2023 Cellular and Molecular Mechanisms of Toxicity Gordon Research Conference and Seminar

摘要 跨毒理学研究的许多领域的合作，包括环境科学和 制药和消费品开发，是科学进步的关键，因为科学家们 包括学术界、私营企业和政府在内的许多专业部门都在努力解决关键的公共 健康问题。毒性的细胞和分子机制(CMMT)戈登研究会议 (GRC)拥有丰富的历史，展示了机械毒理学研究中最新的未发表的创新 在合议制的环境中。多年来，CMMT GRC的一个关键重点一直是培育强大的 通过鼓励科学交流、网络和职业发展，形成社区意识 会议周，众所周知，这将延续到与会者的职业生涯中。在两年的延期之后 由于新冠肺炎的流行，2023年为期一周的计划已更新为“现代化”的主题 《机械性毒理学研究的方法》，旨在突出 毒物学的各个专业部门。与指导委员会合作，主席们组装了不同的 代表来自世界各地的广泛兴趣和科学背景的讨论领袖和演讲者小组 环球网。科学会议的重点是机械毒理学，涵盖了广泛的主题，包括 功能基因组学、人工智能、环境毒物代谢、现代化发展 毒性测试，细胞微环境对毒性反应的影响，以及新方法的集成 多焦点领域风险评估方法，包括混合物、神经毒性和新疗法 医疗模式。鼓励与会者提交每日海报会议的摘要，其中最新的口头发言 将选择演示文稿。该计划还将以Power Hour为特色，作为演讲的场所 妇女在科学领域面临的挑战，并促进关于多样性的讨论。它将首次将重点放在 具有跨部门身份的女性面临的挑战，将由活跃的毒物学家领导，他们也是众所周知的 该领域的倡导者和毒理学学会特别兴趣小组的领导人，我们的毒理学家和 盟友。为了进一步增加多样性，主席将主动招募来自几个特殊利益集团的与会者。 毒物学学会中的各个群体。促进受训人员的发展仍然是 CMMT GRC和2023年会议将再次包括为期1.5天的戈登研究研讨会(GRS)。《全球资源报告》 该计划将包括关于翻译毒理学的主旨会议，关于创建 有效的数字呈现，以及几个最新的口头和海报演示机会。实习生 发展将继续，包括从GRS挑选的2名实习生，以及来自 在美国和海外，参加GRC项目的早期职业调查员会议。尽管与COVID有关 延迟，GRC和GRS主席以及讨论领导人和演讲者渴望提供一个令人兴奋的， 2023年的尖端计划，延续了前几年形成的科学界的长期传统。

ABSTRACT Collaboration across the many areas of toxicology research including the environmental sciences and pharmaceutical and consumer product development, is critical for scientific advancement as scientists across many professional sectors including academia, private industry and government strive to solve crucial public health problems. The Cellular and Molecular Mechanisms of Toxicity (CMMT) Gordon Research Conference (GRC) boasts a rich history of presenting the latest unpublished innovations in mechanistic toxicology research within a collegial environment. A key focus of the CMMT GRC throughout the years has been to foster a strong sense of community by encouraging scientific exchange, networking, and career development throughout the conference week, which has been known to carry forward into attendees' careers. After a 2 year postponement due to the COVID pandemic, the 2023 week-long program has been refreshed under the theme “Modernized Approaches to Mechanistic Toxicology Investigations” and aims to highlight scientific advancements across the various professional sectors of toxicology. Working with a Steering Committee, the Chairs assembled a diverse group of Discussion Leaders and Speakers representing broad interests and scientific backgrounds from across the globe. The scientific sessions, keenly focused on mechanistic toxicology, cover broad topics including functional genomics, artificial intelligence, environmental toxicant metabolism, modernized developmental toxicity testing, impact of the cellular microenvironment on toxic responses, and integration of new approach methodologies in risk assessment for multiple focus areas including mixtures, neurotoxicity, and new therapeutic modalities. Attendees are encouraged to submit abstracts for daily poster sessions from which late-breaking oral presentations will be selected. The program will also feature a Power Hour, which serves as a venue to address challenges faced by women in science and promote discussions on diversity. For the first time, it will focus on challenges for women with intersectional identities and will be led by active toxicologists who are also known advocates in the field and leaders in the Society of Toxicology Special Interest Group, Out Toxicologists and Allies. To further increase diversity, the Chairs will proactively recruit attendees from several special interest groups across toxicological societies. Fostering development of trainees continues to be a central focus of the CMMT GRC and the 2023 conference will again include a 1.5 day Gordon Research Seminar (GRS). The GRS program will include a keynote session on translational toxicology, a career development session on creating an effective digital presence, and several opportunities for late-breaking oral and poster presentations. Trainee development will continue by inclusion of 2 trainees selected from the GRS, alongside emerging stars from across the U.S. and abroad, for an early career investigator session in the GRC program. Despite COVID-related delays, the GRC and GRS Chairs, along with Discussion Leaders and Speakers are eager to provide an exciting, cutting edge program in 2023 that continues the long-held tradition of scientific community forged in prior years.