The single and same cell 3D atlas of epigenome and transcriptome of the lower urinary tract
下尿路表观基因组和转录组的单细胞同细胞3D图谱
基本信息
- 批准号:10673719
- 负责人:
- 金额:$ 46.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-30 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAnatomyAreaAtlasesBladderCase StudyCell NucleusCellsCloaca ChamberCollectionCommunitiesComplexCongenital AbnormalityDataData SetDevelopmentDevelopmental ProcessDigital LibrariesDiseaseDorsalEmbryoGene Expression ProfileGenerationsGenesGenitalGenitaliaGenitourinary systemGlassGoalsGraphHindgutHistologyHumanImageJointsLifeLocationLower urinary tractMapsMesenchymeMolecularMolecular ProfilingMultiomic DataMusOrganPlayReportingResearchResolutionResourcesRoleSeriesSignaling MoleculeSliceSlideSpottingsStructureStructure of umbilical arteryTechnologyTissue-Specific Gene ExpressionTissuesUreterUrethraUrinary tractVascular SystemVisualizationbladder trigonecell typedensitydesigndigitalepigenomeepigenomicsimprovedinnovationinnovative technologiesmolecular markermultiple omicsnovelresponsetranscription factortranscriptometranscriptomicsurogenital tractvirtualvirtual human
项目摘要
In response to RFA-DK-20-013 “GenitoUrinary Development Molecular Anatomy Project (GUDMAP) - Atlas
Projects”, this proposal aims “to generate data to visualize the developing urinary tract, to identify new functional
and anatomical domains, and cell types”. The embryonic hindgut or cloaca progresses from a single hollow
organ to two separate entities – the urinary tract and anorectal tract. The urinary tract further differentiates into
the bladder rostrally and the genital urethra caudally. Guided by tissue-specific gene expression patterns, we
show that several selected transcription factors and signaling molecules are critical for urinary tract development
and, are responsible for some of the most complex human birth defects. However, these low-throughput and
isolated case studies offer limited information; and it is difficult integrate these findings to discern gene-gene and
gene-cell relationships in development and in disease. Resources including spatial annotation of all genes in all
cells are needed. Using innovative technologies including single cell Multi-omics and Spatial Transcriptome, this
application aims to 1) create a series of digital libraries from all cells of mouse lower urinary tract, in which every
cell is annotated based on its' own transcriptomic and epigenomic profiles; 2) generate ultrahigh-density tissue-
specific spatial transcriptomic map of the lower urinary tract; and 3) display spatial transcriptome at near single
cell resolution onto the 3D digitalized mouse and human embryos. These resources will serve the research
community to establish a comprehensive understanding of urinary tract development, including but not limited to
cloaca septation and urinary tract differentiation.
响应RFA-DK-20-013“泌尿生殖发育分子解剖项目(GUDMAP) -图谱”
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Xue Sean Li其他文献
Xue Sean Li的其他文献
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{{ truncateString('Xue Sean Li', 18)}}的其他基金
The Kdm6a-dependent Sex Epigenome in Bladder Tumor Suppression
Kdm6a 依赖性性别表观基因组在膀胱肿瘤抑制中的作用
- 批准号:
10629080 - 财政年份:2023
- 资助金额:
$ 46.05万 - 项目类别:
Sex, Chromosomes, and Immunity in Bladder Cancer
膀胱癌中的性别、染色体和免疫
- 批准号:
10629077 - 财政年份:2023
- 资助金额:
$ 46.05万 - 项目类别:
The single and same cell 3D atlas of epigenome and transcriptome of the lower urinary tract
下尿路表观基因组和转录组的单细胞同细胞3D图谱
- 批准号:
10494214 - 财政年份:2021
- 资助金额:
$ 46.05万 - 项目类别:
The Impact of Gut Microbiota on the Sex Difference in Bladder Cancer
肠道菌群对膀胱癌性别差异的影响
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10323683 - 财政年份:2021
- 资助金额:
$ 46.05万 - 项目类别:
Molecular Basis of Sexually Dimorphic Development of the Genital Tubercle
生殖结节性别二态性发育的分子基础
- 批准号:
10362116 - 财政年份:2021
- 资助金额:
$ 46.05万 - 项目类别:
The single and same cell 3D atlas of epigenome and transcriptome of the lower urinary tract
下尿路表观基因组和转录组的单细胞同细胞3D图谱
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10356656 - 财政年份:2021
- 资助金额:
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The Six-Family Genes in Cardiovascular Development And Disease
心血管发育和疾病的六家族基因
- 批准号:
10360298 - 财政年份:2017
- 资助金额:
$ 46.05万 - 项目类别:
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