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Animal & Tissue Imaging Shared Resource

动物

基本信息

批准号：
10675630
负责人：
Lloyd C Trotman
金额：
$ 45.51万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10675630
关键词：
3-Dimensional Anatomy Animal Cancer Model Animals Cancer Biology Cancer Center Cancer Center Support Grant Cancer Center at Cold Spring Harbor Laboratory Cancer Diagnostics Cancer Model Cell Survival Color Data Analyses Development Disease Doctor of Philosophy Dose Education Educational workshop Equipment Evaluation Experimental Designs Faculty Funding Future Gamma counter Goals Head Histologic Histology Human Image Image Analysis Imaging Techniques ImmunoPET Immunofluorescence Immunologic Immunohistochemistry In Situ Hybridization Individual Ionizing radiation Lesion Measures Methods Mission Modality Molecular Mus Neoplasm Metastasis Optics PET/CT scan Pathology Physiological Positron-Emission Tomography Preparation Primary Neoplasm Printing Publications Reagent Reporter Research Research Personnel Research Project Grants Resolution Resource Sharing Resources Sampling Scanning Services Slide Stains Students Surveys Teacher Professional Development Technology Tissue Microarray Tissue imaging Training Tumor Biology Tumor Tissue Ultrasonography animal imaging anticancer research bioluminescence imaging cancer imaging cryostat drug sensitivity ex vivo imaging experience fluorescence imaging imager imaging approach imaging modality in vivo in vivo imaging innovation instrument instrumentation interest lectures member neoplastic cell non-invasive imaging novel novel diagnostics novel therapeutic intervention optical imaging pre-clinical response single photon emission computed tomography tissue preparation tissue processing tool tumor tumor heterogeneity tumor microenvironment ultrasound user-friendly

项目摘要

ANIMAL & TISSUE IMAGING SHARED RESOURCE – PROJECT SUMMARY/ABSTRACT This Shared Resource provides histology services for the characterization of murine and human tumor tissue and the evaluation of animal pathology. The samples submitted for analysis are analyzed with the latest technology and to the highest quality standards. Moreover, Cancer Center members have access to instrumentation for non-invasive ultrasound, bioluminescence, and fluorescence imaging to advance the molecular and physiological understanding of cancer biology. Furthermore, the exceptional expertise of the Shared Resource staff allows collaborative development of innovative approaches to highly specific and sensitive in vivo imaging using PET/CT and SPECT/CT instruments. These novel methods have particular application in assessing tumor response to experimental treatment, and to help develop and characterize novel diagnostic or therapeutic approaches. Overall, the goal of this Shared Resource is to provide support that leads to a deeper mechanistic understanding of cancer biology, and also to greatly advance the evaluation and characterization of cancer animal models at the CSHL Cancer Center. This Shared Resource is led by Faculty Head Lloyd Trotman, Ph.D., Director Scott Lyons, Ph.D, and Manager Qing Gao, Ph.D. In the last five-year period, this Shared Resource was used by 21 Cancer Center members (55% of members), and resulted in 40 publications or preprints.

动物和组织成像共享资源-项目摘要/摘要该共享资源为描述小鼠和人类肿瘤组织的特征提供组织学服务动物病理学评价。提交进行分析的样品是用最新的技术和最高的质量标准。此外，癌症中心成员还可以访问用于无创超声、生物发光和荧光成像的仪器，以促进对癌症生物学的分子和生理方面的了解。此外，该公司的非凡专业知识共享资源员工允许协作开发创新方法，以实现高度具体和使用PET/CT和SPECT/CT仪器进行灵敏的活体成像。这些新的方法具有特殊的在评估肿瘤对实验性治疗的反应以及帮助开发和表征新技术方面的应用诊断或治疗方法。总体而言，此共享资源的目标是提供以下支持以加深对癌症生物学的机理理解，并极大地促进评估和 CSHL癌症中心癌症动物模型的特征。此共享资源由教职员工领导劳埃德·特罗特曼博士、斯科特·莱昂斯主任博士和高青经理博士在此期间，该共享资源被21个癌症中心成员(55%的成员)使用，并导致40个出版物或预印本。