Animal & Tissue Imaging Shared Resource

动物

• 批准号: 10675630
• 负责人: Lloyd C Trotman
• 金额: $ 45.51万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10675630
• 关键词: 3-Dimensional; Anatomy; Animal Cancer Model; Animals; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Center at Cold Spring Harbor Laboratory; Cancer Diagnostics; Cancer Model; Cell Survival; Color; Data Analyses; Development; Disease; Doctor of Philosophy; Dose; Education; Educational workshop; Equipment; Evaluation; Experimental Designs; Faculty; Funding; Future; Gamma counter; Goals; Head; Histologic; Histology; Human; Image; Image Analysis; Imaging Techniques; ImmunoPET; Immunofluorescence Immunologic; Immunohistochemistry; In Situ Hybridization; Individual; Ionizing radiation; Lesion; Measures; Methods; Mission; Modality; Molecular; Mus; Neoplasm Metastasis; Optics; PET/CT scan; Pathology; Physiological; Positron-Emission Tomography; Preparation; Primary Neoplasm; Printing; Publications; Reagent; Reporter; Research; Research Personnel; Research Project Grants; Resolution; Resource Sharing; Resources; Sampling; Scanning; Services; Slide; Stains; Students; Surveys; Teacher Professional Development; Technology; Tissue Microarray; Tissue imaging; Training; Tumor Biology; Tumor Tissue; Ultrasonography; animal imaging; anticancer research; bioluminescence imaging; cancer imaging; cryostat; drug sensitivity; ex vivo imaging; experience; fluorescence imaging; imager; imaging approach; imaging modality; in vivo; in vivo imaging; innovation; instrument; instrumentation; interest; lectures; member; neoplastic cell; non-invasive imaging; novel; novel diagnostics; novel therapeutic intervention; optical imaging; pre-clinical; response; single photon emission computed tomography; tissue preparation; tissue processing; tool; tumor; tumor heterogeneity; tumor microenvironment; ultrasound; user-friendly

ANIMAL & TISSUE IMAGING SHARED RESOURCE – PROJECT SUMMARY/ABSTRACT This Shared Resource provides histology services for the characterization of murine and human tumor tissue and the evaluation of animal pathology. The samples submitted for analysis are analyzed with the latest technology and to the highest quality standards. Moreover, Cancer Center members have access to instrumentation for non-invasive ultrasound, bioluminescence, and fluorescence imaging to advance the molecular and physiological understanding of cancer biology. Furthermore, the exceptional expertise of the Shared Resource staff allows collaborative development of innovative approaches to highly specific and sensitive in vivo imaging using PET/CT and SPECT/CT instruments. These novel methods have particular application in assessing tumor response to experimental treatment, and to help develop and characterize novel diagnostic or therapeutic approaches. Overall, the goal of this Shared Resource is to provide support that leads to a deeper mechanistic understanding of cancer biology, and also to greatly advance the evaluation and characterization of cancer animal models at the CSHL Cancer Center. This Shared Resource is led by Faculty Head Lloyd Trotman, Ph.D., Director Scott Lyons, Ph.D, and Manager Qing Gao, Ph.D. In the last five-year period, this Shared Resource was used by 21 Cancer Center members (55% of members), and resulted in 40 publications or preprints.

动物和组织成像共享资源-项目总结/摘要 这个共享资源提供了组织学服务的特点，小鼠和人类肿瘤组织 和动物病理学评价。提交分析的样品采用最新的 技术和最高的质量标准。此外，癌症中心的成员可以获得 用于非侵入性超声、生物发光和荧光成像的仪器， 癌症生物学的分子和生理学理解。此外， 共享资源工作人员允许协作开发创新方法， 使用PET/CT和SPECT/CT仪器进行灵敏的体内成像。这些新方法具有特殊的 应用于评估肿瘤对实验治疗的反应，并帮助开发和表征新的 诊断或治疗方法。总体而言，此共享资源的目标是提供支持， 更深入地了解癌症生物学的机制，并大大推进评估， CSHL癌症中心的癌症动物模型的表征。该资源由教师领导 负责人劳埃德·特罗特曼博士，董事Scott里昂博士和经理高庆博士在过去的五年里， 在此期间，该共享资源被21名癌症中心成员（55%的成员）使用，并导致40 出版物或预印本。