A Novel Deprescribing Intervention for Heart Failure with Preserved Ejection Fraction (HFpEF): A Prototype for Older Adults with Multimorbidity and Polypharmacy

射血分数保留 (HFpEF) 心力衰竭的新型处方干预措施：针对患有多种疾病和多药治疗的老年人的原型

• 批准号: 10673696
• 负责人: PARAG GOYAL
• 金额: $ 22.27万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673696
• 关键词: Address; Adrenergic beta-Antagonists; Adverse event; Affect; Aging; American; Area; Attention; Belief; Benefits and Risks; Biological; Biometry; Cardiac Output; Cardiology; Caring; Clinical Trials; Communication; Complex; Crossover Design; Data; Decision Making; Development; Drug Prescriptions; EFRAC; Effectiveness; Elderly; Ensure; Environment; Event; Experimental Designs; Foundations; Funding; Future; Geriatrics; Goals; Grant; Health; Health Priorities; Heart; Heart failure; Impairment; Individual; Intervention; Knowledge; Knowledge acquisition; Lead; Left; Life Expectancy; Manuscripts; Medication Management; Medicine; Mentors; Mentorship; Office Visits; Outcome; Participant; Patient Outcomes Assessments; Patients; Personal Satisfaction; Pharmaceutical Preparations; Polypharmacy; Population; Population Study; Positioning Attribute; Precision therapeutics; Principal Investigator; Process; Protocols documentation; Randomized, Controlled Trials; Research Personnel; Research Project Grants; Role; Signal Transduction; Syndrome; Testing; Time; Training; Uncertainty; United States; Variant; Ventricular; aging population; career; career development; clinical practice; college; drug withdrawal; effectiveness-implementation RCT; effectiveness/implementation hybrid; effectiveness/implementation trial; experience; hospitalization rates; implementation science; improved; improved outcome; individual patient; innovation; iterative design; mortality; multiple chronic conditions; novel; patient oriented; preference; preservation; prevent; programs; prototype; shared decision making; skills; success; supportive environment; theories; working group

PROJECT SUMMARY Candidate: My career goal is to improve the wellbeing of older adults with multiple chronic conditions and polypharmacy by developing and rigorously testing rational strategies to improve medication prescribing practices; and to become an independent clinician investigator and national leader in Geriatric Cardiology. This area is particularly relevant for me as a heart failure cardiologist, as I care for older adults who almost universally have multiple chronic conditions and polypharmacy. My track record as an emerging leader in this area is evidenced by multiple lead- and senior-author manuscripts, 4 grants as the Principal Investigator including a GEMSSTAR, my position as the Founding Director of the Weill Cornell Heart Failure with Preserved Ejection (HFpEF) Program for the Aging, and my role as the Chair of the American College of Cardiology Geriatric Cardiology Section Early Career Professionals Working Group. Mentors and Environment: This project will be conducted under the mentorship of 4 well-funded investigators who will contribute their complementary expertise in Geriatrics (Mark Lachs), Geriatric Cardiology (Mathew Maurer), Implementation Science (Monika Safford), and N-of-1 trials (Ian Kronish). Advisors in deprescribing, shared decision making, and biostatistics will provide additional content expertise to ensure the success of the proposed project and catalyze my career development. This project will take place within the supportive environment of Weill Cornell Medicine, which has demonstrated a deep commitment to my development as a clinician-investigator for the past several years. Mentored Research Project: Despite its role as an integral part of patient-centric and goal-concordant prescribing practice, deprescribing is seldom incorporated into clinical practice due to several barriers. To improve patient-centered medication management, there is a need to develop processes that can overcome these barriers. The objective of this proposal is to determine whether N- of-1 trials—as a pragmatic patient-centered approach to medication optimization that can overcome key barriers of deprescribing— can lead to increased patient confidence regarding the decision to continue or discontinue a medication. To achieve this, I will: 1) determine key features of a feasible and pragmatic protocol for deprescribing N-of-1 trials using a stakeholder-engaged iterative design approach; and 2) determine the preliminary effectiveness of an adapted N-of-1 protocol on patient decision confidence and deprescribing, and 3) determine the facilitators and barriers of implementing an adapted N-of-1 protocol into real-world clinical practice by conducting a type-1 hybrid effectiveness-implementation trial. I will achieve these aims by using ß- blocker in heart failure with preserved ejection fraction (HFpEF) as a prototype for older adults with multimorbidity and polypharmacy. This proposal will inform a future multicenter randomized controlled trial focused on improving patient-reported outcomes, and provide a formative opportunity for me to obtain the knowledge and skills necessary to become a leading researcher on patient-centered medication management.

