Cancer Immunology
癌症免疫学
基本信息
- 批准号:10674510
- 负责人:
- 金额:$ 2.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-08-01 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:Animal ModelAwardBiological ModelsCRISPR screenCancer Center Support GrantCancer PatientCellsCellular Indexing of Transcriptomes and Epitopes by SequencingClinical TrialsClustered Regularly Interspaced Short Palindromic RepeatsDendritic CellsDevelopmentDirect CostsDoctor of PhilosophyElementsEquilibriumFunctional disorderFundingGenomicsGoalsHumanImmuneImmune System DiseasesImmune TargetingImmune checkpoint inhibitorImmune responseImmune systemImmunologic MarkersImmunologyImmunotherapeutic agentImmunotherapyInnate Immune SystemIntrinsic factorLeadershipLesionMacrophageMalignant NeoplasmsMediatingModelingMolecularMyeloid-derived suppressor cellsNatural Killer CellsPaperPathway interactionsPatientsPeer ReviewPopulationPre-Clinical ModelPublishingRefractoryResearch PersonnelResistanceRiskRoleSamplingStromal CellsT cell therapyT-LymphocyteTechnologyTestingTranslatingWorkanti-CTLA4anti-PD-1anti-PD-L1cancer carecancer cellcancer therapychimeric antigen receptor T cellsclinical applicationclinical investigationdesignhuman diseaseimprovedin silicoinnate immune functioninnovationmedical schoolsmembernovelpre-clinicalprogramsrecruitresponseresponse biomarkersingle cell sequencingtreatment responsetumortumor growthtumor immunologytumor microenvironmenttumor progression
项目摘要
PROJECT SUMMARY/ABSTRACT – CANCER IMMUNOLOGY (CI) PROGRAM
The Cancer Immunology (CI) Program of The Tisch Cancer Institute (TCI) is comprised of 30 members who
share a common goal to investigate the premise that immune-mediated dysregulation adversely impacts the
TME. They represent 15 Departments and 7 Institutes. As of February 2019, CI program members were
awarded $8.8 million in direct cost funding, with NCI support of $2.5 million and peer-reviewed cancer related
support of $5 million. In 2018, the program published 72 papers of which 30% were intra- and 18% were inter-
programmatic.
The major scientific themes of the CI program are to investigate: 1. Immune dysregulation in the Tumor
Microenvironment (TME); 2. Develop models to reverse immune dysfunction and restore immune balance; and
3. Validate correlates of response in cancer patients receiving immunotherapy. Cancer progression is
characterized by gradual dysregulation of the immune system at multiple levels that directly contributes to
unchecked tumor growth. While the role of T cell dysfunction is well acknowledged, evidence is accumulating
that the innate immune system is analogously hijacked to enable tumor growth. In this regard, CI Program
members are focused on identifying new mechanisms whereby the tumor microenvironment (TME) impacts the
function of innate immune cells including macrophages, dendritic cells and NK cells, in addition to tumor-reactive
T cells.
Accordingly, the CI program has three main scientific goals. The first is to identify genomic, molecular and
cellular pathways underlying immune dysfunction in the TME. CI members use preclinical model systems,
CRISPR screens and human tumor lesions, to identify novel mechanisms/targets underlying immune
dysregulation and prioritize targets of immunotherapy resistance/response ultimately tested in novel clinical
trials. Second, CI members strive to develop scientifically based strategies that will improve and/or expand
current immunotherapeutic platforms, and identify immune biomarkers of risk and response to treatment. The
overarching goal is to progress discoveries that are made into innovative clinical trials to test and validate
proposed correlates of resistance and response. A third goal is to develop novel clinically applicable immune
targets to effectively control or eradicate cancers. CI members work in partnership and inter-programmatically
to validate correlates of resistance to immunotherapy.
