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Prevalence and Clinical Correlates of Thirdhand Smoke Exposure in a Pediatric Patient Population

儿科患者群体中三手烟暴露的患病率和临床相关性

基本信息

批准号：
10673044
负责人：
E. Melinda Mahabee-Gittens
金额：
$ 52.3万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10673044
关键词：
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone 8-hydroxy-2&apos -deoxyguanosine Accident and Emergency department Accidents Affect Age Air Animals Asthma Biochemical Biological Biological Markers Carpet Chemicals Child Child Care Childhood Cigarette Clinical Cotinine DNA DNA Damage Disease Dust Environment Exposure to Foundations Frequencies Furniture Gases Hand Health Health Care Visit Home Home visitation Hospitalization Housing Human Impairment In Vitro Inflammation Inflammatory Isoprostanes Laboratories Life Link Lipids Longitudinal cohort study Mus Nicotine Nitrosamines Oxidants Oxidative Stress Oxides Parents Pattern Phase Pollution Prevalence Proteins Reaction Reporting Research Respiratory Signs and Symptoms Respiratory physiology Sampling Smoke Smoker Smoking Source Surface TNF gene Techniques Time Tobacco Tobacco Smoke Pollution Tobacco smoke Tobacco use Toddler Toy Validation carcinogenicity clinical effect clinical risk cytokine demographics design environmental tobacco smoke environmental tobacco smoke exposure innovation insight non-smoker oxidation patient population pediatric emergency pediatric patients pollutant prospective pulmonary function repository respiratory response response biomarker screening thirdhand smoke tobacco smoke exposure urinary

项目摘要

PROJECT SUMMARY Thirdhand smoke (THS) is the persistent toxic residue of tobacco smoke pollutants that attaches to surfaces, remains in dust, and becomes embedded in environments where secondhand smoke (SHS) has been released into the air. Even when parents are diligent in attempting to shield their children from tobacco smoke, exposure to SHS (SHSe) and THS (THSe) still occurs. Residue from previously smoked tobacco at home or in a car creates a pervasive reservoir of tobacco smoke pollutants that are within reach of a child's hand such as on carpets, furniture, clothes, and toys, and breathed in dust. Homes of smokers become reservoirs of these pollutants that persist for years, become more toxic with age, and are later reemitted into the gas phase, or react with common ambient oxidants and other environmental compounds to yield secondary pollutants such as carcinogenic tobacco-specific nitrosamines. The clinical effects of THSe are unknown because prior research has examined children exposed to both SHS and THS. Studies exclusively focusing on THSe are needed. Thus, we have conducted in-vitro, animal, and pilot pediatric studies that demonstrate that THSe is associated with high levels of inflammatory cytokines, respiratory illnesses, and oxidative stress including DNA damage, in mice. We have found even in the presence of smoking bans, children still have high levels of THS pollution on their hands and that nonsmokers' homes have high THS pollution levels. However, in the absence of large-scale, rigorous human studies, conclusions about the clinical effects of THSe cannot be made. Thus, we propose an innovative prospective longitudinal cohort study that will move the field forward and away from the laboratory to a pediatric clinical setting as the first pediatric study to use biochemical validation to identify children exposed to THS-only over time. We will screen 1000 children from the pediatric emergency department, a setting which cares for children with varying tobacco smoke exposure (TSE) levels and illnesses. Using strict screening and chemical analysis techniques, we will identify and compare children that comprise three distinct TSE groups: 1) THSe only group: live with nonsmokers, no reported SHSe, confirmed negative/low levels of SHSe, elevated levels of THSe; 2) Mixed SHSe+THSe group: live with smokers, reported SHSe, confirmed moderate/high levels of SHSe, high levels of THSe; and 3) No TSE group: live with nonsmokers, no reported SHSe, confirmed negative levels of SHSe and THSe. The prevalence and levels of THSe, demographics, and exposure and illness patterns of these groups will be compared over time. Next, we will disentangle which environmental sources contribute to THSe levels and the association between THSe and inflammatory (i.e., cytokines) and oxidative (i.e., DNA, lipid, protein oxidation) biomarkers and TSE- related clinical illnesses. Results will provide unique insights into how THSe and sources of tobacco smoke pollution affect the inflammatory, oxidative, and clinical responses in children. The potential impact of these findings is substantial as currently, the level of clinical risk attributable to THSe is unknown.

项目总结第三手烟(THS)是烟草烟雾污染物附着到表面，留在灰尘中，并嵌入二手烟(SHS)具有被释放到空中。即使父母努力让他们的孩子远离烟草吸烟、暴露于SHS(SHSE)和THS(THSE)的情况仍然存在。以前吸烟的烟草残留物在在家里或在车里会产生无处不在的烟草烟雾污染物，这些污染物是儿童触手可及的手放在地毯、家具、衣服和玩具上，呼吸在灰尘中。吸烟者的家变成了这些污染物的蓄水池持续多年，随着时间的推移变得更加有毒，后来重新排放到气相，或与常见的环境氧化剂和其他环境化合物反应生成次生物质致癌烟草特有的亚硝胺等污染物。这些药物的临床疗效尚不清楚。因为之前的研究调查了同时接触SHS和THS的儿童。专门关注以下方面的研究这些都是必需的。因此，我们进行了体外、动物和试点儿科研究，证明了这与高水平的炎性细胞因子、呼吸系统疾病和氧化应激有关。包括对小鼠的DNA损伤。我们发现，即使在禁烟的情况下，儿童仍然有很高的他们手上的THS污染水平很高，不吸烟者的家里THS污染水平很高。然而，在缺乏大规模、严谨的人体研究的情况下，无法得出关于这类药物临床效果的结论。制造。因此，我们提出了一项创新的前瞻性纵向队列研究，将推动该领域的发展。从实验室到儿科临床环境作为第一个使用生化的儿科研究验证以识别暴露于THS的儿童-仅随着时间的推移。我们将对1000名儿童进行儿童筛查急诊室，一个照顾不同烟草烟雾暴露(TSE)水平的儿童的环境和疾病。使用严格的筛查和化学分析技术，我们将识别和比较儿童包括三个不同的TSE组：1)仅此组：与非吸烟者生活在一起，无报道的SHSE，确认SHSE阴性/低水平，THSE水平升高；2)混合HSE+THSE组：生活在一起据报道，吸烟者确认了中/高水平的SHSE，即高水平的SHSE；3)没有TSE组：与非吸烟者生活在一起，没有SHSE报告，证实SHSE和THSE水平为负值。流行率和随着时间的推移，将对这些群体的TSE水平、人口统计学以及暴露和疾病模式进行比较。接下来，我们将解开哪些环境来源对这些水平有贡献，以及它们之间的联系这与炎症性(即细胞因子)和氧化性(即DNA、脂肪、蛋白质氧化)生物标志物和TSE- 相关的临床疾病。结果将为烟草烟雾的产生和来源提供独特的见解。污染会影响儿童的炎症、氧化和临床反应。这些措施的潜在影响研究结果是实质性的，因为目前，可归因于该疾病的临床风险水平尚不清楚。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Neonatal AVPR1a Methylation and In-Utero Exposure to Maternal Smoking.

DOI：
10.3390/toxics11100855
发表时间：
2023-10-13
期刊：
Toxics
影响因子：
4.6
作者：
Nidey N;Bowers K;Ding L;Ji H;Ammerman RT;Yolton K;Mahabee-Gittens EM;Folger AT
通讯作者：
Folger AT

Smoking Cessation Level of Contemplation in the Pediatric Emergency Department.

儿科急诊室的戒烟水平。