diseases that draw on one of the largest dedicated clinics in the Midwest. A Concentration in Airway and Mucosal Microbiome adds this critically important emerging research direction to the asthma and ILD programs. Studies in Critical Illness and Acute Lung Injury continue to address subcellular determinants of oxygen sensing and consumption, cellular responses to hypoxia, membrane biology, endothelial and epithelial barrier function, and bedside translations to patients with sepsis, cardiopulmonary arrest, and sleep disturbance. Complementing these are cross-cutting Studies in Genetics and Epigenetics and Concentration in Health Studies and Ethics. The Program Directors are Anne I. Sperling, PhD and Julian Solway, MD, with Associate Director Steven White, MD (Mentorship and Career Development). Christopher Olopade, MD, MPH chairs a Diversity Committee. Internal and External Advisors provide oversight and continuity of review, and an Admissions/Steering Committee reviews trainee progress. We request funding for 10 post-doctoral trainees. PhD, MD, and MD/PhD trainees are enrolled and trained together. Collaboration of basic and clinical scientists on research further enhances the integrative and translational nature of our program. All fellows perform full-time research for at least 2 years, and MD fellows will devote not more than 10% time to clinical training while supported by this Program. Training consists of 5 major components: a Research Project performed under the direct supervision of faculty co-mentors; a Core Curriculum of robust seminar series and courses with additional, tailored formal coursework; Core Competencies that includes scientific communication, grant writing, and mentoring; Multidisciplinary Research; and Individualized Career Development Planning. Prior trainees from this Program have developed successful independent research careers in large proportion. Refinements presented here should further enhance the likelihood for success of future trainees.
项目总结

项目成果

期刊论文数量(224)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
IL-6 Inhibition in Critically Ill COVID-19 Patients Is Associated With Increased Secondary Infections.
重症患者的IL-6抑制作用与继发感染增加有关。
  • DOI:
    10.3389/fmed.2020.583897
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    3.9
  • 作者:
    Kimmig LM;Wu D;Gold M;Pettit NN;Pitrak D;Mueller J;Husain AN;Mutlu EA;Mutlu GM
  • 通讯作者:
    Mutlu GM
Making genomics functional: deciphering the genetics of acute lung injury.
使基因组学发挥作用:破译急性肺损伤的遗传学。
Immediate Effect of Mechanical Ventilation Mode and Sedative Infusion on Measured Diaphragm Thickness.
机械通气模式和镇静输注对测得的隔膜厚度的立即影响。
  • DOI:
    10.1513/annalsats.202111-1280oc
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    8.3
  • 作者:
    Pearson,StevenD;Lin,Julie;Stutz,MatthewR;Lecompte-Osorio,Paola;Pohlman,AnneS;Wolfe,KrystaS;Hall,JesseB;Kress,JohnP;Patel,BhaktiK
  • 通讯作者:
    Patel,BhaktiK
Non-canonical functions of RGS proteins.
  • DOI:
    10.1016/j.cellsig.2010.03.016
  • 发表时间:
    2010-09
  • 期刊:
  • 影响因子:
    4.8
  • 作者:
    Sethakorn N;Yau DM;Dulin NO
  • 通讯作者:
    Dulin NO
HIF-1α induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury.
  • DOI:
    10.7554/elife.77457
  • 发表时间:
    2022-07-13
  • 期刊:
  • 影响因子:
    7.7
  • 作者:
    Woods, Parker S.;Kimmig, Lucas M.;Sun, Kaitlyn A.;Meliton, Angelo Y.;Shamaa, Obada R.;Tian, Yufeng;Cetin-Atalay, Renguel;Sharp, Willard W.;Hamanaka, Robert B.;Mutlu, Goekhan M.
  • 通讯作者:
    Mutlu, Goekhan M.
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Yun Fang其他文献

Yun Fang的其他文献

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{{ truncateString('Yun Fang', 18)}}的其他基金

