Training in Malaria Epidemiology, Translational Research, and Implementation Science to Strengthen Malaria Policy and Control in Uganda

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Project summary This is a renewal application to support training in malaria epidemiology, translational research, and implementation science to strengthen malaria policy and control in Uganda. Our program has been highly successful, however, the need for training in malaria research remains great. The high burden of malaria in Uganda persists, and progress in control has stalled since 2015, with increases in incidence observed the last few years. Moreover, new challenges have arisen, including the spread of insecticide resistance, the emergence of artemisinin resistance and the COVID-19 pandemic. In contrast to the magnitude of the malaria burden in Uganda, the number of malaria researchers remains limited. These observations highlight the need for continued research that informs optimal malaria interventions, and thus a necessity for the training of Ugandans to lead this research. We propose to continue our training program, with some adjustments informed by a comprehensive needs assessment and the new challenges identified. Our long-term goal is to strengthen capacity to conduct independent and sustainable malaria research at Makerere University to address challenges of malaria control in Uganda. The objectives of this application are: 1) to expand the current program to include translational research, genomics and bioinformatics to address the complex challenges of malaria control; 2) to strengthen institutional capacity of Makerere U in malaria research by providing Master’s and PhD mentored research training for junior faculty and graduate students; 3) to substantially increase scientific leadership and expertise needed for independent malaria research in Uganda through postdoctoral training; and 4) to create sustained growth of malaria research at Makerere U by strengthening the Malaria Center. We have assembled a strong team of program faculty from Uganda, the US and Europe already collaborating on several research projects in Uganda, and with extensive experience in research and higher-level training, to ensure high-quality supervision and mentoring of trainees. Degree and non-degree training will occur in Uganda and collaborating institutions. In the next five years, we will train candidates as follows: 1) five in 2-year post-doctoral programs; 2) five in 4-year PhD programs; 3) eight in 2- year master’s degree programs; and 4) four in a 1–2-year Implementation Science fellowship. Trainees will be required to take didactic courses, conduct mentored research projects, and acquire professional development skills through participation in Malaria Center activities. The intended outcomes are: 1) establishment of a critical mass of Ugandan scientists trained in malaria research; 2) increased malaria research outputs at Makerere U including scientific publications and new research grants; and 3) increased dissemination of generated evidence to inform the design and implementation of programs and policies to control malaria in Uganda. Improved expertise in malaria research will be critical to assist the Ministry of Health in establishing effective policies for better control and eventual elimination of malaria in Uganda.