Sleep Disturbances and Circadian Misalignment as Potential Markers of Early Childhood Depression

睡眠障碍和昼夜节律失调是儿童早期抑郁症的潜在标志

• 批准号: 10673175
• 负责人: Caroline Paige Hoyniak
• 金额: $ 17.95万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673175
• 关键词: 3 year old; Adult; Age; Area; Biological Markers; Birth; Caregivers; Characteristics; Child; Chronic; Circadian Rhythms; Circadian desynchrony; Clinical; Collection; Data; Data Analyses; Data Collection; Development; Diagnosis; Disease; Early Diagnosis; Early Intervention; Environment; Funding; Goals; Home; Individual; Infant; Knowledge; Light; Longevity; Measurable; Measures; Mental Depression; Mental Health; Mentors; Methodology; Middle Insomnia; Modification; Mothers; Napping; National Institute of Mental Health; Parents; Phenotype; Polysomnography; Positioning Attribute; Psychopathology; Public Health; Relapse; Reporting; Research; Research Activity; Risk; Role; Sampling; Schedule; Science; Scientist; Sleep; Sleep Architecture; Sleep disturbances; Slow-Wave Sleep; Statistical Data Interpretation; Symptoms; System; Techniques; Testing; Toddler; Training; Training Activity; Youth; actigraphy; associated symptom; biomarker identification; career; child depression; circadian; cohort; density; depressive symptoms; diaries; early childhood; early life adversity; falls; functional disability; high risk; improved; infancy; innovation; maternal depression; multidisciplinary; novel; poor sleep; prenatal; prospective; rapid eye movement; sleep abnormalities; sleep onset; virtual

PROJECT SUMMARY Evidence in adults and youth suggests that sleep disturbances precede and predict the onset of depression and may serve as an important marker of depression. Various types of sleep disturbances, including disruptions of sleep continuity and abnormal sleep architecture, have been identified as markers of depression in adults, but have been virtually unexplored as markers of early childhood depression. Early childhood depression symptoms have become widely recognized as a significant public health concern as they are associated with functional impairments and heightened risk for depression across the lifespan. However, these symptoms often go unreported and underdiagnosed because they are difficult for caregivers and clinicians to identify. Research is needed to identify markers of early childhood depression as early as age 3 years or before, to improve our capacity for the earliest possible identification of young children struggling with, and at risk for, depression. This K23 proposal will examine sleep disturbances as a plausible marker of early childhood depressive symptoms in a prospectively examined sample of young children, oversampled for familial risk for depression. This proposal leverages an exceptional opportunity to add measures to a NIMH-funded study following a large, high-risk cohort of mother-infant dyads annually from birth through age 3. This K23 proposal will add comprehensive measures of sleep (i.e., sleep diaries, actigraphy, and polysomnography) at age 3 years to examine a) which specific features of objectively measured sleep (during both day and night) at age 3 best correlate with early childhood depression symptoms, b) whether misalignments in circadian rhythm – “chronodisruptions” – are associated with early childhood depression symptoms, and c) whether sleep disturbances in infancy and toddlerhood precede the onset of depression symptoms at age 3. This project has the potential to greatly inform our understanding of both the sequalae of sleep disturbances in early childhood, as well as identify a plausible marker of early childhood depression. Completion of the proposed project will provide the applicant with needed training and expertise in 1) the collection and analysis of PSG data in early childhood, 2) the developmental psychopathology of early childhood depression, 3) the quantification of chronodisruption in early childhood, and 4) advanced statistical analysis techniques. A rich training environment and a multidisciplinary team of mentors in each of these areas is detailed. The described research and training activities will enable the candidate to become an independent scientist investigating the role of sleep disturbances in the development of psychopathology across early childhood.

项目摘要 成人和青年的证据表明，睡眠障碍先于抑郁症和抑郁症的发作 可以作为抑郁症的重要标志。各种类型的睡眠障碍，包括 睡眠连续性和异常睡眠结构已被确定为成人抑郁症的标志，但 作为幼儿抑郁症的标志，几乎是出乎意料的。幼儿抑郁症状 由于与功能相关，已被广泛认为是一个重大的公共卫生问题 整个生命周期的障碍和抑郁症的风险增加。但是，这些症状通常会消失 未报告和诊断不足，因为他们很难看出护理人员和临床医生识别。研究是 需要在3岁或以前识别幼儿抑郁症的标记，以改善我们的 最早可能识别幼儿遇到抑郁症风险的能力。 K23提案将检查睡眠障碍是幼儿抑郁症状的合理标志 前瞻性检查的幼儿样本，因家庭抑郁症风险而被过采样。这个建议 在大型高风险队列之后，利用了一个非凡的机会，可以在NIMH资助的研究中添加测量 每年从出生到3岁的母亲二元组的二元组。该K23提案将增加全面的测量 3岁时的睡眠（即睡眠日记，行为摄影和多摄影术）检查a） 现年3岁的客观测量的睡眠（日间和黑夜）的特征与幼儿相关 抑郁症状，b）昼夜节律的未对准是否与“计时”与 儿童早期抑郁症状，c）婴儿期和幼儿的睡眠障碍是否先于 3岁时抑郁症状的发作。该项目有可能大大了解我们对 睡眠灾难的序列既在童年时期都 儿童抑郁症。拟议项目的完成将为申请人提供所需的培训和 1）幼儿期PSG数据的收集和分析，2）发展心理病理学 幼儿抑郁症，3）儿童早期的计时数量，4） 统计分析技术。丰富的培训环境和一个多学科的导师团队 这些区域是详细的。所描述的研究和培训活动将使候选人能够成为 独立科学家调查睡眠障碍在整个心理病理学发展中的作用 幼儿。