Breathing Research and Therapeutics (BREATHE)

呼吸研究和治疗（BREATHE）

• 批准号: 10675054
• 负责人: Gordon S. Mitchell
• 金额: $ 46.07万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-15 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10675054
• 关键词: Breathing; Research; Therapeutic

PROJECT SUMMARY/ABSTRACT We propose renewed funding of the Breathing Research and Therapeutics (BREATHE) Training Program at the University of Florida (UF). This combined predoctoral and postdoctoral training program, which began in 2017, is focused on the respiratory neuromuscular system, emphasizing discovery of new knowledge and its translation to severe clinical disorders that compromise breathing capacity, stability and airway defense. In just over 4 years, with a “ramp-up” of 2 years, we established an internationally known training program with a “unique focus, unlike any other” (quote from anonymous NIH reviewer); we are unaware of any other T32 with a similar concentration on breathing and airway defense in traumatic, ischemic, infectious or degenerative clinical disorders, despite their high cumulative prevalence and importance. Nine predoctoral and 7 postdoctoral trainees have been funded through the BREATHE training program, including those supported by institutional match funds; all graduates thus far have continued in academic, biomedical or research positions (eg. assistant professor, clinical research director, K99 awardee, postdoc fellows, grant writer). We successfully recruited demographically and scientifically diverse trainees (56% women, 31% underrepresented groups, 44% clinically qualified, 19% engineering backgrounds). In this renewal application, we seek funds to continue building and refining this unique program, with the goal of training the next generation of scientists devoted to preserving and restoring breathing and airway defense in clinical disorders that most often end life by respiratory failure. Our intent is to establish a cohort of respiratory scientists with diverse backgrounds capable of engaging in basic discovery and/or clinical/translational research, with the necessary background and skills to work independently and in interdisciplinary teams. BREATHE emphasizes training in respiratory neural and muscle plasticity, and development of new therapeutic strategies to treat patients with compromised breathing capacity, stability and/or airway defense. Our objectives are: 1) recruit a diverse cohort of high-quality basic science and clinical predoctoral (3/year) and postdoctoral (4/year) trainees with an interest in breathing research and therapeutics, and potential for independent research careers; 2) implement a carefully designed training program that provides predoctoral and postdoctoral trainees with solid foundations in respiratory biology, airway defense and translational research, and the technical, analytical and professional skills necessary for productive research careers; and 3) foster an interdisciplinary, collaborative research environment conducive to preparing scientists for successful careers in interdisciplinary research. The UF environment includes collaborative faculty mentors with diverse and complementary expertise, state-of-the-art facilities, ongoing translational research partnerships and a rich menu of career development opportunities. Our renewal application builds on proven elements, with an emphasis on being responsive to the rapidly changing landscape of respiratory research.

项目总结/摘要 我们建议重新资助呼吸研究和治疗（呼吸）培训计划， 佛罗里达大学。这个结合了博士前和博士后培训计划，始于2017年， 专注于呼吸神经肌肉系统，强调新知识的发现及其翻译 严重的临床疾病，危及呼吸能力，稳定性和气道防御。在刚刚超过4 2000年，经过两年的“爬坡”，我们建立了一个国际知名的培训计划，具有“独特的 焦点，不像任何其他”（引用匿名NIH评论家）;我们不知道任何其他T32具有类似的 在创伤性、缺血性、感染性或退行性临床中， 尽管这些疾病的累积患病率和重要性很高，9名博士前和7名博士后学员 已通过呼吸培训计划资助，包括那些由机构匹配支持 基金;迄今为止，所有毕业生都继续在学术，生物医学或研究职位（如。助理 教授，临床研究主任，K99获奖者，博士后研究员，资助作家）。我们成功招募到 在人口和科学方面多样化的受训人员（56%为妇女，31%为代表不足的群体，44%为临床 19%的工程背景）。在这次更新申请中，我们寻求资金继续建设， 完善这一独特的计划，目标是培养下一代致力于保护自然的科学家。 以及在临床疾病中恢复呼吸和气道防御， 失败我们的目的是建立一个具有不同背景的呼吸科学家队伍， 在基础发现和/或临床/转化研究，具有必要的背景和技能的工作 独立地和跨学科的团队。呼吸强调呼吸神经和肌肉的训练 可塑性，以及开发新的治疗策略来治疗呼吸能力受损的患者， 稳定性和/或气道防御。我们的目标是：1）招募高质量的基础科学和 对呼吸研究感兴趣的临床博士前（3/年）和博士后（4/年）学员， 治疗学和独立研究事业的潜力; 2）实施精心设计的培训计划 为博士前和博士后学员提供呼吸生物学，气道防御， 和翻译研究，以及生产性研究所需的技术，分析和专业技能 职业;和3）促进有利于培养科学家的跨学科，合作研究环境 在跨学科研究中取得成功。UF环境包括协作教师导师 拥有多样化和互补的专业知识，最先进的设施，持续的转化研究伙伴关系 以及丰富的职业发展机会。我们的更新应用程序基于经过验证的元素， 强调对呼吸研究的快速变化做出反应。

项目成果

APOE4, Age, and Sex Regulate Respiratory Plasticity Elicited by Acute Intermittent Hypercapnic-Hypoxia.

• DOI: 10.1093/function/zqad026
• 发表时间: 2023
• 期刊: FUNCTION
• 影响因子: 6.2
• 作者: Nair, Jayakrishnan;Welch, Joseph F.;Marciante, Alexandria B.;Hou, Tingting;Lu, Qing;Fox, Emily J.;Mitchell, Gordon S.
• 通讯作者: Mitchell, Gordon S.

Activation of orexin-2 receptors in the Kӧlliker-Fuse nucleus of anesthetized mice leads to transient slowing of respiratory rate.

• DOI: 10.3389/fphys.2022.977569
• 发表时间: 2022
• 期刊: FRONTIERS IN PHYSIOLOGY
• 影响因子: 4
• 作者: Varga, Adrienn G. G.;Whitaker-Fornek, Jessica R. R.;Maletz, Sebastian N. N.;Levitt, Erica S. S.
• 通讯作者: Levitt, Erica S. S.

Frontal White Matter Hyperintensities and Executive Functioning Performance in Older Adults.

• DOI: 10.3389/fnagi.2021.672535
• 发表时间: 2021
• 期刊: Frontiers in aging neuroscience
• 影响因子: 4.8
• 作者: Boutzoukas EM;O'Shea A;Albizu A;Evangelista ND;Hausman HK;Kraft JN;Van Etten EJ;Bharadwaj PK;Smith SG;Song H;Porges EC;Hishaw A;DeKosky ST;Wu SS;Marsiske M;Alexander GE;Cohen R;Woods AJ
• 通讯作者: Woods AJ

APOE4, Age & Sex Regulate Respiratory Plasticity Elicited By Acute Intermittent Hypercapnic-Hypoxia.

APOE4、年龄

• DOI: 10.1101/2023.01.06.522840
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Nair,Jayakrishnan;Welch,JosephF;Marciante,AlexandriaB;Hou,Tingting;Lu,Qing;Fox,EmilyJ;Mitchell,GordonS
• 通讯作者: Mitchell,GordonS

A Neuromodulatory System that Links Opioid-Induced Sedation and Respiratory Depression.

将阿片类药物引起的镇静和呼吸抑制联系起来的神经调节系统。

• 发表时间: 2022
• 期刊: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
• 作者: Varga,AdriennG;Maletz,SebastianN;Dossat,AmandaM;Reid,BrandonT;Levitt,EricaS
• 通讯作者: Levitt,EricaS