NRF2-ACSS2 Axis in Alcohol-induced Metabolic Reprogramming and Esophageal Pathology
NRF2-ACSS2 轴在酒精诱导的代谢重编程和食管病理学中的作用
基本信息
- 批准号:10673201
- 负责人:
- 金额:$ 61.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-01 至 2027-07-31
- 项目状态:未结题
- 来源:
- 关键词:AcetaldehydeAcetatesAcetyl Coenzyme AAlcohol consumptionAlcoholsAnimal ModelAutoradiographyBiological AssayCarbonCarcinogensCell ProliferationCell modelCellsCitric Acid CycleClinicalCoenzyme A LigasesCultured CellsDNADataDietDoseDrug Metabolic DetoxicationEpithelial CellsEsophageal DiseasesEsophageal Squamous CellEsophageal Squamous Cell CarcinomaEsophagusEthanolEthanol MetabolismFamily memberFoundationsFutureGastroesophageal reflux diseaseGene ExpressionGenesGenetic TranscriptionGenus HippocampusHistone AcetylationHumanHyperactivityIn VitroLabelLinkLipidsLiquid substanceMalignant NeoplasmsMalignant neoplasm of esophagusMeasuresMediatingMembrane Transport ProteinsMetabolicMetabolismModelingMolecularMusNeoplasm MetastasisPET/CT scanPathologyPhasePhenotypePreventivePreventive measureProductionProteinsRegulationRisk FactorsRoleSignal TransductionSolidSourceTestingTimeTissuesTranslatingWorkalcohol exposurealcohol preventioncancer celldensitydesignin vivoinhibitorknock-downlipid biosynthesismetabolomicsnovelnuclear factor-erythroid 2stable isotopetranscription factortumor progressionuptake
项目摘要
PROJECT SUMMARY
This multiple-PI R01 proposal is designed to incorporate both in vitro and in vivo approaches to elucidate the
role of the NRF2-ACSS2 axis in alcohol-induced metabolic reprogramming and esophageal pathology. We
hypothesize that the NRF2-ACSS2 axis mediates metabolic reprogramming in alcohol-associated esophageal
pathology. We will test this hypothesis using human cells and genetically modified mice through three
independent and complementary Specific Aims. In Aim 1, we will characterize the role of NRF2-ACSS2 axis in
mediating alcohol-induced metabolic reprogramming in human esophageal squamous epithelial cells in vitro. In
Aim 2, we will validate the role of the NRF2-ACSS2 axis in mediating alcohol-induced metabolic
reprogramming in mouse esophagus in vivo. In Aim 3, we will examine the inhibitory effects of NRF2 and
ACSS2 inhibitors on alcohol-induced metabolic reprogramming and esophageal pathology in vivo. If the
hypothesis proved to be true, these studies will lay down a solid mechanistic foundation for NRF2/ACSS2
inhibition as a novel mechanism-based preventive measure against alcohol-associated esophageal pathology
in the future.
项目总结
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('XIAOXIN Luke CHEN', 18)}}的其他基金
NRF2-ACSS2 Axis in Alcohol-induced Metabolic Reprogramming and Esophageal Pathology
NRF2-ACSS2 轴在酒精诱导的代谢重编程和食管病理学中的作用
- 批准号:
10810414 - 财政年份:2022
- 资助金额:
$ 61.69万 - 项目类别:
Mechanisms and Targeted Therapy of NRF2-high Esophageal Squamous Cell Carcinoma
NRF2高食管鳞癌的机制及靶向治疗
- 批准号:
10407469 - 财政年份:2020
- 资助金额:
$ 61.69万 - 项目类别:
Mechanisms and Targeted Therapy of NRF2-high Esophageal Squamous Cell Carcinoma
NRF2高食管鳞癌的机制及靶向治疗
- 批准号:
10530998 - 财政年份:2020
- 资助金额:
$ 61.69万 - 项目类别:
Mechanisms and Targeted Therapy of NRF2-high Esophageal Squamous Cell Carcinoma
NRF2高食管鳞癌的机制及靶向治疗
- 批准号:
10851493 - 财政年份:2020
- 资助金额:
$ 61.69万 - 项目类别:
Mechanisms and Targeted Therapy of NRF2-high Esophageal Squamous Cell Carcinoma
NRF2高食管鳞癌的机制及靶向治疗
- 批准号:
10850620 - 财政年份:2020
- 资助金额:
$ 61.69万 - 项目类别:
NOTCH-PAX9 signaling in alcohol-induced esophageal injury
NOTCH-PAX9 信号在酒精性食管损伤中的作用
- 批准号:
10023247 - 财政年份:2019
- 资助金额:
$ 61.69万 - 项目类别:
Pilot Project 2: Nrf2 Activation in Esophageal Squamous Cell Carcinogenesis In Vivo
试点项目 2:Nrf2 激活在食管鳞状细胞体内癌变过程中的作用
- 批准号:
9050352 - 财政年份:2010
- 资助金额:
$ 61.69万 - 项目类别:
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