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The neural mechanisms of risk for alcohol use disorder among college students

大学生酒精使用障碍风险的神经机制

基本信息

批准号：
10676549
负责人：
Amanda L Elton
金额：
$ 15.4万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-08 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10676549
关键词：
21 year old Adolescent Adult Affect Affective Age Alcohol abuse Alcohol consumption Alcoholism Analysis of Covariance Applications Grants Behavior Behavioral Biological Markers Brain Brain region Characteristics Child Child Abuse and Neglect Childhood Cognitive Complex Data Data Analyses Decision Making Development Disease Elderly Enrollment Environmental Risk Factor Epidemiology Equation Family history of Female Foundations Functional Magnetic Resonance Imaging Future Genetic Genetic Predisposition to Disease Genetic Risk Growth Heritability Impulsive Behavior Impulsivity Incidence Individual Individual Differences Investigation Knowledge Link Measures Mediating Mediator of activation protein Mentors Methodology Modeling Motor Neurobiology Neurosciences Participant Pathologic Pathway interactions Patient Self-Report Pattern Performance Phenotype Predisposition Prevention strategy Publications Recording of previous events Reporting Research Research Project Grants Rewards Risk Risk Factors Role Sex Differences Signal Transduction Stress Surveys Testing Time TimeLine Training addiction alcohol misuse alcohol risk alcohol use disorder base behavior measurement cognitive neuroscience design discounting disorder risk drinking drinking behavior early life stress emerging adult endophenotype experience follow-up functional MRI scan longitudinal analysis male neglect neural network neuroimaging neuroimaging marker neuromechanism pediatric trauma population based recruit relating to nervous system research study response sex support network symposium training project underage drinking university student

项目摘要

PROJECT SUMMARY/ABSTRACT Individuals with a history of childhood trauma are at an increased risk of developing an alcohol use disorder (AUD), a susceptibility that is further enhanced if they have a family history of this disorder. In fact, approximately 50% of the risk for developing an alcohol use disorder (AUD) is driven by genetic factors. Thus, evidence suggests that both genetic and environmental risk factors contribute to AUD and that these factors likely exert combined effects. However, the neural mechanisms by which these risk factors contribute to the development of AUD are not yet understood. Research in individuals with a family history of AUD suggests that this genetic predisposition produces increased behavioral impulsivity. Previous research in victims of childhood maltreatment has likewise identified cognitive and affective consequences of childhood stress, including increased impulsivity. It is noteworthy that impulsive behavior is not only characteristic of individuals with a current AUD, but is also a predictor later life alcohol use among adolescents, suggesting these behaviors precede the development of AUD. This proposed training and research study are built on the hypothesis that impulsivity functions as an intermediate phenotype that mediates the relationship between genetic and environmental risk factors for AUD and problem drinking. The training project will focus on two domains of impulsivity – discounting of delayed rewards and response inhibition – based on strong evidence supporting their link to both AUD and its risk factors. The first Aim will include a neuroimaging investigation of the these two tasks of impulsivity and an examination of the large-scale neural network correlates of risk factors for AUD. Longitudinal analyses (Aim 2) will examine the predictive relationship between neural measures of impulsivity on these tasks and changes in alcohol consumption over a three year follow-up timeline. Finally, Aim 3 is dedicated to examining the sex-dependent neural alterations associated with risk for AUD and well as sex-dependent relationships between the brain and alcohol use trajectories. The candidate’s prior training in the neurodevelopmental consequences of childhood trauma, cognitive neuroscience of addiction, sex differences, advanced statistical approaches, and neuroimaging methodologies provide a strong foundation for the proposed research project. The proposed training experiences will fill additional gaps through a combination of mentoring, didactic coursework, seminars, and conferences. The training plan is particularly tailored to provide additional support in alcoholism research and provides an extension into the study of addiction genetics. The training experience will be led by Dr. Charlotte Boettiger, an expert in behavioral and neuroimaging biomarkers of addiction, and supported by co-mentors Dr. Fulton Crews, an expert in the neurobiology of AUD, and Dr. Kirk Wilhelmsen, an expert in addiction genetics. The completion of this training will provide a strong foundation enabling the candidate to pursue independent research and will provide adequate knowledge, publications, and pilot data to be competitive for future grant applications focused on elucidating the neural basis of risk for AUD.

项目总结/文摘