Cancer Immunology

癌症免疫学

基本信息

  • 批准号:
    10674510
  • 负责人:
  • 金额:
    $ 2.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-08-01 至 2025-07-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT – CANCER IMMUNOLOGY (CI) PROGRAM The Cancer Immunology (CI) Program of The Tisch Cancer Institute (TCI) is comprised of 30 members who share a common goal to investigate the premise that immune-mediated dysregulation adversely impacts the TME. They represent 15 Departments and 7 Institutes. As of February 2019, CI program members were awarded $8.8 million in direct cost funding, with NCI support of $2.5 million and peer-reviewed cancer related support of $5 million. In 2018, the program published 72 papers of which 30% were intra- and 18% were inter- programmatic. The major scientific themes of the CI program are to investigate: 1. Immune dysregulation in the Tumor Microenvironment (TME); 2. Develop models to reverse immune dysfunction and restore immune balance; and 3. Validate correlates of response in cancer patients receiving immunotherapy. Cancer progression is characterized by gradual dysregulation of the immune system at multiple levels that directly contributes to unchecked tumor growth. While the role of T cell dysfunction is well acknowledged, evidence is accumulating that the innate immune system is analogously hijacked to enable tumor growth. In this regard, CI Program members are focused on identifying new mechanisms whereby the tumor microenvironment (TME) impacts the function of innate immune cells including macrophages, dendritic cells and NK cells, in addition to tumor-reactive T cells. Accordingly, the CI program has three main scientific goals. The first is to identify genomic, molecular and cellular pathways underlying immune dysfunction in the TME. CI members use preclinical model systems, CRISPR screens and human tumor lesions, to identify novel mechanisms/targets underlying immune dysregulation and prioritize targets of immunotherapy resistance/response ultimately tested in novel clinical trials. Second, CI members strive to develop scientifically based strategies that will improve and/or expand current immunotherapeutic platforms, and identify immune biomarkers of risk and response to treatment. The overarching goal is to progress discoveries that are made into innovative clinical trials to test and validate proposed correlates of resistance and response. A third goal is to develop novel clinically applicable immune targets to effectively control or eradicate cancers. CI members work in partnership and inter-programmatically to validate correlates of resistance to immunotherapy.
项目摘要/摘要-癌症免疫学(ci)计划

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Nina Bhardwaj其他文献

Nina Bhardwaj的其他文献

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{{ truncateString('Nina Bhardwaj', 18)}}的其他基金

The Tisch Cancer Institute (TCI) Paul Calabresi K12 Career Development Award for Clinical Oncology
蒂施癌症研究所 (TCI) Paul Calabresi K12 临床肿瘤学职业发展奖
  • 批准号:
    10434380
  • 财政年份:
    2022
  • 资助金额:
    $ 2.63万
  • 项目类别:
The Tisch Cancer Institute (TCI) Paul Calabresi K12 Career Development Award for Clinical Oncology
蒂施癌症研究所 (TCI) Paul Calabresi K12 临床肿瘤学职业发展奖
  • 批准号:
    10623252
  • 财政年份:
    2022
  • 资助金额:
    $ 2.63万
  • 项目类别:
Dissecting myeloid cell-mediated resistance to immune checkpoint blockade in bladder cancer
剖析膀胱癌中骨髓细胞介导的免疫检查点阻断抵抗
  • 批准号:
    10652272
  • 财政年份:
    2020
  • 资助金额:
    $ 2.63万
  • 项目类别:
Dissecting myeloid cell-mediated resistance to immune checkpoint blockade in bladder cancer
剖析膀胱癌中骨髓细胞介导的免疫检查点阻断抵抗
  • 批准号:
    10380068
  • 财政年份:
    2020
  • 资助金额:
    $ 2.63万
  • 项目类别:
Effect of SARS-CoV-2 on clinical course and NK cells in patients receiving immunotherapy
SARS-CoV-2 对接受免疫治疗的患者临床病程和 NK 细胞的影响
  • 批准号:
    10203557
  • 财政年份:
    2020
  • 资助金额:
    $ 2.63万
  • 项目类别:
NK cell exhaustion in metastatic melanoma
转移性黑色素瘤中 NK 细胞耗竭
  • 批准号:
    9177359
  • 财政年份:
    2016
  • 资助金额:
    $ 2.63万
  • 项目类别:
Cancer Immunology
癌症免疫学
  • 批准号:
    10454170
  • 财政年份:
    2015
  • 资助金额:
    $ 2.63万
  • 项目类别:
Cancer Immunology (CI) (Project-001)
癌症免疫学 (CI)(项目-001)
  • 批准号:
    8932191
  • 财政年份:
    2015
  • 资助金额:
    $ 2.63万
  • 项目类别:
Cancer Immunology
癌症免疫学
  • 批准号:
    10022663
  • 财政年份:
    2015
  • 资助金额:
    $ 2.63万
  • 项目类别:
Matrix metalloproteinase-2 modulates inflammation via TLR2
基质金属蛋白酶-2 通过 TLR2 调节炎症
  • 批准号:
    8777819
  • 财政年份:
    2014
  • 资助金额:
    $ 2.63万
  • 项目类别:

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