Admin Core

管理核心

• 批准号: 10673204
• 负责人: PETER D. ADAMS
• 金额: $ 35.16万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673204
• 关键词: Acceleration; Adherence; Aging; Atlases; Benchmarking; Biological; Biological Assay; Bone Marrow; Brain; Breast; Cell Aging; Cell Separation; Cells; Cellular Assay; Cellular biology; Clinic; Collaborations; Colon; Communication; Data Analyses; Data Collection; Data Coordinating Center; Decision Making; Development; Ensure; Epigenetic Process; Experimental Designs; Funding; Goals; Group Meetings; Human; Individual; Infrastructure; Institution; Leadership; Liver; Longevity; Malignant Neoplasms; Maps; Monitor; Mus; Names; Performance; Persons; Policies; Procedures; Productivity; Protocols documentation; Recording of previous events; Regulation; Reporting; Research; Research Activity; Research Personnel; Resolution; Resource Allocation; Resources; Role; Structure; Tissue Banks; Travel; United States National Institutes of Health; Validation; data exchange; data sharing; epigenome; epigenomics; equipment acquisition; experience; experimental study; flexibility; human tissue; meetings; member; multimodality; nano-string; operation; organizational structure; programs; senescence; tissue mapping; tissue preparation; tool; transcriptomics

PROJECT SUMMARY The central goal of this murine Tissue Mapping Center (TMC) is to produce single cell resolved, multi-modal, and multiscale spatial maps of cellular senescence in murine brain, breast, colon, bone marrow and liver throughout lifespan. The Administrative Core will be responsible for providing the administrative infrastructure necessary for the operation of the Tissue Mapping Center to achieve this overall goal. The Administrative Core will coordinate, evaluate, and provide operational oversight to all components of the research program through actions such as: monitoring overall TMC progress, maintaining scientific rigor, making decisions on milestones and deliverables, allocation of resources and research core effort, equipment acquisition and management, ensuring that team members have requisite support and infrastructure maintained by their host institutions, producing/generating staffing plans, and other policies. In particular, the Core will establish a leadership plan and organizational structure centered around Administration Core Leaders, a Scientific Leadership Team, and a Program Management Team. This structure will facilitate an open, adaptable, and collaborative cycle of discovery and experimental design in support of reaching TMC milestones, as well as facilitate bi-directional interactions with the greater SenNet consortia. The Administrative Core will, through its program management team, coordinate research activities across research cores, including tissue collection, tissue preparation, cell isolation, single-cell assays, spatial assays, data analysis, experimental validation, and interpretation of results by leveraging project management tools and approaches as well as active interaction through regular team meetings, leadership committee meetings, and an annual retreat. The Program Management Team will assess milestone progress on a regular basis, providing reports to the Core Leaders and Scientific Leadership Team. Lastly, the Administrative Core will provide support for the open communication and collaboration with the larger SenNet, including SenNet leadership, NIH, Consortium Organization and Data Coordination Center (CODCC), other SenNet research groups, etc. - as well as provide the underlying administrative infrastructure to ensure the free exchange of data, resources, tools, and ideas. Throughout these activities, the core will ensure adherence to network-wide policies and procedures.

项目总结 这个小鼠组织映射中心(TMC)的中心目标是产生单细胞分辨的、多模式的、 和小鼠脑、乳腺、结肠、骨髓和肝脏细胞衰老的多尺度空间图谱 在一生中。行政核心将负责提供行政基础设施 为实现这一总体目标，组织测绘中心的运作是必要的。行政核心 将通过以下方式对研究计划的所有组成部分进行协调、评估和提供操作监督 行动，如：监测总体TMC进展，保持科学严谨性，就里程碑做出决定 和交付成果、资源分配和研究核心工作、设备采购和管理、 确保小组成员得到所在机构维护的必要支持和基础设施， 制定/生成人员配备计划和其他政策。特别是，核心将制定一项领导计划 和以行政核心领导为中心的组织结构，科学的领导团队和 项目管理团队。这种结构将促进开放、可适应和协作的循环 支持达到TMC里程碑的发现和实验设计，以及促进双向 与更大的Sennet财团的互动。行政核心将通过其计划管理 团队，协调跨研究核心的研究活动，包括组织收集、组织准备、细胞 分离、单细胞分析、空间分析、数据分析、实验验证和结果解释 通过利用项目管理工具和方法以及通过常规团队进行积极互动 会议、领导委员会会议和年度务虚会。项目管理团队将评估 定期取得里程碑式的进展，向核心领导和科学领导团队提供报告。 最后，行政核心将为与更大的 Sennet，包括Sennet Leaders、NIH、财团组织和数据协调中心(CODCC)、 其他Sennet研究小组等，以及提供基本的管理基础设施，以确保 自由交换数据、资源、工具和想法。在这些活动中，核心将确保遵守 到网络范围的政策和程序。