NRF2-ACSS2 Axis in Alcohol-induced Metabolic Reprogramming and Esophageal Pathology

NRF2-ACSS2 轴在酒精诱导的代谢重编程和食管病理学中的作用

基本信息

项目摘要

PROJECT SUMMARY This multiple-PI R01 proposal is designed to incorporate both in vitro and in vivo approaches to elucidate the role of the NRF2-ACSS2 axis in alcohol-induced metabolic reprogramming and esophageal pathology. We hypothesize that the NRF2-ACSS2 axis mediates metabolic reprogramming in alcohol-associated esophageal pathology. We will test this hypothesis using human cells and genetically modified mice through three independent and complementary Specific Aims. In Aim 1, we will characterize the role of NRF2-ACSS2 axis in mediating alcohol-induced metabolic reprogramming in human esophageal squamous epithelial cells in vitro. In Aim 2, we will validate the role of the NRF2-ACSS2 axis in mediating alcohol-induced metabolic reprogramming in mouse esophagus in vivo. In Aim 3, we will examine the inhibitory effects of NRF2 and ACSS2 inhibitors on alcohol-induced metabolic reprogramming and esophageal pathology in vivo. If the hypothesis proved to be true, these studies will lay down a solid mechanistic foundation for NRF2/ACSS2 inhibition as a novel mechanism-based preventive measure against alcohol-associated esophageal pathology in the future.
项目总结

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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XIAOXIN Luke CHEN其他文献

XIAOXIN Luke CHEN的其他文献

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{{ truncateString('XIAOXIN Luke CHEN', 18)}}的其他基金

NRF2-ACSS2 Axis in Alcohol-induced Metabolic Reprogramming and Esophageal Pathology
NRF2-ACSS2 轴在酒精诱导的代谢重编程和食管病理学中的作用
  • 批准号:
    10810414
  • 财政年份:
    2022
  • 资助金额:
    $ 61.69万
  • 项目类别:
Mechanisms and Targeted Therapy of NRF2-high Esophageal Squamous Cell Carcinoma
NRF2高食管鳞癌的机制及靶向治疗
  • 批准号:
    10407469
  • 财政年份:
    2020
  • 资助金额:
    $ 61.69万
  • 项目类别:
Mechanisms and Targeted Therapy of NRF2-high Esophageal Squamous Cell Carcinoma
NRF2高食管鳞癌的机制及靶向治疗
  • 批准号:
    10530998
  • 财政年份:
    2020
  • 资助金额:
    $ 61.69万
  • 项目类别:
Mechanisms and Targeted Therapy of NRF2-high Esophageal Squamous Cell Carcinoma
NRF2高食管鳞癌的机制及靶向治疗
  • 批准号:
    10851493
  • 财政年份:
    2020
  • 资助金额:
    $ 61.69万
  • 项目类别:
Mechanisms and Targeted Therapy of NRF2-high Esophageal Squamous Cell Carcinoma
NRF2高食管鳞癌的机制及靶向治疗
  • 批准号:
    10850620
  • 财政年份:
    2020
  • 资助金额:
    $ 61.69万
  • 项目类别:
NOTCH-PAX9 signaling in alcohol-induced esophageal injury
NOTCH-PAX9 信号在酒精性食管损伤中的作用
  • 批准号:
    10023247
  • 财政年份:
    2019
  • 资助金额:
    $ 61.69万
  • 项目类别:
Research Infrastructure Core (RIC)
研究基础设施核心 (RIC)
  • 批准号:
    9977710
  • 财政年份:
    2017
  • 资助金额:
    $ 61.69万
  • 项目类别:
Research Infrastructure Core (RIC)
研究基础设施核心 (RIC)
  • 批准号:
    10204733
  • 财政年份:
    2017
  • 资助金额:
    $ 61.69万
  • 项目类别:
Pilot Project 2: Nrf2 Activation in Esophageal Squamous Cell Carcinogenesis In Vivo
试点项目 2:Nrf2 激活在食管鳞状细胞体内癌变过程中的作用
  • 批准号:
    9050352
  • 财政年份:
    2010
  • 资助金额:
    $ 61.69万
  • 项目类别:
Resource/Infrastructure Development Core
资源/基础设施开发核心
  • 批准号:
    8068492
  • 财政年份:
    2010
  • 资助金额:
    $ 61.69万
  • 项目类别:

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  • 批准号:
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