Precision nanomedicine targeting novel endothelial mechano-sensing mechanisms
针对新型内皮机械传感机制的精密纳米医学
  • 批准号:
    10630052
  • 财政年份:
    2022
  • 资助金额:
    $ 88.92万
  • 项目类别:
Precision nanomedicine targeting novel endothelial mechano-sensing mechanisms
针对新型内皮机械传感机制的精密纳米医学
  • 批准号:
    10354607
  • 财政年份:
    2022
  • 资助金额:
    $ 88.92万
  • 项目类别:
Coronary artery disease locus 1p32.2 and miR92a-PPAP2B signaling in endothelial mechanobiology
内皮力学生物学中的冠状动脉疾病基因座 1p32.2 和 miR92a-PPAP2B 信号传导
  • 批准号:
    10171493
  • 财政年份:
    2017
  • 资助金额:
    $ 88.92万
  • 项目类别:
Spatial Delivery of MicroRNA Inhibitor via Targeted Polyelectrolyte Complex Micelles to Treat Atherosclerosis.
通过靶向聚电解质复合胶束空间递送 MicroRNA 抑制剂来治疗动脉粥样硬化。
  • 批准号:
    10229491
  • 财政年份:
    2017
  • 资助金额:
    $ 88.92万
  • 项目类别:
Coronary artery disease locus 1p32.2 and miR92a-PPAP2B signaling in endothelial mechanobiology
内皮力学生物学中的冠状动脉疾病基因座 1p32.2 和 miR92a-PPAP2B 信号传导
  • 批准号:
    9539874
  • 财政年份:
    2017
  • 资助金额:
    $ 88.92万
  • 项目类别:
Spatial Delivery of MicroRNA Inhibitor via Targeted Polyelectrolyte Complex Micelles to Treat Atherosclerosis.
通过靶向聚电解质复合胶束空间递送 MicroRNA 抑制剂来治疗动脉粥样硬化。
  • 批准号:
    10004707
  • 财政年份:
    2017
  • 资助金额:
    $ 88.92万
  • 项目类别:
miR-10a regulation of regional arterial endothelial phenotypes in atherosclerosis
miR-10a对动脉粥样硬化区域动脉内皮表型的调节
  • 批准号:
    8639625
  • 财政年份:
    2013
  • 资助金额:
    $ 88.92万
  • 项目类别:
miR-10a regulation of regional arterial endothelial phenotypes in atherosclerosis
miR-10a对动脉粥样硬化区域动脉内皮表型的调节
  • 批准号:
    8653985
  • 财政年份:
    2013
  • 资助金额:
    $ 88.92万
  • 项目类别:
miR-10a regulation of regional arterial endothelial phenotypes in atherosclerosis
miR-10a对动脉粥样硬化区域动脉内皮表型的调节
  • 批准号:
    8247722
  • 财政年份:
    2011
  • 资助金额:
    $ 88.92万
  • 项目类别:
miR-10a regulation of regional arterial endothelial phenotypes in atherosclerosis
miR-10a对动脉粥样硬化区域动脉内皮表型的调节
  • 批准号:
    8111489
  • 财政年份:
    2011
  • 资助金额:
    $ 88.92万
  • 项目类别:

相似海外基金

Research Training for Computation and Informatics in Biology and Medicine
生物学和医学计算和信息学研究培训
  • 批准号:
    7625392
  • 财政年份:
    2002
  • 资助金额:
    $ 88.92万
  • 项目类别:
Research Training for Computation and Informatics in Biology and Medicine
生物学和医学计算和信息学研究培训
  • 批准号:
    7557935
  • 财政年份:
    2002
  • 资助金额:
    $ 88.92万
  • 项目类别:
NHLBI RESPIRATORY BIOLOGY RESEARCH TRAINING GRANT
NHLBI 呼吸生物学研究培训补助金
  • 批准号:
    2857736
  • 财政年份:
    1998
  • 资助金额:
    $ 88.92万
  • 项目类别:
NHLBI RESPIRATORY BIOLOGY RESEARCH TRAINING GRANT
NHLBI 呼吸生物学研究培训补助金
  • 批准号:
    6343463
  • 财政年份:
    1998
  • 资助金额:
    $ 88.92万
  • 项目类别:
NHLBI RESPIRATORY BIOLOGY RESEARCH TRAINING GRANT
NHLBI 呼吸生物学研究培训补助金
  • 批准号:
    2547159
  • 财政年份:
    1998
  • 资助金额:
    $ 88.92万
  • 项目类别:
NHLBI RESPIRATORY BIOLOGY RESEARCH TRAINING GRANT
NHLBI 呼吸生物学研究培训补助金
  • 批准号:
    6490675
  • 财政年份:
    1998
  • 资助金额:
    $ 88.92万
  • 项目类别:
NHLBI RESPIRATORY BIOLOGY RESEARCH TRAINING GRANT
NHLBI 呼吸生物学研究培训补助金
  • 批准号:
    6139102
  • 财政年份:
    1998
  • 资助金额:
    $ 88.92万
  • 项目类别:
RESEARCH TRAINING IN RESPIRATORY BIOLOGY
呼吸生物学研究培训
  • 批准号:
    2212589
  • 财政年份:
    1985
  • 资助金额:
    $ 88.92万
  • 项目类别:
RESEARCH TRAINING IN RESPIRATORY BIOLOGY
呼吸生物学研究培训
  • 批准号:
    6343381
  • 财政年份:
    1985
  • 资助金额:
    $ 88.92万
  • 项目类别:
RESEARCH TRAINING IN RESPIRATORY BIOLOGY
呼吸生物学研究培训
  • 批准号:
    6490494
  • 财政年份:
    1985
  • 资助金额:
    $ 88.92万
  • 项目类别:
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