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NOTCH-PAX9 signaling in alcohol-induced esophageal injury

NOTCH-PAX9 signaling in alcohol-induced esophageal injury
NOTCH-PAX9 信号在酒精性食管损伤中的作用
批准号：
10023247
负责人：
XIAOXIN Luke CHEN
金额：
$21.28万
依托单位：
NORTH CAROLINA CENTRAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
项目状态：
已结题
起止时间：
2019-09-25 至 2022-08-31
来源：
https://reporter.nih.gov/project-details/10023247
关键词：
AdultAffectAlcohol consumptionAlcoholsBinding SitesCancer EtiologyCarcinogensCell Differentiation processCell NucleusCell ProliferationCell modelCellsCessation of lifeChIP-seqChemicalsCleaved cellDataDietDoseDown-RegulationES01Embryonic DevelopmentEpithelialEpithelial CellsEpitheliumEsophageal DiseasesEsophageal Squamous CellEsophageal injuryEsophagusEthanolExposure toFoundationsFutureGastroesophageal reflux diseaseGene ExpressionGene Expression ProfileGenesGenetic TranscriptionHistopathologyHumanIn VitroKnockout MiceLigandsLiquid substanceMalignant NeoplasmsMalignant neoplasm of esophagusMeasuresMolecularMusNOTCH1 genePhenotypePlayPopulationPreventive measureRefluxRisk FactorsRoleSignal PathwaySignal TransductionSolidSquamous CellSquamous EpitheliumSymptomsTestingTimeTissuesWestern Blottingalcohol effectalcohol exposurebasecarcinogenesisdesignexperimental studygamma secretasein vivoinhibitor/antagonistknockout genemouse modelnotch proteinnovelorofacialoverexpressionpromotertranscription factortranscriptometranscriptome sequencing

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PROJECT SUMMARY This R21 proposal is designed to use cell and mouse models to understand the role of NOTCH-PAX9 signaling pathway in alcohol-induced esophageal injury. We hypothesize that ethanol suppresses esophageal squamous cell differentiation through inhibition of the NOTCH-PAX9 signaling. We plan to test our hypothesis with two specific aims: (1) To determine whether ethanol suppresses esophageal squamous epithelial cell differentiation through inhibition of the NOTCH-PAX9 signaling. (2) To investigate whether NOTCH activation counteracts alcohol-induced esophageal injury. These studies are aimed to elucidate the role of NOTCH-PAX9 signaling in alcohol-induced esophageal injury. If proved true, it will lay down a solid mechanistic foundation to further study NOTCH activation as a novel mechanism-based preventive measure against alcohol-induced esophageal injury.
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会议论文
NRF2-ACSS2 Axis in Alcohol-induced Metabolic Reprogramming and Esophageal Pathology
NRF2-ACSS2 Axis in Alcohol-induced Metabolic Reprogramming and Esophageal Pathology
Mechanisms and Targeted Therapy of NRF2-high Esophageal Squamous Cell Carcinoma
  • 批准号：
    10407469
  • 项目类别：
  • 资助金额：
    $16.92万
  • 财政年份：
    2020
  • 负责人：
    XIAOXIN Luke CHEN
  • 依托单位：
    NORTH CAROLINA CENTRAL UNIVERSITY
Mechanisms and Targeted Therapy of NRF2-high Esophageal Squamous Cell Carcinoma
  • 批准号：
    10530998
  • 项目类别：
  • 资助金额：
    $8.34万
  • 财政年份：
    2020
  • 负责人：
    XIAOXIN Luke CHEN
  • 依托单位：
    NORTH CAROLINA CENTRAL UNIVERSITY
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