Training in Malaria Epidemiology, Translational Research, and Implementation Science to Strengthen Malaria Policy and Control in Uganda

疟疾流行病学、转化研究和实施科学培训，以加强乌干达的疟疾政策和控制

• 批准号: 10673216
• 负责人: MATTHEW G DORSEY
• 金额: $ 29.72万
• 依托单位: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673216
• 关键词: Address; Artemisinins; Bioinformatics; COVID-19 pandemic; Collaborations; Complex; Degree program; Doctor of Philosophy; Educational Status; Ensure; Epidemiology; Europe; Faculty; Fellowship; Genomics; Goals; Growth; Health; Incidence; Insecticide Resistance; Institution; Intervention; Lead; Leadership; Malaria; Master of Science; Mentors; Needs Assessment; Outcome; Output; Policies; Postdoctoral Fellow; Publications; Research; Research Personnel; Research Project Grants; Research Training; Resistance; Scientist; Supervision; Training; Training Programs; Training Support; Translational Research; Uganda; Universities; design; experience; graduate student; implementation science; improved; institutional capacity; post-doctoral training; programs; skill acquisition

Project summary This is a renewal application to support training in malaria epidemiology, translational research, and implementation science to strengthen malaria policy and control in Uganda. Our program has been highly successful, however, the need for training in malaria research remains great. The high burden of malaria in Uganda persists, and progress in control has stalled since 2015, with increases in incidence observed the last few years. Moreover, new challenges have arisen, including the spread of insecticide resistance, the emergence of artemisinin resistance and the COVID-19 pandemic. In contrast to the magnitude of the malaria burden in Uganda, the number of malaria researchers remains limited. These observations highlight the need for continued research that informs optimal malaria interventions, and thus a necessity for the training of Ugandans to lead this research. We propose to continue our training program, with some adjustments informed by a comprehensive needs assessment and the new challenges identified. Our long-term goal is to strengthen capacity to conduct independent and sustainable malaria research at Makerere University to address challenges of malaria control in Uganda. The objectives of this application are: 1) to expand the current program to include translational research, genomics and bioinformatics to address the complex challenges of malaria control; 2) to strengthen institutional capacity of Makerere U in malaria research by providing Master’s and PhD mentored research training for junior faculty and graduate students; 3) to substantially increase scientific leadership and expertise needed for independent malaria research in Uganda through postdoctoral training; and 4) to create sustained growth of malaria research at Makerere U by strengthening the Malaria Center. We have assembled a strong team of program faculty from Uganda, the US and Europe already collaborating on several research projects in Uganda, and with extensive experience in research and higher-level training, to ensure high-quality supervision and mentoring of trainees. Degree and non-degree training will occur in Uganda and collaborating institutions. In the next five years, we will train candidates as follows: 1) five in 2-year post-doctoral programs; 2) five in 4-year PhD programs; 3) eight in 2- year master’s degree programs; and 4) four in a 1–2-year Implementation Science fellowship. Trainees will be required to take didactic courses, conduct mentored research projects, and acquire professional development skills through participation in Malaria Center activities. The intended outcomes are: 1) establishment of a critical mass of Ugandan scientists trained in malaria research; 2) increased malaria research outputs at Makerere U including scientific publications and new research grants; and 3) increased dissemination of generated evidence to inform the design and implementation of programs and policies to control malaria in Uganda. Improved expertise in malaria research will be critical to assist the Ministry of Health in establishing effective policies for better control and eventual elimination of malaria in Uganda.

项目概要 这是一个更新应用程序，用于支持疟疾流行病学、转化研究和 实施科学以加强乌干达的疟疾政策和控制。我们的计划得到了高度评​​价 然而，尽管疟疾研究取得了成功，但对培训的需求仍然很大。疟疾负担沉重 乌干达的情况持续存在，自 2015 年以来控制进展陷入停滞，观察到发病率有所增加 过去几年。此外，还出现了新的挑战，包括杀虫剂抗药性的蔓延、 青蒿素耐药性的出现和 COVID-19 大流行。与疟疾的严重程度形成鲜明对比 在乌干达，疟疾研究人员的数量仍然有限。这些观察结果凸显了需要 继续进行研究，为最佳疟疾干预措施提供信息，因此有必要培训 乌干达人领导这项研究。我们建议继续我们的培训计划，并进行一些调整 全面的需求评估和确定的新挑战提供了信息。我们的长期目标是 加强麦克雷雷大学开展独立和可持续疟疾研究的能力 解决乌干达疟疾控制方面的挑战。该应用程序的目标是： 1) 扩展 目前的计划包括转化研究、基因组学和生物信息学，以解决复杂的问题 疟疾控制的挑战； 2) 加强麦克雷雷大学在疟疾研究方面的机构能力 为初级教师和研究生提供硕士和博士指导的研究培训； 3）到 大幅提高乌干达独立疟疾研究所需的科学领导力和专业知识 通过博士后培训； 4) 促进马凯雷雷大学疟疾研究的持续增长 加强疟疾中心。我们组建了一支强大的项目教师团队，来自乌干达、 美国和欧洲已经在乌干达合作开展多个研究项目，并拥有丰富的经验 在研究和更高水平的培训方面，确保对学员的高质量监督和指导。程度 非学位培训将在乌干达和合作机构进行。未来五年，我们将培养 候选人如下： 1）2年制博士后5名； 2) 4年制博士课程5个； 3) 八合二- 年硕士学位课程； 4) 四项为期 1-2 年的实施科学奖学金。学员将 需要参加教学课程，进行指导研究项目，并获得专业知识 通过参与疟疾中心的活动来发展技能。预期结果是：1） 培养一批受过疟疾研究培训的乌干达科学家； 2）疟疾增加 麦克雷雷大学的研究成果，包括科学出版物和新的研究资助； 3）增加 传播生成的证据，为方案和政策的设计和实施提供信息， 控制乌干达的疟疾。提高疟疾研究方面的专业知识对于协助卫生部至关重要 卫生部门制定有效政策以更好地控制并最终消除乌干达的疟疾。