Alzheimer's-focused Celdara Medical High-Potential Entrepreneurial Fellowship Program (A-CHEF)

虽然大多数生物医学科学家最终都在学术界以外的职业中工作，但大多数人几乎没有接受过为这一过渡做准备的培训。在这里，我们寻求建立一个全面的培训计划，为科学家的实际职业生涯做好准备：满足国家最大的生物医学和临床需求。该计划包括核心课程，涵盖药物开发的关键方面(例如，尽职调查、临床前开发、临床未得到满足的需求、知识产权管理、监管路径、融资、竞争情报和科学交流)、体验式学习、与生物技术专业人员的定期、结构化合作、SBIR授权机制和写作培训、与多家早期生物技术公司的接触、互补性在线培训平台，以及正式的指导计划。本节目将重点关注21世纪最关键的疾病之一：阿尔茨海默病(AD)和 被命名为专注于阿尔茨海默氏症的Celdara医疗高潜力企业家联谊会(A-chef)。Celdara Medical(CM)是一家创业型生物技术公司，将学术创新转化为高潜力的疗法。A-Chef将由CM与八所大学合作运营：布朗大学、达特茅斯大学、缅因州医学中心、MDI生物实验室、UDel、UNH、URI和UVM。CM目前通过其对NIGMS资助的区域加速器中心--驱动式加速器中心的领导，与这些大学中的每一所大学进行合作。CM之前曾与达特茅斯学院合作开展了一个奖学金项目(Celdara奖学金)，作为A-Chef的试点研究。Celdara奖学金提供了成功的证据，以及一个正式、扩展和改进的基本培训结构。A-Chef年度里程碑：1)培训来自东北IDEA的5名不同的科学家每年陈述生物医学创业/药物开发；每个研究员将(每年)：a)完成A-≥教学培训b)完成对≥30 AD相关疗法的尽职调查；c)准备至少一个AD治疗推介并提交给CM和受驱动的团队；d)创建和迭代适应性个人发展计划(IDP)。2)为≥1 AD治疗制定完整的资金和开发计划(从临床前到临床)。成功完成本申请中概述的目标和里程碑将为生物医学科学家提供宝贵的身临其境的培训和职业发展，同时还将扩大AD研究队伍和推进AD治疗开发。

While the majority of biomedical scientists end up in professions outside of academia, most receive little-to-no training in preparation for this transition. Here, we seek to establish a comprehensive training program to prepare scientists for their actual careers: to meet the nation’s greatest biomedical and clinical needs. This program includes a core curriculum covering key aspects of drug development (e.g., due diligence, preclinical development, clinical unmet need, intellectual property management, regulatory path, financing, competitive intelligence, and scientific communication), experiential learning, regular, structured collaboration with biotech professionals, training in SBIR grant mechanisms and writing, engagement with multiple early-stage biotech companies, a complementary online training platform, and a formal mentoring program. This program will be focused on one of the most critical disease-challenges of the 21st century: Alzheimer’s Disease (AD) and is named the Alzheimer’s-focused Celdara Medical High-Potential Entrepreneurs’ Fellowship (A-CHEF). Celdara Medical (CM) is an entrepreneurial biotech company that builds academic innovations into high-potential therapeutics. A-CHEF will be run by CM in collaboration with eight universities: Brown, Dartmouth, Maine Medical Center, MDI Biological Laboratory, UDel, UNH, URI, and UVM. CM currently collaborates with each of these universities through its leadership of the NIGMS-funded Regional Accelerator Hub, the DRIVEN Accelerator Hub. CM has previously run a fellowship program (Celdara fellowship) in collaboration with Dartmouth College that acts as a pilot study for A-CHEF. The Celdara fellowship provides evidence of success, as well as a basic training structure to formalize, expand, and improve upon. A-CHEF Annual Milestones: 1) Train ≥ 5 diverse scientists from the Northeast IDeA states each year in biomedical entrepreneurship / drug development; each Fellow will (annually): a) Complete A-CHEF didactic training b) Complete due diligence on ≥ 30 AD-relevant therapeutics; c) Prepare at least one AD therapeutic pitch and present to the CM and DRIVEN teams; d) Create and iterate upon an adaptive individual development plan (IDP). 2) Create a complete funding and development plan (preclinical to clinical) for ≥1 AD therapeutic. Successful completion of the aims and milestones outlined in this application will provide invaluable immersive training and career development for biomedical scientists while also expanding the AD research workforce and advancing AD therapeutic development.