项目总结/摘要-癌症免疫学(CI)研究
Tisch癌症研究所(TCI)的癌症免疫学(CI)项目由30名成员组成,
有一个共同的目标,即研究免疫介导的失调对免疫系统产生不利影响的前提。
TME。他们代表15个部门和7个研究所。截至2019年2月,CI计划成员为
获得了880万美元的直接成本资金,NCI支持了250万美元,
500万元的支持。2018年,该计划发表了72篇论文,其中30%是内部论文,18%是内部论文。
纲领性的。
CI计划的主要科学主题是调查:1。肿瘤中的免疫失调
微环境(TME); 2.开发模型以逆转免疫功能障碍并恢复免疫平衡;以及
3.接受免疫治疗的癌症患者中的反应相关性。癌症进展
其特征是免疫系统在多个水平上逐渐失调,
不受控制的肿瘤生长虽然T细胞功能障碍的作用是众所周知的,
先天免疫系统被类似地劫持以使肿瘤生长。在这方面,CI计划
成员们专注于确定肿瘤微环境(TME)影响肿瘤微环境的新机制。
先天免疫细胞包括巨噬细胞、树突状细胞和NK细胞的功能,以及肿瘤反应性
T细胞。
因此,CI计划有三个主要的科学目标。第一是确定基因组、分子和
TME中免疫功能障碍的细胞途径。CI成员使用临床前模型系统,
CRISPR筛选和人类肿瘤病变,以确定免疫相关的新机制/靶点
失调和优先考虑最终在新的临床试验中测试的免疫治疗抗性/应答的靶点
审判第二,慈善社成员努力制定以科学为基础的战略,
目前的免疫学平台,并确定风险和治疗反应的免疫生物标志物。的
总体目标是将发现进展为创新的临床试验,以测试和验证
提出了抵抗和反应的相关性。第三个目标是开发新的临床适用的免疫
目标是有效控制或根除癌症。CI成员以伙伴关系和跨方案方式工作
来验证免疫疗法抵抗的相关性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Nina Bhardwaj其他文献
Nina Bhardwaj的其他文献
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{{ truncateString('Nina Bhardwaj', 18)}}的其他基金
The Tisch Cancer Institute (TCI) Paul Calabresi K12 Career Development Award for Clinical Oncology
蒂施癌症研究所 (TCI) Paul Calabresi K12 临床肿瘤学职业发展奖
- 批准号:
10434380 - 财政年份:2022
- 资助金额:
$ 2.63万 - 项目类别:
The Tisch Cancer Institute (TCI) Paul Calabresi K12 Career Development Award for Clinical Oncology
蒂施癌症研究所 (TCI) Paul Calabresi K12 临床肿瘤学职业发展奖
- 批准号:
10623252 - 财政年份:2022
- 资助金额:
$ 2.63万 - 项目类别:
Dissecting myeloid cell-mediated resistance to immune checkpoint blockade in bladder cancer
剖析膀胱癌中骨髓细胞介导的免疫检查点阻断抵抗
- 批准号:
10652272 - 财政年份:2020
- 资助金额:
$ 2.63万 - 项目类别:
Dissecting myeloid cell-mediated resistance to immune checkpoint blockade in bladder cancer
剖析膀胱癌中骨髓细胞介导的免疫检查点阻断抵抗
- 批准号:
10380068 - 财政年份:2020
- 资助金额:
$ 2.63万 - 项目类别:
Effect of SARS-CoV-2 on clinical course and NK cells in patients receiving immunotherapy
SARS-CoV-2 对接受免疫治疗的患者临床病程和 NK 细胞的影响
- 批准号:
10203557 - 财政年份:2020
- 资助金额:
$ 2.63万 - 项目类别:
Matrix metalloproteinase-2 modulates inflammation via TLR2
基质金属蛋白酶-2 通过 TLR2 调节炎症
- 批准号:
8777819 - 财政年份:2014
- 资助金额:
$ 2.63万 - 项目类别:
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