Research training in respiratory biology

呼吸生物学研究培训

基本信息

批准号：
10696963
负责人：
Yun Fang
金额：
$ 88.92万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-08-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10696963
关键词：
Biology Research Training respiratory

项目摘要

PROJECT SUMMARY The objective of our competing renewal application for the Univ of Chicago Research Training Program in Respiratory Biology is to prepare young scientists to pursue research careers addressing mechanisms and treatment of human disease, with a focus on respiratory pathobiology. The cohesiveness of this interdiscipli- nary Program stems from the highly collaborative nature of our 38 well-funded faculty in 7 departments and the Institute for Molecular Engineering at the Univ of Chicago in multiple areas of concentration. Studies in Asthma and Airway Physiology/Immunology continue to focus on airway inflammation, airway smooth muscle and epithelial structure and function, B-cell and T-cell activation, asthma genetics, and clinical investigation. These complement programs of Studies in Lung Immunology and Transplantation that focus on cellular and molecular mechanisms underlying transplantation immunology and their translational applications to patients, and translational Studies in Interstitial Lung Diseases that draw on one of the largest dedicated clinics in the Midwest. A Concentration in Airway and Mucosal Microbiome adds this critically important emerging research direction to the asthma and ILD programs. Studies in Critical Illness and Acute Lung Injury continue to address subcellular determinants of oxygen sensing and consumption, cellular responses to hypoxia, membrane biology, endothelial and epithelial barrier function, and bedside translations to patients with sepsis, cardiopulmonary arrest, and sleep disturbance. Complementing these are cross-cutting Studies in Genetics and Epigenetics and Concentration in Health Studies and Ethics. The Program Directors are Anne I. Sperling, PhD and Julian Solway, MD, with Associate Director Steven White, MD (Mentorship and Career Development). Christopher Olopade, MD, MPH chairs a Diversity Committee. Internal and External Advisors provide oversight and continuity of review, and an Admissions/Steering Committee reviews trainee progress. We request funding for 10 post-doctoral trainees. PhD, MD, and MD/PhD trainees are enrolled and trained together. Collaboration of basic and clinical scientists on research further enhances the integrative and translational nature of our program. All fellows perform full-time research for at least 2 years, and MD fellows will devote not more than 10% time to clinical training while supported by this Program. Training consists of 5 major components: a Research Project performed under the direct supervision of faculty co-mentors; a Core Curriculum of robust seminar series and courses with additional, tailored formal coursework; Core Competencies that includes scientific communication, grant writing, and mentoring; Multidisciplinary Research; and Individualized Career Development Planning. Prior trainees from this Program have developed successful independent research careers in large proportion. Refinements presented here should further enhance the likelihood for success of future trainees.

项目摘要我们在芝加哥大学研究培训计划中竞争续订申请的目的呼吸生物学是为年轻科学家做好准备，从而从事研究事业，以解决机制和治疗人类疾病，重点是呼吸道病理学。这个跨学科的凝聚力 Nary计划源于我们在7个部门的38个资助良好的教师的高度协作性质，芝加哥大学分子工程研究所在多个集中度领域。研究哮喘气道生理/免疫学继续专注于气道炎症，气道平滑肌和上皮结构和功能，B细胞和T细胞激活，哮喘遗传学以及临床研究。这些肺部免疫学和移植研究的补充计划，重点是细胞和分子移植免疫学及其对患者的翻译应用的机制，以及在肺部肺部疾病的转化研究，该研究吸引了最大的专用诊所之一中西部。气道和粘膜微生物组的浓度增加了这一至关重要的新兴研究指导哮喘和ILD计划。关于重症疾病和急性肺损伤的研究继续解决氧气感应和消耗的亚细胞决定因素，对缺氧的细胞反应，膜生物学，内皮和上皮屏障功能以及败血症患者的床头翻译，心肺逮捕和睡眠障碍。补充这些是遗传学的横切研究以及健康研究和伦理学的表观遗传学和集中度。计划主管是Anne I. Sperling，博士学位和医学博士Julian Solway，医学博士史蒂文·怀特（Steven White）（指导和职业发展）。医学博士Christopher Olopade，MPH主席多元化委员会。内部和外部顾问提供监督和审查的连续性，以及招生/指导委员会审查培训生的进度。我们要求资金对于10名博士后学员。博士学位，医学博士和医学博士/博士学位学员将一起入学和培训。合作研究基础和临床科学家的研究进一步增强了我们的综合性和翻译性质程序。所有研究员至少进行全日制研究至少两年，而MD研究员的奉献将不超过在此计划的支持下，有10％的临床培训时间。培训由5个主要组成部分组成：一个研究项目在教职员工的直接监督下进行；强大的核心课程研讨会系列和课程，包括其他量身定制的正式课程；包括科学交流，授予写作和指导；多学科研究；和个性化的职业发展计划。该计划的先前学员已经开发了成功的独立研究很大程度上的职业。这里提出的改进应进一步增强成功的可能性未来的学员。