项目摘要 候选人：我的职业目标是改善患有多种慢性疾病的老年人的健康状况， 通过开发和严格测试合理的策略来改善药物处方， 实践;并成为一个独立的临床研究人员和老年心脏病的国家领导人。这 作为一名心力衰竭心脏病专家，这一领域与我特别相关，因为我照顾的老年人几乎 普遍有多种慢性疾病和多种药物。我作为这方面的新兴领导者的记录 多个主要作者和资深作者的手稿，作为主要研究者的4笔赠款， 包括一个GEMSSTAR，我作为威尔康奈尔心脏衰竭的创始主任的职位， 保留射血（HFpEF）计划的老龄化，以及我作为主席的美国大学的作用， 心脏病学老年心脏病学科早期职业专业人员工作组。导师与环境： 该项目将在4名资金充足的调查人员的指导下进行，他们将贡献他们的 老年医学（Mark Lachs），老年心脏病学（Mathew Maurer）， 实施科学（Monika Safford）和N-of-1试验（Ian Kronish）。取消处方方面的顾问，共享 决策和生物统计学将提供额外的内容专业知识，以确保成功的 提出项目并促进我的职业发展。该项目将在支持性的 威尔康奈尔医学的环境，这表明了我作为一个发展的深刻承诺， 在过去的几年里，临床研究员。指导研究项目：尽管它的作用是一个不可分割的一部分 以病人为中心和目标一致的处方实践，取消处方很少被纳入临床 实践中遇到了一些障碍。为了改善以患者为中心的药物管理，需要 开发能够克服这些障碍的流程。本提案的目的是确定N- 作为一种务实的以患者为中心的药物优化方法， 取消处方的障碍-可能导致患者对继续或 停止服药。为了实现这一点，我将：1）确定一个可行的和务实的协议的关键特征 使用利益相关者参与的迭代设计方法取消N-of-1试验;以及2）确定 经调整的N-of-1方案对患者决策信心和取消处方的初步有效性，以及 3)确定在现实世界的临床中实施适应性N-of-1方案的促进因素和障碍 通过进行类型1混合有效性-实施试验来实践。我将通过使用这些工具来实现这些目标- 左室射血分数正常的心力衰竭阻滞剂（HFpEF）作为老年人的原型， 多药治疗和多药治疗。该建议将为未来的多中心随机对照试验提供信息 专注于改善患者报告的结果，并为我提供一个形成的机会，以获得 成为以患者为中心的药物管理的领先研究人员所需的知识和技能。

项目成果

Clinical Characteristics and Outcomes of Adults With a History of Heart Failure Hospitalized for COVID-19.

• DOI: 10.1161/circheartfailure.121.008354
• 发表时间: 2021-09
• 期刊: Circulation. Heart failure
• 作者: Goyal P;Reshetnyak E;Khan S;Musse M;Navi BB;Kim J;Allen LA;Banerjee S;Elkind MSV;Shah SJ;Yancy C;Michos ED;Devereux RB;Okin PM;Weinsaft JW;Safford MM
• 通讯作者: Safford MM

Association of Perceived Stress With Incident Heart Failure.

• DOI: 10.1016/j.cardfail.2022.04.013
• 发表时间: 2022-09
• 期刊: Journal of cardiac failure
• 影响因子: 6

Prescribing patterns of fall risk-increasing drugs in older adults hospitalized for heart failure.

• DOI: 10.1186/s12872-023-03401-w
• 发表时间: 2023-07-26
• 期刊: BMC cardiovascular disorders
• 影响因子: 2.1

Stable Coronary Artery Disease in the Age of Geriatric Cardiology.

老年心脏病学时代的稳定冠状动脉疾病。

• DOI: 10.1016/j.jacc.2023.03.378
• 发表时间: 2023
• 期刊: Journal of the American College of Cardiology
• 影响因子: 24
• 作者: Goyal,Parag;Nanna,MichaelG
• 通讯作者: Nanna,MichaelG

Prevalence of Potentially Inappropriate Medication Prescribing in US Nursing Homes, 2013-2017.

2013-2017 年美国疗养院中潜在不适当药物处方的发生率。

• DOI: 10.1007/s11606-022-07825-6
• 发表时间: 2023
• 期刊: Journal of general internal medicine
• 影响因子: 5.7
• 作者: Riester,MelissaR;Goyal,Parag;Steinman,MichaelA;Zhang,Yuan;Rodriguez,MarielaF;Paul,DakotaRome;Zullo,AndrewR
• 通讯作者: Zullo,AndrewR