2023 Cellular and Molecular Mechanisms of Toxicity Gordon Research Conference and Seminar

摘要 在毒理学研究的许多领域，包括环境科学和 制药和消费品开发是科学进步的关键，因为科学家们 包括学术界、私营企业和政府在内的许多专业部门都在努力解决关键的公共问题， 健康问题毒性的细胞和分子机制（CMMT）戈登研究会议 (GRC)拥有丰富的历史，介绍了最新的未发表的创新，在机械毒理学研究 在一个大学的环境中。多年来，CMMT GRC的一个重点是培养一个强大的 社区意识，鼓励科学交流，网络，和整个职业发展 会议周，这已被称为结转到与会者的职业生涯。经过两年的延期 由于新型冠状病毒疫情，2023年为期一周的节目在"现代化"的主题下进行了更新 机制毒理学研究方法"，旨在突出整个 毒理学的各个专业部门。主席们与指导委员会合作， 一组讨论领导人和发言人，代表来自世界各地的广泛利益和科学背景 地球仪。科学会议，敏锐地集中在机制毒理学，涵盖广泛的主题，包括 功能基因组学，人工智能，环境毒物代谢，现代发育 毒性测试，细胞微环境对毒性反应的影响，以及新方法的整合 多个重点领域的风险评估方法，包括混合物、神经毒性和新的治疗方法 方式。鼓励与会者提交每日海报会议的摘要， 介绍将被选中。该计划还将设有一个电源小时，作为一个地点，以解决 妇女在科学领域面临的挑战，并促进关于多样性的讨论。它将首次集中于 挑战的妇女与交叉身份，并将领导积极毒理学家谁也知道 该领域的倡导者和毒理学特别兴趣小组，毒理学家和 盟友为了进一步增加多样性，主席将积极招募来自几个特殊利益集团的与会者， 毒理学学会的各个团体。促进受训人员的发展仍然是该方案的一个中心重点， CMMT GRC和2023年会议将再次包括为期1.5天的戈登研究研讨会（GRS）。档案处 计划将包括一个关于转化毒理学的主题演讲，一个关于创建一个 有效的数字展示，以及几次最新的口头和海报展示机会。见习 将继续发展，包括从GRS挑选的2名受训人员，以及来自 在美国和国外，在GRC计划的早期职业调查会议。尽管与COVID相关 延误，GRC和GRS主席，沿着讨论领导人和发言者渴望提供一个令人兴奋的， 2023年的尖端计划，延续了科学界在前几年形成的长期传统。

ABSTRACT Collaboration across the many areas of toxicology research including the environmental sciences and pharmaceutical and consumer product development, is critical for scientific advancement as scientists across many professional sectors including academia, private industry and government strive to solve crucial public health problems. The Cellular and Molecular Mechanisms of Toxicity (CMMT) Gordon Research Conference (GRC) boasts a rich history of presenting the latest unpublished innovations in mechanistic toxicology research within a collegial environment. A key focus of the CMMT GRC throughout the years has been to foster a strong sense of community by encouraging scientific exchange, networking, and career development throughout the conference week, which has been known to carry forward into attendees' careers. After a 2 year postponement due to the COVID pandemic, the 2023 week-long program has been refreshed under the theme “Modernized Approaches to Mechanistic Toxicology Investigations” and aims to highlight scientific advancements across the various professional sectors of toxicology. Working with a Steering Committee, the Chairs assembled a diverse group of Discussion Leaders and Speakers representing broad interests and scientific backgrounds from across the globe. The scientific sessions, keenly focused on mechanistic toxicology, cover broad topics including functional genomics, artificial intelligence, environmental toxicant metabolism, modernized developmental toxicity testing, impact of the cellular microenvironment on toxic responses, and integration of new approach methodologies in risk assessment for multiple focus areas including mixtures, neurotoxicity, and new therapeutic modalities. Attendees are encouraged to submit abstracts for daily poster sessions from which late-breaking oral presentations will be selected. The program will also feature a Power Hour, which serves as a venue to address challenges faced by women in science and promote discussions on diversity. For the first time, it will focus on challenges for women with intersectional identities and will be led by active toxicologists who are also known advocates in the field and leaders in the Society of Toxicology Special Interest Group, Out Toxicologists and Allies. To further increase diversity, the Chairs will proactively recruit attendees from several special interest groups across toxicological societies. Fostering development of trainees continues to be a central focus of the CMMT GRC and the 2023 conference will again include a 1.5 day Gordon Research Seminar (GRS). The GRS program will include a keynote session on translational toxicology, a career development session on creating an effective digital presence, and several opportunities for late-breaking oral and poster presentations. Trainee development will continue by inclusion of 2 trainees selected from the GRS, alongside emerging stars from across the U.S. and abroad, for an early career investigator session in the GRC program. Despite COVID-related delays, the GRC and GRS Chairs, along with Discussion Leaders and Speakers are eager to provide an exciting, cutting edge program in 2023 that continues the long-held tradition of scientific community forged in prior years.